Deoxyspergualin inhibits cytotoxic T lymphocytes but not NK or LAK cells.

abstract：:Vaccination has been important in controlling a wide variety of viral and bacterial infections of man and animals. Vaccines to herpesvirus infection of cattle are no exception. The present review describes the different types of conventional vaccines that have been used to date and furthermore describes the novel appr...

journal_title：Immunology and cell biology

authors： van Drunen Littel-van den Hurk S,Tikoo SK,Liang X,Babiuk LA

更新日期：1993-10-01 00:00:00

abstract：:The role of plasmacytoid dendritic cells (pDC) in anti-HIV immunity is mostly represented by the production of type I IFN in response to HIV infection in vitro and in vivo. This production is decreased in HIV-1 infected patients at the time of primary infection and during chronic disease in association with progressio...

journal_title：Immunology and cell biology

authors： Müller-Trutwin M,Hosmalin A

更新日期：2005-10-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...

journal_title：Immunology and cell biology

authors： Abdel-Nour M,Tsalikis J,Kleinman D,Girardin SE

更新日期：2014-04-01 00:00:00

abstract：:Activins and inhibins are members of the transforming growth factor-β superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation...

journal_title：Immunology and cell biology

authors： Aleman-Muench GR,Soldevila G

更新日期：2012-02-01 00:00:00

abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

journal_title：Immunology and cell biology

authors： Sanchez D,Ganfornina MD,Bastiani MJ

更新日期：1995-12-01 00:00:00

abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

journal_title：Immunology and cell biology

authors： Wilson NS,Villadangos JA

更新日期：2004-02-01 00:00:00

abstract：:Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macr...

journal_title：Immunology and cell biology

authors： Dubey A,Izakelian L,Ayaub EA,Ho L,Stephenson K,Wong S,Kwofie K,Austin RC,Botelho F,Ask K,Richards CD

更新日期：2018-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease affecting predominantly motor neurons in the spinal cord and motor cortex. Neurodegeneration in ALS is accompanied by a well-characterized neuroinflammatory reaction within the central nervous system and, as described more recentl...

journal_title：Immunology and cell biology

authors： Zondler L,Feiler MS,Freischmidt A,Ruf WP,Ludolph AC,Danzer KM,Weishaupt JH

更新日期：2017-02-01 00:00:00

abstract：:Latex beads, 250 and 610 nm in diameter, and parapox virus isolated from ecthyma in sheep, were injected into intestinal loops containing either jejunal or ileal Peyer's patches (PP) of 3-4 week old calves. Uptake of latex and parapox virus was restricted to the ileal PP, 30-60 min after injection. The latex beads see...

journal_title：Immunology and cell biology

authors： Landsverk T

更新日期：1988-08-01 00:00:00

abstract：:The present study demonstrates that SRBC can be opsonized with untreated human serum such that lysis by active complement components is minimal but sufficient opsonization occurs to permit high rates of complement-mediated phagocytosis. Phagocytosis of SRBC opsonized with 2% whole human serum by human monocyte-derived...

journal_title：Immunology and cell biology

authors： Chan HT,Kedzierska K,O'Mullane J,Crowe SM,Jaworowski A

更新日期：2001-10-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) and its receptor c-Met signaling have been implicated in regulating various types of cells including epithelial cells. We have previously reported that c-Met is expressed by thymic epithelial cells (TECs), and that in vivo administration of hybrid cytokines containing IL-7 and the beta- ...

journal_title：Immunology and cell biology

authors： Su M,Hu R,Song Y,Liu Y,Lai L

更新日期：2018-02-01 00:00:00

abstract：:A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal di...

journal_title：Immunology and cell biology

authors： Ho ES,O'Neill HC

更新日期：1995-06-01 00:00:00

abstract：:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...

journal_title：Immunology and cell biology

authors： Saunders BM,Britton WJ

更新日期：2007-02-01 00:00:00

abstract：:Cancer immunosurveillance representing, till recently, the explanatory framework relating cancer and the immune system, does not convincingly explain tumor escape. At the beginning of the decade, a new theory emerged, namely the immunoediting theory, and it comprehensively defines the role of the immune system in carc...

journal_title：Immunology and cell biology

authors： Germenis AE,Karanikas V

更新日期：2007-01-01 00:00:00

abstract：:Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...

journal_title：Immunology and cell biology

authors： Xue ML,Thakur A,Willcox M

更新日期：2002-08-01 00:00:00

abstract：:The discovery of functional long noncoding RNAs (lncRNAs) coupled with the ever-increasing accessibility of genomic and transcriptomic technology has led to an explosion of functional and mechanistic investigation and discovery into what was once dismissed as junk DNA. Over the past decade, a significant number of lnc...

journal_title：Immunology and cell biology

authors： Yu AD,Wang Z,Morris KV

更新日期：2015-03-01 00:00:00

abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

journal_title：Immunology and cell biology

authors： Ohki K,Amano F,Yamamoto S,Kohashi O

更新日期：1999-04-01 00:00:00

abstract：:In order to analyse Th2-type immune responses in sheep by the assay of interleukin (IL)-5 in biological fluids, the ovine IL-5 gene was cloned and expressed in Spodoptera frugiperda Sf9 insect cells using the baculovirus expression vector system. The recombinant product was purified as BAC-OV-IL-5 from the supernatant...

journal_title：Immunology and cell biology

authors： Bosward K,Emery DL,McWaters PW,Husband AJ,Bendixsen T

更新日期：1999-08-01 00:00:00

abstract：:Th-cell differentiation is highly influenced by the local cytokine environment. Although cytokines such as IL-12 and IL-4 are known to polarize the Th-cell response towards Th1 or Th2, respectively, it is not known whether these cytokines instruct the developmental fate of uncommitted Th cells or select cells that hav...

journal_title：Immunology and cell biology

authors： Jansson A,Fagerlind M,Karlsson D,Nilsson P,Cooley M

更新日期：2006-04-01 00:00:00

abstract：:Chronic obstructive pulmonary disease is a highly prevalent, complex disease, usually caused by cigarette smoke. It causes serious morbidity and mortality and costs the global community billions of dollars per year. While chronic inflammation, extracellular matrix destruction and increased airway epithelial cell apopt...

journal_title：Immunology and cell biology

authors： Hodge S,Hodge G,Scicchitano R,Reynolds PN,Holmes M

更新日期：2003-08-01 00:00:00

abstract：:The mechanisms involved in the inhibition of growth of a human B lymphoma cell line, B104, by anti-MHC class II antibodies (Ab) were compared with those in anti-IgM Ab-induced B104 growth inhibition. Two anti-MHC class II Ab, L227 and 2.06, inhibited the growth of B104 cells, although 2.06, but not L227, needed to be ...

journal_title：Immunology and cell biology

authors： Higaki Y,Hata D,Kanazashi S,Horiguchi Y,Yamaoka K,Ohshima Y,Kim KM,Heike T,Mayumi M

更新日期：1994-06-01 00:00:00

abstract：:Listeria monocytogenes is the causative agent of infections like sepsis and meningitis, especially in immunocompromised hosts. Human macrophages are able to phagocytose and digest L. monocytogenes but IL-4 prevents human macrophages from killing the bacteria, the mechanisms of which are unknown. In the present study, ...

journal_title：Immunology and cell biology

authors： Neumann K,Eppler E,Filgueira L,Groscurth P,Gasal E,Schaffner A,Schoedon G,Schneemann M

更新日期：2003-12-01 00:00:00

abstract：:The germinal centre reaction (GCR) is a fundamental component of the immune response to T-dependent antigens, during which the immunoglobulin (Ig) genes of B cells experience somatic hypermutation and selection. A maximum-likelihood method on DNA sequence data from 16 individual germinal centres was used to infer that...

journal_title：Immunology and cell biology

authors： Radmacher MD,Kelsoe G,Kepler TB

更新日期：1998-08-01 00:00:00

abstract：:A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

journal_title：Immunology and cell biology

authors： Aalberse RC

更新日期：1996-04-01 00:00:00

abstract：:Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosphatase 1 (SHP-1, Pt...

journal_title：Immunology and cell biology

authors： Watson HA,Dolton G,Ohme J,Ladell K,Vigar M,Wehenkel S,Hindley J,Mohammed RN,Miners K,Luckwell RA,Price DA,Matthews RJ,Ager A

更新日期：2016-09-01 00:00:00

abstract：:Inappropriate activation of p34cdc2 kinase has been shown to occur during apoptosis induced by cytotoxic T-cell derived perforin and fragmentin. We analysed the effect of two inhibitors of p34cdc2 kinase on alloreactive Tc-cell-mediated lysis and DNA fragmentation of P815 and L1210 target cells. Olomoucine, a specific...

journal_title：Immunology and cell biology

authors： Waring P,Müllbacher A

更新日期：2001-06-01 00:00:00

abstract：:Tumour cell heterogeneity is probably a principal cause of treatment failure and represents a formidable barrier for effective antibody-targeted chemotherapy. Idarubicin (Ida), a more potent and less cardiotoxic analogue of daunomycin, has been demonstrated to specifically target and eradicate homogeneous, cloned, mur...

journal_title：Immunology and cell biology

authors： Smyth MJ,Foster HM,Andrew SM,Teh JG,Krauer K,McKenzie IF,Pietersz GA

更新日期：1993-06-01 00:00:00

abstract：:Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...

journal_title：Immunology and cell biology

authors： Tarlinton D

更新日期：2020-07-01 00:00:00

abstract：:The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...

journal_title：Immunology and cell biology

authors： Chandrashekar R,Rao UR,Subrahmanyam D

更新日期：1990-02-01 00:00:00

abstract：:Technetium-99 m (99mTc)-labelled conjugates of an anti-fibrin monoclonal antibody, DD-3B6/22, have been assessed for their detection of vascular thrombi in a rabbit model. DD-3B6/22 binds to a D-dimer epitope present on cross-linked fibrin but absent from the fibrin monomer or fibrinogen. Injection of a 99mTc-labelled...

journal_title：Immunology and cell biology

authors： Lee FT,Milner LJ,Boniface GR,Bautovich GJ,Weedon AR,Bundesen PG,Rylatt DB,Walker KZ

更新日期：1992-06-01 00:00:00