当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > Embryonic macrophages of early rat yolk sac: Immunohistochemistry and ultrastructure with reference to endodermal cell layer.

Embryonic macrophages of early rat yolk sac: Immunohistochemistry and ultrastructure with reference to endodermal cell layer.

Abstract：

:Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistochemistry and electron microscopy to investigate early rat yolk sac macrophages using mouse antirat macrophage monoclonal antibodies (mAb) Mar 1 and Mar 3 produced by our laboratory. Mar 3 mAb revealed the first emergence of immature macrophages in the rat yolk sac at fetal day nine coinciding with the beginning of yolk sac haemopoiesis that consisted mainly of erythropoiesis, while Mar 1 mAb detected specifically rat yolk sac macrophages at about the 13th to 14th day of gestation. Immunoreactivity against Mar mAbs was mainly located in the yolk sac endodermal cell layer, which may signify endodermal origin of the yolk sac macrophages. Ultrastructurally mature yolk sac macrophages contained numerous endocytic vesicles or vacuoles, well-developed Golgi saccules and many electron dense granules in their cytoplasm and a number of microvillous projections from the cell surface. After establishment of the circulation between yolk sac and embryo, Mar 3 positive cells were also demonstrated inside fetal undifferentiated mesenchymal tissue at fetal day 12. The study demonstrated the first emergence of immature yolk sac macrophages being among the earliest haemopoietic cells formed in mammalian development. Thus, Mar mAbs managed to detect macrophage differentiation antigens through their development early in the rat yolk sac.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

El-Nefiawy N,Abdel-Hakim K,Yamashita A,Kanayama N

doi

10.1046/j.1440-1711.2002.01109.x

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

441-7

issue

5

eissn

0818-9641

issn

1440-1711

pii

1109

journal_volume

80

pub_type

杂志文章

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Suppressive effects of serum on the LPS-induced production of nitric oxide and TNF-alpha by a macrophage-like cell line, WEHI-3, are dependent on the structure of polysaccharide chains in LPS.

    abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.1999.00807.x

    authors： Ohki K,Amano F,Yamamoto S,Kohashi O

    更新日期：1999-04-01 00:00:00

  • Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses.

    abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2002.01077.x

    authors： Croker BA,Handman E,Hayball JD,Baldwin TM,Voigt V,Cluse LA,Yang FC,Williams DA,Roberts AW

    更新日期：2002-06-01 00:00:00

  • Genetic susceptibility to mycobacterial disease in humans.

    abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1711.2006.01420.x

    authors： Fernando SL,Britton WJ

    更新日期：2006-04-01 00:00:00

  • 'Reverse gear' cellular movement mediated by chemokines.

    abstract：:We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2001.01015.x

    authors： Zlatopolskiy A,Laurence J

    更新日期：2001-08-01 00:00:00

  • Depression of cell-mediated immunity in plasmacytoma-bearing mice.

    abstract：:Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1991.3

    authors： Ruszala-Mallon V,Silva J,Lumanglas AL,Durr FE,Wang BS

    更新日期：1991-02-01 00:00:00

  • Regulation of human Th9 differentiation by type I interferons and IL-21.

    abstract：:Interleukin (IL)-9-producing CD4(+) T cells are a novel subset of T helper (Th) cells that develops independently of the Th1, Th2, Th17 and regulatory T-cell lineages. Similar to the murine model, transforming growth factor (TGF)-beta and IL-4 directed human naive CD4(+) T cells to produce IL-9. Whereas IL-4 suppresse...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.53

    authors： Wong MT,Ye JJ,Alonso MN,Landrigan A,Cheung RK,Engleman E,Utz PJ

    更新日期：2010-08-01 00:00:00

  • The unconventional expression of IL-15 and its role in NK cell homeostasis.

    abstract：:Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effec...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2014.1

    authors： Huntington ND

    更新日期：2014-03-01 00:00:00

  • T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.

    abstract：:CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulat...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2012.71

    authors： Jatzek A,Marie Tejera M,Plisch EH,Fero ML,Suresh M

    更新日期：2013-02-01 00:00:00

  • Characterization of ovine umbilical vein endothelial cells and their expression of cell adhesion molecules: comparative study with human endothelial cells.

    abstract：:This paper reports the isolation and characterization of sheep umbilical vein endothelial cells (ShUVEC) and examines the kinetics of the expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In culture, the cells demonstrate the classical endothelial cell phenot...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1997.4

    authors： Grooby WL,Krishnan R,Russ GR

    更新日期：1997-02-01 00:00:00

  • Novel strategies for controlling Streptococcus pyogenes infection and associated diseases: from potential peptide vaccines to antibody immunotherapy.

    abstract：:Infections caused by group A streptococcus (GAS) represent a public health problem in both developing and developed countries. The current available methods of prevention are either inadequate or ineffective, which is highlighted by the resurgence in invasive GAS infections over the past two decades. The management of...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2009.29

    authors： Pandey M,Sekuloski S,Batzloff MR

    更新日期：2009-07-01 00:00:00

  • 3D computation modelling of the influence of cytokine secretion on Th-cell development suggests that negative selection (inhibition of Th1 cells) is more effective than positive selection by IL-4 for Th2 cell dominance.

    abstract：:Th-cell development has been suggested to include selective mechanisms in which certain cytokines select either Th1 or Th2 cells to proliferate and grow. The selective theory is based on the observation that Th2 cells secrete IL-4, a cytokine that promotes Th2 development, whereas Th1 cells secrete interferon-gamma (I...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/sj.icb.7100023

    authors： Jansson A,Harlen M,Karlsson S,Nilsson P,Cooley M

    更新日期：2007-04-01 00:00:00

  • Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses.

    abstract：:See also: Outstanding Observation by Wirasinha et al., Short Communication by Barnes & Cyster. ...

    journal_title：Immunology and cell biology

    pub_type： 评论,杂志文章

    doi：10.1111/imcb.12027

    authors： Robert R,Mackay CR

    更新日期：2018-04-01 00:00:00

  • Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management.

    abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2015.97

    authors： Chazaud B

    更新日期：2016-02-01 00:00:00

  • TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes.

    abstract：:Interferon regulatory factor (IRF) family members impart cell-type specificity to toll-like receptor (TLR) signalling, and we recently identified a role for IRF6 in TLR2 signalling in epithelial cells. TLR3 has a well-characterized role in wound healing in the skin, and here, we examined TLR3-dependent IRF6 functions ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.77

    authors： Ramnath D,Tunny K,Hohenhaus DM,Pitts CM,Bergot AS,Hogarth PM,Hamilton JA,Kapetanovic R,Sturm RA,Scholz GM,Sweet MJ

    更新日期：2015-10-01 00:00:00

  • Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells.

    abstract：:Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen-specific T cells into a coordinated evolution of effector and memory outcomes. The T cell receptor (TCR) repertoire is highly diverse to account for the highly heterogeneous antigenic world. During...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.16

    authors： Eltahla AA,Rizzetto S,Pirozyan MR,Betz-Stablein BD,Venturi V,Kedzierska K,Lloyd AR,Bull RA,Luciani F

    更新日期：2016-07-01 00:00:00

  • Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation.

    abstract：:Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein-based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.0818-9641.2004.01273.x

    authors： Stewart TJ,Fernando GJ,Frazer IH,Leggatt GR

    更新日期：2004-10-01 00:00:00

  • Deoxyspergualin inhibits cytotoxic T lymphocytes but not NK or LAK cells.

    abstract：:Deoxyspergualin (DOSP) is a new immunosuppressive agent which probably inhibits various functions of monocytes, B cells and T cells. We examined the effects of deoxyspergualin on cellular cytotoxicity, including cytotoxic T lymphocyte (CTL) mediated killer, natural killer (NK) cell and lymphokine activated killer (LAK...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1991.26

    authors： Kerr PG,Atkins RC

    更新日期：1991-06-01 00:00:00

  • Impaired activation of ALS monocytes by exosomes.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease affecting predominantly motor neurons in the spinal cord and motor cortex. Neurodegeneration in ALS is accompanied by a well-characterized neuroinflammatory reaction within the central nervous system and, as described more recentl...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.89

    authors： Zondler L,Feiler MS,Freischmidt A,Ruf WP,Ludolph AC,Danzer KM,Weishaupt JH

    更新日期：2017-02-01 00:00:00

  • Production of a recombinant form of early pregnancy factor that can prolong allogeneic skin graft survival time in rats.

    abstract：:Early pregnancy factor (EPF), an extracellular chaperonin 10 homologue, has immunosuppressive and growth factor properties. In order to carry out more extensive studies on the in vivo characteristics of EPF, a recombinant form of the molecule has been prepared. Recombinant human EPF (rEPF) was expressed in Escherichia...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2000.00951.x

    authors： Morton H,McKay DA,Murphy RM,Somodevilla-Torres MJ,Swanson CE,Cassady AI,Summers KM,Cavanagh AC

    更新日期：2000-12-01 00:00:00

  • Eph/ephrinB signalling is involved in the survival of thymic epithelial cells.

    abstract：:The signals that determine the survival/death of the thymic epithelial cells (TECs) component during embryonic development of the thymus are largely unknown. In this study, we combine different in vivo and in vitro experimental approaches to define the role played by the tyrosine kinase receptors EphB2 and EphB3 and t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2012.59

    authors： García-Ceca J,Alfaro D,Montero-Herradón S,Zapata AG

    更新日期：2013-02-01 00:00:00

  • Exogenous, TAP-independent lysosomal presentation of a respiratory syncytial virus CTL epitope.

    abstract：:Respiratory syncytial virus causes lower respiratory tract infections in infancy and old age, affecting also immunocompromised patients. The viral fusion protein is an important vaccine candidate eliciting antibody and cell-mediated immune responses. CD8(+) cytotoxic T lymphocytes (CTLs) are known to have a role in bo...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2012.43

    authors： Johnstone C,Ramos M,García-Barreno B,López D,Melero JA,Del Val M

    更新日期：2012-11-01 00:00:00

  • Immune response to orally consumed antigens and probiotic bacteria.

    abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2000.00883.x

    authors： Chin J,Turner B,Barchia I,Mullbacher A

    更新日期：2000-02-01 00:00:00

  • Anti-ovine VCAM-1 monoclonal antibodies inhibit adhesion and proliferation between sheep endothelial and mononuclear cells in vitro.

    abstract：:This paper reports the production and characterization of three monoclonal antibodies (mAb) recognizing ovine vascular cell adhesion molecule-1 (VCAM-1). The mAb were raised against sheep umbilical vein endothelial cells (ShUVEC) and flow cytometric analysis demonstrated that one mAb, QE4G9, was cross-reactive with hu...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1997.85

    authors： Grooby WL,Krishnan R,Russ GR

    更新日期：1997-12-01 00:00:00

  • Development of prophylactic and therapeutic vaccines using the ISCOMATRIX adjuvant.

    abstract：:Adjuvants are components that when added to subunit antigen (Ag) vaccines boost their immunogenicity and thus immune efficacy. However, there are few adjuvants that are approved for clinical use resulting in a critical need for the development of safe and effective adjuvants for use in both prophylactic and therapeuti...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2009.21

    authors： Maraskovsky E,Schnurr M,Wilson NS,Robson NC,Boyle J,Drane D

    更新日期：2009-07-01 00:00:00

  • Regulation of mucosal mast cell activation by short interfering RNAs targeting syntaxin4.

    abstract：:Mucosal mast cells (MMCs) have an important role in allergic inflammation, and effective antagonists are required for their regulation. To discover a possible mechanism of controlling the activation of MMCs, we investigated the expression and function of syntaxin4, one of the soluble membrane N-ethylmaleimide-sensitiv...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2011.41

    authors： Liu S,Nugroho AE,Shudou M,Maeyama K

    更新日期：2012-03-01 00:00:00

  • The human non-lineage antigen CD46 (HuLy-m5) and primate retroviral gp70 molecules share protein-defined antigenic determinants.

    abstract：:The CD46 lymphocyte surface antigen of man (until recently called HuLy-m5), and defined by the E4.3 monoclonal antibody (MoAb), shares cross-reactive antigenic epitopes with the envelope gp70 glycoproteins of gibbon ape leukaemia virus (GaLV) and Mason Pfizer monkey virus (MPMV) primate retroviruses. It is now shown t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1989.42

    authors： Purcell DF,Deacon NJ,McKenzie IF

    更新日期：1989-10-01 00:00:00

  • Macrophage inflammatory protein-2 and vascular endothelial growth factor regulate corneal neovascularization induced by infection with Pseudomonas aeruginosa in mice.

    abstract：:Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2002.01094.x

    authors： Xue ML,Thakur A,Willcox M

    更新日期：2002-08-01 00:00:00

  • Restoration of hepatic mast cells and expression of a different mast cell protease phenotype in regenerating rat liver after 70%-hepatectomy.

    abstract：:Mast cells (MC) can undergo significant changes in number and phenotype; these alterations result in the differential expression of growth factors and cytokines. Kit ligand (KL; stem cell factor) is produced by mesenchymal cells, and in the liver by biliary epithelial cells. Recent studies suggest that KL, and its rec...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2005.01368.x

    authors： Zweifel M,Breu K,Matozan K,Renner E,Welle M,Schaffner T,Clavien PA

    更新日期：2005-12-01 00:00:00

  • Life and death in the granuloma: immunopathology of tuberculosis.

    abstract：:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/sj.icb.7100027

    authors： Saunders BM,Britton WJ

    更新日期：2007-02-01 00:00:00

  • Antibody blockade of Thy-1 (CD90) impairs mouse cytotoxic T lymphocyte induction by anti-CD3 monoclonal antibody.

    abstract：:Thy-1 (CD90) expressed by mouse T cells is known to have signal transducing properties, but the ability of Thy-1 to enhance cytotoxic T lymphocyte (CTL) development is not well understood. Here we show that stimulation of mouse T cells with monoclonal antibodies (mAb) to CD3, CD28 and Thy-1 (clone G7), which were coim...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2005.01342.x

    authors： Haeryfar SM,Conrad DM,Musgrave B,Hoskin DW

    更新日期：2005-08-01 00:00:00