Abstract:
:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice were able to synthesize a significant level of mRNA for gamma-interferon (gamma-IFN) after stimulation with IL-2, but did not synthesize gamma-IFN upon stimulation with Con-A. Since gamma-IFN is of prime importance for antiviral and fungicidal activities and has complex regulatory functions for the cells of the immune system, we suggest that it could play an important role in the survival of newborns.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Lipoldová M,Holán Vdoi
10.1038/icb.1991.59subject
Has Abstractpub_date
1991-12-01 00:00:00pages
423-6eissn
0818-9641issn
1440-1711journal_volume
69 ( Pt 6)pub_type
杂志文章abstract::Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...
journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
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pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2004-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2015.49
更新日期:2015-11-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1993.9
更新日期:1993-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12310
更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2014.85
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1440-1711.2003.t01-1-01170.x
更新日期:2003-08-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2013.36
更新日期:2013-09-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2012-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1988.35
更新日期:1988-08-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:1989-06-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1998-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2005.01368.x
更新日期:2005-12-01 00:00:00
abstract::There is an urgent need for new, powerful adjuvants suitable for use with sub-unit and peptide vaccines in humans. We have measured the humoral immune response in BALB/c mice to vaccine formulations using recombinant HBsAg antigens, and gamma inulin and alum adjuvants. Using Merck, Sharpe & Dohme (MSD) HBsAg at 10 mic...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1990.15
更新日期:1990-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2008.28
更新日期:2008-07-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1997.14
更新日期:1997-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1997.23
更新日期:1997-04-01 00:00:00
abstract::Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effec...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2014.1
更新日期:2014-03-01 00:00:00