Abstract:
:Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effector role in the clearance of virus-infected and transformed cells. NK cells are dependent on the pleiotropic cytokine interleukin (IL)-15 for their development, differentiation and optimal function. Here I review the regulation of IL-15 in vivo, its role in driving NK cell differentiation and discuss the function of NK cell diversification with regard to innate immunity.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Huntington NDdoi
10.1038/icb.2014.1subject
Has Abstractpub_date
2014-03-01 00:00:00pages
210-3issue
3eissn
0818-9641issn
1440-1711pii
icb20141journal_volume
92pub_type
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