当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.

T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.

Abstract：

:T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC molecules; a phenomenon often termed T-cell receptor (TCR) promiscuity or degeneracy. TCR promiscuity has been attributed to various autoimmune conditions. On the other hand, it is considered a mechanism for a relatively limited TCR repertoire to deal with a potentially much larger antigenic peptide repertoire. Such property has also been utilized to bypass self-tolerance for cancer vaccine development. Although many studies explored such degeneracy for peptide of the same length, few studies reported such properties for peptides of different length. In this study, we finely characterized the CD8(+) T-cell response specific for a 11mer peptide derived from influenza A viral polymerase basic protein 2. The short-term T-cell line, despite possessing highly biased TCR, was able to react with multiple peptides of different length sharing the same core sequence. Out data clearly showed the importance of detailed and quantitative assessments for such T-cell specificity. Our data also emphasize the importance of biochemical demonstration of the naturally presented minimal peptide.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Zanker D,Quinn K,Waithman J,Lata R,Murphy R,La Gruta NL,Chen W

doi

10.1038/icb.2014.113

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

500-7

issue

5

eissn

0818-9641

issn

1440-1711

pii

icb2014113

journal_volume

93

pub_type

杂志文章

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Protection against non-typable Haemophilus influenzae following sensitization of gut associated lymphoid tissue: role of specific antibody and phagocytes.

    abstract：:Rats intestinally immunized with whole killed non-typable Haemophilus influenzae clear this organism from the lungs faster than non-immunized rats. This study investigated the role of antibody and phagocytes in the clearance mechanism. First, dose-response experiments demonstrated that while lowering the dose of non-t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1995.42

    authors： Wallace FJ,Witt CS,Clancy RL,Cripps AW

    更新日期：1995-06-01 00:00:00

  • Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response.

    abstract：:Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2004.01303.x

    authors： Marsland BJ,Camberis M,Le Gros G

    更新日期：2005-02-01 00:00:00

  • Immunoepigenetics: the unseen side of cancer immunoediting.

    abstract：:Cancer immunosurveillance representing, till recently, the explanatory framework relating cancer and the immune system, does not convincingly explain tumor escape. At the beginning of the decade, a new theory emerged, namely the immunoediting theory, and it comprehensively defines the role of the immune system in carc...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/sj.icb.7100006

    authors： Germenis AE,Karanikas V

    更新日期：2007-01-01 00:00:00

  • 3D computation modelling of the influence of cytokine secretion on Th-cell development suggests that negative selection (inhibition of Th1 cells) is more effective than positive selection by IL-4 for Th2 cell dominance.

    abstract：:Th-cell development has been suggested to include selective mechanisms in which certain cytokines select either Th1 or Th2 cells to proliferate and grow. The selective theory is based on the observation that Th2 cells secrete IL-4, a cytokine that promotes Th2 development, whereas Th1 cells secrete interferon-gamma (I...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/sj.icb.7100023

    authors： Jansson A,Harlen M,Karlsson S,Nilsson P,Cooley M

    更新日期：2007-04-01 00:00:00

  • Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals.

    abstract：:Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype ...

    journal_title：Immunology and cell biology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/icb.2013.84

    authors： Westhorpe CL,Maisa A,Spelman T,Hoy JF,Dewar EM,Karapanagiotidis S,Hearps AC,Cheng WJ,Trevillyan J,Lewin SR,Sviridov D,Elliott JH,Jaworowski A,Dart AM,Crowe SM

    更新日期：2014-02-01 00:00:00

  • Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.

    abstract：:Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-reg...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2011.101

    authors： Zhang H,Xiao Y,Zhu Z,Li B,Greene MI

    更新日期：2012-01-01 00:00:00

  • TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO.

    abstract：:FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that express...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.90

    authors： Ye L,Goodall JC,Zhang L,Putintseva EV,Lam B,Jiang L,Liu W,Yin J,Lin L,Li T,Wu X,Yeo G,Shugay M,Chudakov DM,Gaston H,Xu H

    更新日期：2016-03-01 00:00:00

  • A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset.

    abstract：:Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in the induction of anti-viral responses and their role in creating immunologically...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.116

    authors： Bryant C,Fromm PD,Kupresanin F,Clark G,Lee K,Clarke C,Silveira PA,Suen H,Brown R,Newman E,Cunningham I,Ho PJ,Gibson J,Bradstock K,Joshua D,Hart DNj

    更新日期：2016-05-01 00:00:00

  • Life and death in the granuloma: immunopathology of tuberculosis.

    abstract：:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/sj.icb.7100027

    authors： Saunders BM,Britton WJ

    更新日期：2007-02-01 00:00:00

  • Recombinant vaccines against ovine footrot.

    abstract：:For the past 20 years footrot vaccines have evolved from simple bacterins to highly specific recombinant DNA (rDNA) fimbrial vaccines. The development of these vaccines has left a trail of discoveries, challenges and solutions; these processes continue as we move closer to understanding the requirements of a footrot v...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1993.53

    authors： O'Meara TJ,Egerton JR,Raadsma HW

    更新日期：1993-10-01 00:00:00

  • Contributions of an orthopteran to the understanding of neuronal pathfinding.

    abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1995.90

    authors： Sanchez D,Ganfornina MD,Bastiani MJ

    更新日期：1995-12-01 00:00:00

  • FOXO3 is differentially required for CD8+ T-cell death during tolerance versus immunity.

    abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.53

    authors： Wagle MV,Parish IA

    更新日期：2016-10-01 00:00:00

  • Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunity.

    abstract：:Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1996.77

    authors： Körner H,Sedgwick JD

    更新日期：1996-10-01 00:00:00

  • A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease.

    abstract：:Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2017.61

    authors： Shibata T,Ato M

    更新日期：2017-11-01 00:00:00

  • B cells: we need them now more than ever.

    abstract：:The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...

    journal_title：Immunology and cell biology

    pub_type： 社论

    doi：10.1111/imcb.12348

    authors： Deenick EK

    更新日期：2020-07-01 00:00:00

  • Multiple levels of post-transcriptional regulation of collagenase (matrix metalloproteinase 1) in an epithelial cell line.

    abstract：:Multiple levels of regulation of collagenase (matrix metalloproteinase 1; MMP-1), have been demonstrated in a clonal rat epithelial cell line (A5P/B10). Secreted enzyme could not be demonstrated in culture medium from A5P/B10 cells but, using antibodies specific for collagenase, the enzyme was detected within the cyto...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.4

    authors： Whitelock JM,Paine ML,Gibbins JR,Kefford RF,O'Grady RL

    更新日期：1993-02-01 00:00:00

  • Interleukin-2 activates the gamma-interferon gene in newborn mice.

    abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1991.59

    authors： Lipoldová M,Holán V

    更新日期：1991-12-01 00:00:00

  • Tumour eradication with high-dose idarubicin-anti-Ly-2.1 with murine tumour necrosis factor-alpha in mice.

    abstract：:The antitumour efficacy of Ida-anti-Ly-2.1 immunoconjugate in combination with murine TNF-alpha (mTNF-alpha) has been evaluated in a disseminated murine thymic lymphoma model E3. This tumour model shows characteristics similar to lymphoma in humans with widely disseminated tumour in major organs. In vitro both idarubi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1997.39

    authors： Pietersz GA,Bogdanovski M,Li W

    更新日期：1997-06-01 00:00:00

  • Diverse intracellular signalling systems used by growth hormone-releasing hormone in regulating voltage-gated Ca2+ or K channels in pituitary somatotropes.

    abstract：:Influx of Ca2+ via Ca2+ channels is the major step triggering exocytosis of pituitary somatotropes to release growth hormone (GH). Voltage-gated Ca2+ and K+ channels, the primary determinants of the influx of Ca2+, are regulated by GH-releasing hormone (GHRH) through G-protein-coupled intracellular signalling systems....

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2000.00917.x

    authors： Chen C,Xu R,Clarke IJ,Ruan M,Loneragan K,Roh SG

    更新日期：2000-08-01 00:00:00

  • Neuronal antigens modulate the immune response associated with experimental autoimmune encephalomyelitis.

    abstract：:Rats primed with bovine myelin (BM) in complete Freunds adjuvant, develop acute experimental autoimmune encephalomyelitis (EAE). We have previously described that intraperitoneal administration prior to the active induction of the disease of a bovine synaptosomal fraction (BSF) and BM were effective ways of suppressin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2004.01200.x

    authors： Degano AL,Ditamo Y,Roth GA

    更新日期：2004-02-01 00:00:00

  • Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine production.

    abstract：:Human cytomegalovirus (HCMV), the β-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity. Among them, HCMV uses cellular captured genes encoding molecules capable of interfering with the original host function or of fulfilling new immunomodulatory tasks. Here, we report on UL7, ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2011.55

    authors： Engel P,Pérez-Carmona N,Albà MM,Robertson K,Ghazal P,Angulo A

    更新日期：2011-10-01 00:00:00

  • Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile.

    abstract：:During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.22

    authors： Balboa L,Romero MM,Yokobori N,Schierloh P,Geffner L,Basile JI,Musella RM,Abbate E,de la Barrera S,Sasiain MC,Alemán M

    更新日期：2010-10-01 00:00:00

  • CD49b-dependent establishment of T helper cell memory.

    abstract：:CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in the bone marrow (BM). However, the molecular mechanisms of their establishment in the BM and their maintenance remain unclear. We here show that memory CD4 T cells express high levels of CD...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2013.36

    authors： Hanazawa A,Hayashizaki K,Shinoda K,Yagita H,Okumura K,Löhning M,Hara T,Tani-ichi S,Ikuta K,Eckes B,Radbruch A,Tokoyoda K,Nakayama T

    更新日期：2013-09-01 00:00:00

  • Culture-differentiated CD8(+) T cells acquire innate memory-like traits and respond to a pathogen-associated molecule.

    abstract：:Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2013.94

    authors： Biswas R,Mukherjee S,Sinha D,Ghosh AK,Biswas T

    更新日期：2014-04-01 00:00:00

  • Comparison of strategies for the construction of libraries of artificial antibodies.

    abstract：:Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1997.33

    authors： Iba Y,Kurosawa Y

    更新日期：1997-04-01 00:00:00

  • Suppressive effects of serum on the LPS-induced production of nitric oxide and TNF-alpha by a macrophage-like cell line, WEHI-3, are dependent on the structure of polysaccharide chains in LPS.

    abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.1999.00807.x

    authors： Ohki K,Amano F,Yamamoto S,Kohashi O

    更新日期：1999-04-01 00:00:00

  • Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.

    abstract：:Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to deat...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2016.118

    authors： Vasilikos L,Spilgies LM,Knop J,Wong WW

    更新日期：2017-02-01 00:00:00

  • Evaluation of thrombus detection in a rabbit model using a technetium-99m-labelled anti-fibrin monoclonal antibody.

    abstract：:Technetium-99 m (99mTc)-labelled conjugates of an anti-fibrin monoclonal antibody, DD-3B6/22, have been assessed for their detection of vascular thrombi in a rabbit model. DD-3B6/22 binds to a D-dimer epitope present on cross-linked fibrin but absent from the fibrin monomer or fibrinogen. Injection of a 99mTc-labelled...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1992.22

    authors： Lee FT,Milner LJ,Boniface GR,Bautovich GJ,Weedon AR,Bundesen PG,Rylatt DB,Walker KZ

    更新日期：1992-06-01 00:00:00

  • Poloxamer 407-chitosan grafted thermoresponsive hydrogels achieve synchronous and sustained release of antigen and adjuvant from single-shot vaccines.

    abstract：:Sustained-release vaccine delivery systems may enhance the immunogenicity of subunit vaccines and reduce the need for multiple vaccinations. The aim of this study was to develop a thermoresponsive hydrogel using poloxamer 407-chitosan (CP) grafted copolymer as a delivery system for single-shot sustained-release vaccin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.12031

    authors： Bobbala S,Gibson B,Gamble AB,McDowell A,Hook S

    更新日期：2018-07-01 00:00:00

  • Importance of carbohydrate in the interaction of Tamm-Horsfall protein with complement 1q and inhibition of classical complement activation.

    abstract：:Tamm-Horsfall protein (THP) binds strongly to complement 1q (C1q), a key component of the classical complement pathway. The goals of this study were to determine whether THP altered the activation of the classical complement pathway and whether the carbohydrate portion of THP was involved in this glycoprotein's bindin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2006.01434.x

    authors： Rhodes DC

    更新日期：2006-08-01 00:00:00