Quantifying complement-mediated phagocytosis by human monocyte-derived macrophages.

abstract：:Tamm-Horsfall protein (THP) binds strongly to complement 1q (C1q), a key component of the classical complement pathway. The goals of this study were to determine whether THP altered the activation of the classical complement pathway and whether the carbohydrate portion of THP was involved in this glycoprotein's bindin...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2006-08-01 00:00:00

abstract：:Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...

journal_title：Immunology and cell biology

authors： Iba Y,Kurosawa Y

更新日期：1997-04-01 00:00:00

abstract：:Th-cell differentiation is highly influenced by the local cytokine environment. Although cytokines such as IL-12 and IL-4 are known to polarize the Th-cell response towards Th1 or Th2, respectively, it is not known whether these cytokines instruct the developmental fate of uncommitted Th cells or select cells that hav...

journal_title：Immunology and cell biology

authors： Jansson A,Fagerlind M,Karlsson D,Nilsson P,Cooley M

更新日期：2006-04-01 00:00:00

abstract：:During an allergic inflammatory response in the airway, if a failure of the epithelial cell barrier occurs before the systemic immune response is triggered by allergens, more allergens can invade. Using a rat model of asthma, we previously found that mucosal mast cells, which localise to the epithelial layer of the ai...

journal_title：Immunology and cell biology

authors： Liu S,Shudou M,Maeyama K

更新日期：2011-02-01 00:00:00

abstract：:Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the m...

journal_title：Immunology and cell biology

authors： Miyara M,Sakaguchi S

更新日期：2011-03-01 00:00:00

abstract：:Cancer immunosurveillance representing, till recently, the explanatory framework relating cancer and the immune system, does not convincingly explain tumor escape. At the beginning of the decade, a new theory emerged, namely the immunoediting theory, and it comprehensively defines the role of the immune system in carc...

journal_title：Immunology and cell biology

authors： Germenis AE,Karanikas V

更新日期：2007-01-01 00:00:00

abstract：:The trace element zinc is essential for the survival and function of all cells. Zinc deficiency, whether nutritional or genetic, is fatal if left untreated. The effects of zinc deficiency are particularly obvious in the skin, seen as an erythematous rash, scaly plaques, and ulcers. Electron microscopy reveals degenera...

journal_title：Immunology and cell biology

authors： Wilson D,Varigos G,Ackland ML

更新日期：2006-02-01 00:00:00

abstract：:Interferon regulatory factor (IRF) family members impart cell-type specificity to toll-like receptor (TLR) signalling, and we recently identified a role for IRF6 in TLR2 signalling in epithelial cells. TLR3 has a well-characterized role in wound healing in the skin, and here, we examined TLR3-dependent IRF6 functions ...

journal_title：Immunology and cell biology

authors： Ramnath D,Tunny K,Hohenhaus DM,Pitts CM,Bergot AS,Hogarth PM,Hamilton JA,Kapetanovic R,Sturm RA,Scholz GM,Sweet MJ

更新日期：2015-10-01 00:00:00

abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

journal_title：Immunology and cell biology

authors： Lipoldová M,Holán V

更新日期：1991-12-01 00:00:00

abstract：:Mucosal addressin cell adhesion molecule (MAdCAM-1) is a key player in mediating the infiltration of leucocytes into chronically inflamed tissues. Five anti-MAdCAM-1 monoclonal antibodies (mAb), designated 17F5, 201F7, 314G8, 377D10 and 355G8, were generated by fusion of P3 x 63Ag8.653 myeloma cells with spleen cells ...

journal_title：Immunology and cell biology

authors： Leung E,Lehnert KB,Kanwar JR,Yang Y,Mon Y,McNeil HP,Krissansen GW

更新日期：2004-08-01 00:00:00

abstract：:Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effec...

journal_title：Immunology and cell biology

authors： Huntington ND

更新日期：2014-03-01 00:00:00

abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

journal_title：Immunology and cell biology

authors： Fernando SL,Britton WJ

更新日期：2006-04-01 00:00:00

abstract：:Non-toxic agents that target intracellular signalling pathways in apoptosis may have potential therapeutic use in many diseases. One such agent is the transition metal Zn, a dietary cytoprotectant and anti-oxidant, which stimulates cell proliferation and suppresses apoptosis. Zn is maintained in discrete subcellular p...

journal_title：Immunology and cell biology

authors： Chai F,Truong-Tran AQ,Ho LH,Zalewski PD

更新日期：1999-06-01 00:00:00

abstract：:The Australian populations of rainbow trout (Onchorhynchus mykiss) and Atlantic salmon (Salmo salar) were found to have similar immunological responses to local strains of Vibrio anguillarum as those reported for the more genetically diverse populations of these fish and strains of V. anguillarum found in the Northern...

journal_title：Immunology and cell biology

authors： Munday BL,Carson J,Whittington R,Alexander J

更新日期：1992-12-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is typically associated with extensive and progressive fibrosis, and is fatal and has limited treatment options. Characteristically IPF patients display large lymphocyte aggregates composed of CD3+ T cells and CD20+ B ...

journal_title：Immunology and cell biology

authors： Hoyne GF,Elliott H,Mutsaers SE,Prêle CM

更新日期：2017-08-01 00:00:00

abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

journal_title：Immunology and cell biology

authors： Wilson NS,Villadangos JA

更新日期：2004-02-01 00:00:00

abstract：:By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

journal_title：Immunology and cell biology

authors： Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

更新日期：1993-08-01 00:00:00

abstract：:Two related folate antagonists aminopterin (AMN) and methotrexate (MTX) were used to produce drug-antibody conjugates and their tumouricidal effects compared in vitro and in vivo. Active ester derivatives were produced with the use of N-hydroxysuccinimide (NHS) and covalently coupled to monoclonal antibodies (MoAb) re...

journal_title：Immunology and cell biology

authors： Kanellos J,Pietersz GA,Cunningham Z,McKenzie IF

更新日期：1987-12-01 00:00:00

abstract：:During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...

journal_title：Immunology and cell biology

authors： Balboa L,Romero MM,Yokobori N,Schierloh P,Geffner L,Basile JI,Musella RM,Abbate E,de la Barrera S,Sasiain MC,Alemán M

更新日期：2010-10-01 00:00:00

abstract：:Active Brugia pahangi microfilariae (Mf) were injected into naive male BALB/c mice intraperitoneally. Microfilaraemia was studied for 28 days; and Mf circulated in blood in optimum numbers from 3 to 14 days. Anti-Mf response was assessed by the rate of disappearance of Mf from blood as well as their absence from visce...

journal_title：Immunology and cell biology

authors： Rajasekariah GR,Puri PM,Chandrashekar R,Subrahmanyam D

更新日期：1988-10-01 00:00:00

abstract：:Concanavalin A (Con A)-induced hepatitis is thought to be a T-cell-mediated disease with active destruction of liver cells. Interleukin (IL)-17 is a cytokine produced principally by CD4(+) T cells. However, whether IL-17/IL-17 receptor (IL-17/IL-17R)-mediated responses are involved in T-cell-mediated Con A-induced liv...

journal_title：Immunology and cell biology

authors： Yan S,Wang L,Liu N,Wang Y,Chu Y

更新日期：2012-04-01 00:00:00

abstract：:A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal di...

journal_title：Immunology and cell biology

authors： Ho ES,O'Neill HC

更新日期：1995-06-01 00:00:00

abstract：:PVG rats are resistant to actively induced experimental autoimmune encephalomyelitis (EAE) and this appears to be directly related to high and sustained systemic levels of reactive nitrogen intermediates(RNI) following sensitization for EAE when compared to the highly susceptible Lewis rat. An apparent cellular basis ...

journal_title：Immunology and cell biology

authors： Staykova MA,Cowden W,Willenborg DO

更新日期：2002-04-01 00:00:00

abstract：:The cellular effects of biodiesel emissions particulate matter (BDEP) and petroleum diesel emissions particulate matter (PDEP) were compared using a human airway cell line, A549. At concentrations of 25 microg/ml, diesel particulate matter induced the formation of multinucleate cells. In cells treated with a mixture o...

journal_title：Immunology and cell biology

authors： Ackland ML,Zou L,Freestone D,van de Waasenburg S,Michalczyk AA

更新日期：2007-11-01 00:00:00

abstract：:The signals that determine the survival/death of the thymic epithelial cells (TECs) component during embryonic development of the thymus are largely unknown. In this study, we combine different in vivo and in vitro experimental approaches to define the role played by the tyrosine kinase receptors EphB2 and EphB3 and t...

journal_title：Immunology and cell biology

authors： García-Ceca J,Alfaro D,Montero-Herradón S,Zapata AG

更新日期：2013-02-01 00:00:00

abstract：:In the developing forebrain, mounting evidence suggests that neural stem cell proliferation and differentiation is regulated by growth factors. In vitro in the presence of serum, stem cell proliferation is predominantly mediated by fibroblast growth factor-2 (FGF-2) whereas neuronal differentiation can be triggered by...

journal_title：Immunology and cell biology

authors： Bartlett PF,Brooker GJ,Faux CH,Dutton R,Murphy M,Turnley A,Kilpatrick TJ

更新日期：1998-10-01 00:00:00

abstract：:Interleukin (IL)-9-producing CD4(+) T cells are a novel subset of T helper (Th) cells that develops independently of the Th1, Th2, Th17 and regulatory T-cell lineages. Similar to the murine model, transforming growth factor (TGF)-beta and IL-4 directed human naive CD4(+) T cells to produce IL-9. Whereas IL-4 suppresse...

journal_title：Immunology and cell biology

authors： Wong MT,Ye JJ,Alonso MN,Landrigan A,Cheung RK,Engleman E,Utz PJ

更新日期：2010-08-01 00:00:00

abstract：:Lymphocytes exchanged rapidly and extensively between mutually tolerant, allogeneic rats following surgical parabiosis. Tolerated allogeneic cells persisted for an extended period in parabiotic partners after separation. A rapid exchange of cells was also observed between parabiosed syngeneic pairs of normal and allog...

journal_title：Immunology and cell biology

authors： McCullagh P

更新日期：1987-06-01 00:00:00

abstract：:Infection of mice with the flaviviruses West Nile virus (WNV) and Murray Valley encephalitis (MVE) induces cytolytic T-cell responses which are highly cross-reactive on target cells infected with heterologous flaviviruses. Of C57BL/6 mice infected with low doses (10(2)-10(6) PFU) of either virus, 30-40% develop enceph...

journal_title：Immunology and cell biology

authors： Wang Y,Lobigs M,Lee E,Müllbacher A

更新日期：2004-04-01 00:00:00

abstract：:Adjuvants are components that when added to subunit antigen (Ag) vaccines boost their immunogenicity and thus immune efficacy. However, there are few adjuvants that are approved for clinical use resulting in a critical need for the development of safe and effective adjuvants for use in both prophylactic and therapeuti...

journal_title：Immunology and cell biology

authors： Maraskovsky E,Schnurr M,Wilson NS,Robson NC,Boyle J,Drane D

更新日期：2009-07-01 00:00:00