Macrophages and nitric oxide as the possible cellular and molecular basis for strain and gender differences in susceptibility to autoimmune central nervous system inflammation.

abstract：:Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...

journal_title：Immunology and cell biology

authors： Biswas R,Mukherjee S,Sinha D,Ghosh AK,Biswas T

更新日期：2014-04-01 00:00:00

abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

journal_title：Immunology and cell biology

authors： Ohki K,Amano F,Yamamoto S,Kohashi O

更新日期：1999-04-01 00:00:00

abstract：:For the past 20 years footrot vaccines have evolved from simple bacterins to highly specific recombinant DNA (rDNA) fimbrial vaccines. The development of these vaccines has left a trail of discoveries, challenges and solutions; these processes continue as we move closer to understanding the requirements of a footrot v...

journal_title：Immunology and cell biology

authors： O'Meara TJ,Egerton JR,Raadsma HW

更新日期：1993-10-01 00:00:00

abstract：:The iscom is a delivery system, designed for both parenteral and mucosal modes of administration, for both antigens and adjuvants, components which are interchangeable. By the parenteral route a prominent systemic Th1 type of response is evoked, but the mucosal immunoglobulin A (IgA) response was insignificant. Intran...

journal_title：Immunology and cell biology

authors： Morein F,Bengtsson KL

更新日期：1998-08-01 00:00:00

abstract：:During an allergic inflammatory response in the airway, if a failure of the epithelial cell barrier occurs before the systemic immune response is triggered by allergens, more allergens can invade. Using a rat model of asthma, we previously found that mucosal mast cells, which localise to the epithelial layer of the ai...

journal_title：Immunology and cell biology

authors： Liu S,Shudou M,Maeyama K

更新日期：2011-02-01 00:00:00

abstract：:In the developing forebrain, mounting evidence suggests that neural stem cell proliferation and differentiation is regulated by growth factors. In vitro in the presence of serum, stem cell proliferation is predominantly mediated by fibroblast growth factor-2 (FGF-2) whereas neuronal differentiation can be triggered by...

journal_title：Immunology and cell biology

authors： Bartlett PF,Brooker GJ,Faux CH,Dutton R,Murphy M,Turnley A,Kilpatrick TJ

更新日期：1998-10-01 00:00:00

abstract：:Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein-based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through...

journal_title：Immunology and cell biology

authors： Stewart TJ,Fernando GJ,Frazer IH,Leggatt GR

更新日期：2004-10-01 00:00:00

abstract：:Antigen presentation by enterocytes isolated from the rat small bowel was studied by using T cell proliferation, and immunoregulatory function in an antigen-driven culture system, as indicator systems. Lymph node T cells obtained from rats immunized with ovalbumin (OA) failed to divide when cultured for 4 days in the ...

journal_title：Immunology and cell biology

authors： Pang G,Clancy R,Saunders H

更新日期：1990-12-01 00:00:00

abstract：:Interleukin (IL)-9-producing CD4(+) T cells are a novel subset of T helper (Th) cells that develops independently of the Th1, Th2, Th17 and regulatory T-cell lineages. Similar to the murine model, transforming growth factor (TGF)-beta and IL-4 directed human naive CD4(+) T cells to produce IL-9. Whereas IL-4 suppresse...

journal_title：Immunology and cell biology

authors： Wong MT,Ye JJ,Alonso MN,Landrigan A,Cheung RK,Engleman E,Utz PJ

更新日期：2010-08-01 00:00:00

abstract：:The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary r...

journal_title：Immunology and cell biology

authors： de Jong BG,IJspeert H,Marques L,van der Burg M,van Dongen JJ,Loos BG,van Zelm MC

更新日期：2017-10-01 00:00:00

abstract：:By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

journal_title：Immunology and cell biology

authors： Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

更新日期：1993-08-01 00:00:00

abstract：:Infections caused by group A streptococcus (GAS) represent a public health problem in both developing and developed countries. The current available methods of prevention are either inadequate or ineffective, which is highlighted by the resurgence in invasive GAS infections over the past two decades. The management of...

journal_title：Immunology and cell biology

authors： Pandey M,Sekuloski S,Batzloff MR

更新日期：2009-07-01 00:00:00

abstract：:Respiratory syncytial virus causes lower respiratory tract infections in infancy and old age, affecting also immunocompromised patients. The viral fusion protein is an important vaccine candidate eliciting antibody and cell-mediated immune responses. CD8(+) cytotoxic T lymphocytes (CTLs) are known to have a role in bo...

journal_title：Immunology and cell biology

authors： Johnstone C,Ramos M,García-Barreno B,López D,Melero JA,Del Val M

更新日期：2012-11-01 00:00:00

abstract：:Th-cell differentiation is highly influenced by the local cytokine environment. Although cytokines such as IL-12 and IL-4 are known to polarize the Th-cell response towards Th1 or Th2, respectively, it is not known whether these cytokines instruct the developmental fate of uncommitted Th cells or select cells that hav...

journal_title：Immunology and cell biology

authors： Jansson A,Fagerlind M,Karlsson D,Nilsson P,Cooley M

更新日期：2006-04-01 00:00:00

abstract：:Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing several inhibitors. A novel peroxidase detection system was used and te...

journal_title：Immunology and cell biology

authors： Shuler RL,Owen CS

更新日期：1993-02-01 00:00:00

abstract：:Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT). In this report, we track inhaled antigen in normal mice for 7 days and find that while it is cleared from the airways, inhaled antigen persists in peripheral lung tissue and the draining lymph nodes (DLNs). The persisten...

journal_title：Immunology and cell biology

authors： Wikstrom ME,Batanero E,Judd SR,Wiqvist K,Holt PG,Stumbles PA

更新日期：2010-08-01 00:00:00

abstract：:Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the pheno...

journal_title：Immunology and cell biology

authors： Gámez-Díaz L,Neumann J,Jäger F,Proietti M,Felber F,Soulas-Sprauel P,Perruzza L,Grassi F,Kögl T,Aichele P,Kilimann M,Grimbacher B,Jung S

更新日期：2017-10-01 00:00:00

abstract：:The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases such as diabetes mellitus have recently been associated with a disequilibrium between Id(+) and anti-Id Abs. However, it is unknown how Abs carrying complementa...

journal_title：Immunology and cell biology

authors： Jacobsen JT,Lunde E,Sundvold-Gjerstad V,Munthe LA,Bogen B

更新日期：2010-07-01 00:00:00

abstract：:This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-se...

journal_title：Immunology and cell biology

authors： Blanden RV

更新日期：1995-02-01 00:00:00

abstract：:NK cells from three donors with a NK (CD3- CD56+ CD16+) lymphocytosis of unknown aetiology showed differential expression of CD45R0, an isoform of CD45 not expressed by NK cells from normal donors unless stimulated to proliferate in vitro. For donor FC, 60% of NK cells expressed CD45R0 over a 16 month period during wh...

journal_title：Immunology and cell biology

authors： Warren HS,Kinnear BF,Skipsey LJ,Pembrey RG

更新日期：1994-12-01 00:00:00

abstract：:The pathogenesis of autoimmune disease remains an enigma. Here, the condition is analysed from an evolutionary standpoint, and the thesis developed that viruses, in particular retroviruses, are important to our evolution, and that their inappropriate re-expression by repetitive (? ischaemic) cell damage in individuals...

journal_title：Immunology and cell biology

authors： Boyd GW

更新日期：1997-10-01 00:00:00

abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...

journal_title：Immunology and cell biology

authors： Chin J,Turner B,Barchia I,Mullbacher A

更新日期：2000-02-01 00:00:00

abstract：:There has been a tremendous explosion in the area of DNA vaccine research over the last 4 years, particularly in relation to antiviral vaccines. This report discusses the development and application of this new technology with regard to parasitic infections. Progress has been made towards the development of a vaccine ...

journal_title：Immunology and cell biology

authors： Kalinna BH

更新日期：1997-08-01 00:00:00

abstract：:Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...

journal_title：Immunology and cell biology

authors： Coquet JM,Rausch L,Borst J

更新日期：2015-10-01 00:00:00

abstract：:The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to autoantigens and local immunosuppressive milieu contribute to the testicular immune privilege. Testicular immunosuppression has been intensively studied, but information on...

journal_title：Immunology and cell biology

authors： Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

更新日期：2015-03-01 00:00:00

abstract：:Influx of Ca2+ via Ca2+ channels is the major step triggering exocytosis of pituitary somatotropes to release growth hormone (GH). Voltage-gated Ca2+ and K+ channels, the primary determinants of the influx of Ca2+, are regulated by GH-releasing hormone (GHRH) through G-protein-coupled intracellular signalling systems....

journal_title：Immunology and cell biology

authors： Chen C,Xu R,Clarke IJ,Ruan M,Loneragan K,Roh SG

更新日期：2000-08-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies ...

journal_title：Immunology and cell biology

authors： Shibata T,Ato M

更新日期：2017-11-01 00:00:00

abstract：:T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC ...

journal_title：Immunology and cell biology

authors： Zanker D,Quinn K,Waithman J,Lata R,Murphy R,La Gruta NL,Chen W

更新日期：2015-05-01 00:00:00

abstract：:Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosphatase 1 (SHP-1, Pt...

journal_title：Immunology and cell biology

authors： Watson HA,Dolton G,Ohme J,Ladell K,Vigar M,Wehenkel S,Hindley J,Mohammed RN,Miners K,Luckwell RA,Price DA,Matthews RJ,Ager A

更新日期：2016-09-01 00:00:00

abstract：:Multiple levels of regulation of collagenase (matrix metalloproteinase 1; MMP-1), have been demonstrated in a clonal rat epithelial cell line (A5P/B10). Secreted enzyme could not be demonstrated in culture medium from A5P/B10 cells but, using antibodies specific for collagenase, the enzyme was detected within the cyto...

journal_title：Immunology and cell biology

authors： Whitelock JM,Paine ML,Gibbins JR,Kefford RF,O'Grady RL

更新日期：1993-02-01 00:00:00