CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.

abstract：:Acute rejection is the major determinant for the long-term survival of donor liver after liver transplantation (LT). The aim of this study was to examine the therapeutic potential of interleukin (IL)-10-FasL-overexpressing immature dendritic cells (imDCs) to induce local immunosuppression in liver grafts. imDCs derive...

journal_title：Immunology and cell biology

authors： Chen L,Zhang L,Zhu Z,He W,Gao L,Zhang W,Liu J,Huang A

更新日期：2019-09-01 00:00:00

abstract：:Mucosal mast cells (MMCs) have an important role in allergic inflammation, and effective antagonists are required for their regulation. To discover a possible mechanism of controlling the activation of MMCs, we investigated the expression and function of syntaxin4, one of the soluble membrane N-ethylmaleimide-sensitiv...

journal_title：Immunology and cell biology

authors： Liu S,Nugroho AE,Shudou M,Maeyama K

更新日期：2012-03-01 00:00:00

abstract：:Activins and inhibins are members of the transforming growth factor-β superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation...

journal_title：Immunology and cell biology

authors： Aleman-Muench GR,Soldevila G

更新日期：2012-02-01 00:00:00

abstract：:Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as w...

journal_title：Immunology and cell biology

authors： Patras KA,Coady A,Olson J,Ali SR,RamachandraRao SP,Kumar S,Varki A,Nizet V

更新日期：2017-11-01 00:00:00

abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...

journal_title：Immunology and cell biology

authors： Croker BA,Handman E,Hayball JD,Baldwin TM,Voigt V,Cluse LA,Yang FC,Williams DA,Roberts AW

更新日期：2002-06-01 00:00:00

abstract：:By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

journal_title：Immunology and cell biology

authors： Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

更新日期：1993-08-01 00:00:00

abstract：:This paper reports the production and characterization of three monoclonal antibodies (mAb) recognizing ovine vascular cell adhesion molecule-1 (VCAM-1). The mAb were raised against sheep umbilical vein endothelial cells (ShUVEC) and flow cytometric analysis demonstrated that one mAb, QE4G9, was cross-reactive with hu...

journal_title：Immunology and cell biology

authors： Grooby WL,Krishnan R,Russ GR

更新日期：1997-12-01 00:00:00

abstract：:It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The ev...

journal_title：Immunology and cell biology

authors： Anderson RW

更新日期：1996-06-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE) is a membrane-bound metalloprotease and disintegrin. It is produced by a number of host cells and is known to shed and release cell-bound cytokines, particularly members of the TNF family. No investigations into the regulation of this enzyme by autoanti...

journal_title：Immunology and cell biology

authors： Lisi S,Sisto M

更新日期：2010-03-01 00:00:00

abstract：:Activin A, a member of the transforming growth factor-β superfamily, is a critical early mediator of acute inflammation. Activin A release coincides with the release of tumour necrosis factor-α (TNF-α) in models of lipopolysaccharide (LPS)-induced inflammation. The source of circulating activin A during acute inflamma...

journal_title：Immunology and cell biology

authors： Chen Y,Wu H,Winnall WR,Loveland KL,Makanji Y,Phillips DJ,Smith JA,Hedger MP

更新日期：2011-11-01 00:00:00

abstract：:Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. A phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) mediates cluster formation of the host fungal receptors and enhances the phagocytosis and clearance of pathogenic fungi. Howe...

journal_title：Immunology and cell biology

authors： Zhao G,Hu M,Li C,Lee J,Yuan K,Zhu G,Che C

更新日期：2018-04-01 00:00:00

abstract：:A derivative of ammonia caramel colour (AC) is known to induce a selective lymphopenia in rats. Accordingly, the haematological effects were studied in mice of oral administration in drinking water of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), the component of AC responsible for lymphopenia. Initially five groups...

journal_title：Immunology and cell biology

authors： Iscaro A,Mackay IR,O'Brien C

更新日期：1988-10-01 00:00:00

abstract：:Plasma cells play a pivotal role in the immune system and are responsible for the synthesis and release of immunoglobulins. Numerous in vitro culture experiments on the yolk sac demonstrated the generation of mature cells of the myeloid and lymphoid lineages under appropriate culture conditions. However, there are no ...

journal_title：Immunology and cell biology

authors： El-Nefiawy N,Abdel-Hakim K,Kanayama N,Suganuma N,Terao T

更新日期：2003-10-01 00:00:00

abstract：:Adjuvants are components that when added to subunit antigen (Ag) vaccines boost their immunogenicity and thus immune efficacy. However, there are few adjuvants that are approved for clinical use resulting in a critical need for the development of safe and effective adjuvants for use in both prophylactic and therapeuti...

journal_title：Immunology and cell biology

authors： Maraskovsky E,Schnurr M,Wilson NS,Robson NC,Boyle J,Drane D

更新日期：2009-07-01 00:00:00

abstract：:Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized the programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, and investigated their influence on helper T (Th) cell responses. Although a...

journal_title：Immunology and cell biology

authors： Tavukcuoglu E,Horzum U,Yilmaz KB,Esendagli G

更新日期：2020-02-01 00:00:00

abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

journal_title：Immunology and cell biology

authors： Fernando SL,Britton WJ

更新日期：2006-04-01 00:00:00

abstract：:Epstein-Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong persistence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: latency in B lymphocytes and replication i...

journal_title：Immunology and cell biology

authors： Schmidt CW,Misko IS

更新日期：1995-12-01 00:00:00

abstract：:Deoxyspergualin (DOSP) is a new immunosuppressive agent which probably inhibits various functions of monocytes, B cells and T cells. We examined the effects of deoxyspergualin on cellular cytotoxicity, including cytotoxic T lymphocyte (CTL) mediated killer, natural killer (NK) cell and lymphokine activated killer (LAK...

journal_title：Immunology and cell biology

authors： Kerr PG,Atkins RC

更新日期：1991-06-01 00:00:00

abstract：:Retinoic acid (RA) in the steady state enhances induction of Foxp3(+) regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby maintaining tolerance, but can in inflammatory conditions promote effector Th1 and Th17 cells that mediate inflammation. IL-17-producing γδ T cells have recently b...

journal_title：Immunology and cell biology

authors： Raverdeau M,Breen CJ,Misiak A,Mills KH

更新日期：2016-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease affecting predominantly motor neurons in the spinal cord and motor cortex. Neurodegeneration in ALS is accompanied by a well-characterized neuroinflammatory reaction within the central nervous system and, as described more recentl...

journal_title：Immunology and cell biology

authors： Zondler L,Feiler MS,Freischmidt A,Ruf WP,Ludolph AC,Danzer KM,Weishaupt JH

更新日期：2017-02-01 00:00:00

abstract：:T cell proliferative responses to rye and Bermuda grass pollen allergens have been studied in a series of 51 atopic and 18 non-atopic subjects. Mean T cell responses were higher in the atopic group than in the non-atopic group (P < 0.001), and there was a strong correlation between the magnitude of reaction in the T c...

journal_title：Immunology and cell biology

authors： Blaher B,McCluskey J,Puy R,Czarny D,Rolland JM

更新日期：1995-02-01 00:00:00

abstract：:PVG rats are resistant to actively induced experimental autoimmune encephalomyelitis (EAE) and this appears to be directly related to high and sustained systemic levels of reactive nitrogen intermediates(RNI) following sensitization for EAE when compared to the highly susceptible Lewis rat. An apparent cellular basis ...

journal_title：Immunology and cell biology

authors： Staykova MA,Cowden W,Willenborg DO

更新日期：2002-04-01 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapy has recently demonstrated a great potential for clinical applications; however, additional progress in the methods of tumor-specific antigen delivery to DCs is necessary for the further development of anti-tumor vaccines. To this end, a capsid-optimized adeno-associated virus se...

journal_title：Immunology and cell biology

authors： Pandya J,Ortiz L,Ling C,Rivers AE,Aslanidi G

更新日期：2014-02-01 00:00:00

abstract：:The recognition of T cell receptors (TCR) by purified major histocompatibility complex (MHC) class II-peptide complexes in the absence of costimulatory signals leads to the induction of T cell non-responsiveness or anergy. In a recent study using human T cell clones, it was observed that prolonged incubation of restin...

journal_title：Immunology and cell biology

authors： Arimilli S,Mumm JB,Nag B

更新日期：1996-02-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in t...

journal_title：Immunology and cell biology

authors： Körner H,Sedgwick JD

更新日期：1996-10-01 00:00:00

abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

journal_title：Immunology and cell biology

authors： Wilson NS,Villadangos JA

更新日期：2004-02-01 00:00:00

abstract：:Three murine monoclonal antibodies (BC1, BC2 and BC3) were developed against human milk fat globule membrane (HMFGM). By immunoperoxidase staining, it was found that the antigenic determinants had a predominant distribution in breast cancer tissue. In addition, the antibodies reacted preferentially with mucin derived ...

journal_title：Immunology and cell biology

authors： Xing PX,Tjandra JJ,Stacker SA,Teh JG,Thompson CH,McLaughlin PJ,McKenzie IF

更新日期：1989-06-01 00:00:00

abstract：:Previous studies established that the high density (resting) natural killer (NK) cell subset (R-NK) of peripheral blood NK cells is unresponsive to interleukin-2 (IL-2) but can be induced to proliferate when cultured with gamma-irradiated malignant melanoma (MM-170) cells or mitomycin-C-treated activated T cells in th...

journal_title：Immunology and cell biology

authors： Warren HS,Kinnear BF,Skipsey LJ

更新日期：1993-04-01 00:00:00

abstract：:The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-K...

journal_title：Immunology and cell biology

authors： van Nieuwenhuijze AE,Cauwe B,Klatt D,Humblet-Baron S,Liston A

更新日期：2015-11-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...

journal_title：Immunology and cell biology

authors： Abdel-Nour M,Tsalikis J,Kleinman D,Girardin SE

更新日期：2014-04-01 00:00:00