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Lpr-induced systemic autoimmunity is unaffected by mast cell deficiency.

Abstract：

:The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-Kit(W-sh/W-sh) (Wsh) mice, resulting in mast cell deficiency. The offspring from this cross (Lpr/Wsh mice) developed symptoms of lupus of the same severity as B6(lpr/lpr) mice. Loss of mast cells on the Lpr background did not alter autoantibody production, proteinuria, the composition of T and B cell populations or autoimmune pathology. Reduced c-Kit expression did drive expanded splenomegaly and impeded interleukin-4 production by CD4(+) cells, suggesting minor functions for mast cells. In general, we conclude that mast cell deficiency and c-Kit deficiency do not play a role in the pathogenesis of lupus in B6(lpr/lpr) mice.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

van Nieuwenhuijze AE,Cauwe B,Klatt D,Humblet-Baron S,Liston A

doi

10.1038/icb.2015.49

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

841-8

issue

10

eissn

0818-9641

issn

1440-1711

pii

icb201549

journal_volume

93

pub_type

杂志文章

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