Abstract:
:Antigen presentation by enterocytes isolated from the rat small bowel was studied by using T cell proliferation, and immunoregulatory function in an antigen-driven culture system, as indicator systems. Lymph node T cells obtained from rats immunized with ovalbumin (OA) failed to divide when cultured for 4 days in the presence of freshly isolated Ia+ enterocytes and OA. However, cell division was noted when enterocytes were removed after 18 h by Percoll gradient centrifugation, followed by culture of T cells for a further 4 days in the absence of antigen. The failure to divide in the primary culture was due to the secretion by enterocytes of a dialysable non-specific inhibitor. Antigen presentation by enterocytes was specific and was inhibited by monoclonal mouse anti-rat Ia antibody, OX6. An epithelial cell line (REC-2) was established from normal rat small intestine. These cells expressed Ia molecules following incubation with Concanavalin-A stimulated spleen cell supernatant, and were capable of both presenting antigen, and inducing interleukin-2 (IL-2) production, when cultured with primed T cells. Furthermore, Ia+ REC-2 cells functioned as stimulators in a primary mixed lymphocyte reaction (MLR). Both OA-primed T cells activated by enterocytes and antigen, and allogeneic MLR-activated T cells, mediated suppression which was not specific for the initiating antigen. These experiments indicated two mechanisms mediate suppression of cell division in gut mucosa. The contribution of these mechanisms to the control of inflammation at mucosal sites requires investigation.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Pang G,Clancy R,Saunders Hdoi
10.1038/icb.1990.52subject
Has Abstractpub_date
1990-12-01 00:00:00pages
387-96eissn
0818-9641issn
1440-1711journal_volume
68 ( Pt 6)pub_type
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pub_type: 杂志文章,评审
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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