Abstract:
:Adult Nematospiroides dubius excretory-secretory (ES) products were collected from worms cultured in vitro, radiolabelled and separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE). The components were characterized and assessed for molecular weight (MW) after autoradiography and gel staining, for antigenicity in immunoblots, for sensitivity to protease enzymes, and for carbohydrate content. ES contained at least 18 denatured components from MW less than 20,000 to greater than 200,000. At least one of the surface proteins of adults was found with the ES antigens recovered when adults were cultured in vitro. Molecules with MW 200,000, 78,000 and 60,000 were glycoproteins and reacted with immune mouse serum in Western blots. The dominant ES, MW 60,000 component stained with periodic acid-Schiff (PAS), bound lectins with affinity for D-mannose, and was resistant to peptic and tryptic but not V8 protease digestion.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Monroy FG,Adams JH,East IJ,Dobson Cdoi
10.1038/icb.1989.16subject
Has Abstractpub_date
1989-04-01 00:00:00pages
115-20eissn
0818-9641issn
1440-1711journal_volume
67 ( Pt 2)pub_type
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