Abstract：
:The pathogenesis of autoimmune disease remains an enigma. Here, the condition is analysed from an evolutionary standpoint, and the thesis developed that viruses, in particular retroviruses, are important to our evolution, and that their inappropriate re-expression by repetitive (? ischaemic) cell damage in individuals of appropriate major histocompatibility type, leads to autoimmune disease. Such a view requires a slight adjustment to traditional ways of seeing Darwinian evolution, but one which makes real sense of the MHC-restricted nature of the adaptive immune response.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Boyd GWdoi
10.1038/icb.1997.78subject
Has Abstractpub_date
1997-10-01 00:00:00pages
503-7issue
5eissn
0818-9641issn
1440-1711journal_volume
75pub_type
杂志文章,评审abstract：:We recently demonstrated that 17beta-estradiol (E2) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect of E2 on leishmanicidal activity and cytokine production by bone marrow-derived macrophages (BMDMs) f...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2008.39
更新日期：2008-08-01 00:00:00
abstract：:Vaccination has been important in controlling a wide variety of viral and bacterial infections of man and animals. Vaccines to herpesvirus infection of cattle are no exception. The present review describes the different types of conventional vaccines that have been used to date and furthermore describes the novel appr...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1993.47
更新日期：1993-10-01 00:00:00
abstract：:Regulatory mechanisms in mucosal secretions and tissues recognize antigens and attenuate pro-inflammatory cytokine responses. Here, we asked whether human beta-defensin 3 (HBD3) serves as an upstream suppressor of cytokine signaling that binds and attenuates pro-inflammatory cytokine responses to recombinant hemagglut...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2008.56
更新日期：2008-11-01 00:00:00
abstract：:The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellul...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12313
更新日期：2020-03-01 00:00:00
abstract：:Ficolins are important and widely distributed pattern recognition molecules that can induce lectin complement pathway activation and initiate the innate immune response. Although ficolins can bind lipopolysaccharide (LPS) in vitro, the sources, dynamic changes and roles of local ficolins in LPS-induced pulmonary infla...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12344
更新日期：2020-08-01 00:00:00
abstract：:Today's generally accepted view of the self-nonself discrimination was voiced by Miller(1) in 2004 in a thought-provoking essay. In spite of its popularity, this position has its limitations, which are analyzed here with a view toward establishing an interactive discussion that hopefully will culminate in agreed upon ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2008.96
更新日期：2009-02-01 00:00:00
abstract：:Variola virus, the causative agent of smallpox, is a member of the poxvirus family and one of the most virulent human pathogens known. Although smallpox was eradicated almost 30 years ago, it is not understood why the mortality rates associated with the disease were high, why some patients recovered, and what constitu...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/sj.icb.7100033
更新日期：2007-02-01 00:00:00
abstract：:A clone of cells secreting an antibody to an epidermal antigen was generated from a patient with a blistering skin lesion. Although produced by fusion of human lymphocytes to a HAT-sensitive myeloma, this clone of cells did not have characteristics of a hybridoma. A true hybridoma was produced by fusion of this clone ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1988.30
更新日期：1988-01-01 00:00:00
abstract：:The cytokine Tumor Necrosis Factor Superfamily member 14, TNFSF14 (or LIGHT), is a controversial player in numerous diseases. We investigated the role of endogenously expressed TNFSF14 in diet-induced obesity in vivo. Firstly, we studied the effects of Tnfsf14 ablation on the development of obesity, glucose intoleranc...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.1002
更新日期：2018-01-01 00:00:00
abstract：:Adult Nematospiroides dubius excretory-secretory (ES) products were collected from worms cultured in vitro, radiolabelled and separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE). The components were characterized and assessed for molecular weight (MW) after autoradiography and gel staining, for a...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1989.16
更新日期：1989-04-01 00:00:00
abstract：:Granzyme B (GrB) plays a well-established intracellular role in cytotoxic lymphocyte (CL)-mediated killing of abnormal cells; however, emerging evidence suggests that it participates in extracellular matrix remodeling and target cell destruction through anoikis. As these processes require the release of GrB from the C...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2008.98
更新日期：2009-03-01 00:00:00
abstract：:Mammalian barrier surfaces, including the skin, lung and intestine, are constantly exposed to environmental stimuli, including beneficial and pathogenic microbes, dietary substances and non-organic materials. At these anatomical sites it is essential to maintain barrier integrity to promote tissue homeostasis and prev...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2013.2
更新日期：2013-03-01 00:00:00
abstract：:Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase-deficient conditions. This alternative ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2016.120
更新日期：2017-02-01 00:00:00
abstract：:Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1991.3
更新日期：1991-02-01 00:00:00
abstract：:Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-reg...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2011.101
更新日期：2012-01-01 00:00:00
abstract：:CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulat...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2012.71
更新日期：2013-02-01 00:00:00
abstract：:Respiratory syncytial virus causes lower respiratory tract infections in infancy and old age, affecting also immunocompromised patients. The viral fusion protein is an important vaccine candidate eliciting antibody and cell-mediated immune responses. CD8(+) cytotoxic T lymphocytes (CTLs) are known to have a role in bo...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2012.43
更新日期：2012-11-01 00:00:00
abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2002.01077.x
更新日期：2002-06-01 00:00:00
abstract：:Regulating the strength and class of an immune response requires lymphocytes to act as complex signal integrating "machines", taking information from multiple sources while making decisions that affect the final outcome. Describing and understanding the decision-making behaviour of lymphocytes within the context of th...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/sj.icb.7100061
更新日期：2007-06-01 00:00:00
abstract：:In order to analyse Th2-type immune responses in sheep by the assay of interleukin (IL)-5 in biological fluids, the ovine IL-5 gene was cloned and expressed in Spodoptera frugiperda Sf9 insect cells using the baculovirus expression vector system. The recombinant product was purified as BAC-OV-IL-5 from the supernatant...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1999.00831.x
更新日期：1999-08-01 00:00:00
abstract：:As host immunological defenses are impaired during HIV infection, it is difficult to elicit good responses when attempting to develop therapeutic vaccines against HIV. To try to solve this situation, adjuvants, particularly cytokines, are currently under evaluation. Owing to the fact that adenosine deaminase (ADA) is ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2009.53
更新日期：2009-11-01 00:00:00
abstract：:The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...
journal_title：Immunology and cell biology
pub_type： 社论
doi：10.1111/imcb.12348
更新日期：2020-07-01 00:00:00
abstract：:Endothelial cell (EC)-neutrophil (PMN) interactions are crucial in the resolution of bacterial infections. Prokaryotic RNA (pRNA) has been reported as a pathogen-associated molecular pattern that is released from bacteria upon death and is able to activate PMN. In this work, we studied the effects of pRNA on EC and in...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12282
更新日期：2019-10-01 00:00:00
abstract：:The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cance...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1111/imcb.12377
更新日期：2020-07-16 00:00:00
abstract：:The utility of T-cell receptor (TCR) transgenic mice in medical research has been considerable, with applications ranging from basic biology all the way to translational and clinical investigations. Crossing of TCR transgenic mice with either recombination-activating gene (RAG)-1 or RAG-2 knockouts is frequently used ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12033
更新日期：2018-07-01 00:00:00
abstract：:It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The ev...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1996.50
更新日期：1996-06-01 00:00:00
abstract：:Almost all vaccinations today are delivered through parenteral routes. Mucosal vaccination offers several benefits over parenteral routes of vaccination, including ease of administration, the possibility of self-administration, elimination of the chance of injection with infected needles, and induction of mucosal as w...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1711.2004.01288.x
更新日期：2004-12-01 00:00:00
abstract：:The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2002.01125.x
更新日期：2002-12-01 00:00:00
abstract：:Epstein-Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong persistence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: latency in B lymphocytes and replication i...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1995.79
更新日期：1995-12-01 00:00:00
abstract：:This paper reports the production and characterization of three monoclonal antibodies (mAb) recognizing ovine vascular cell adhesion molecule-1 (VCAM-1). The mAb were raised against sheep umbilical vein endothelial cells (ShUVEC) and flow cytometric analysis demonstrated that one mAb, QE4G9, was cross-reactive with hu...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1997.85
更新日期：1997-12-01 00:00:00
