Humoral immune responses in mice using gamma inulin preparations as adjuvants for hepatitis B vaccines.

abstract：:The three modes of antibody production, natural, T independent (TI) and T dependent (TD) are conserved among vertebrate species suggesting an important role for each in protection against pathogens. Here, I use an artificial 'universe' to argue that the three modes of antibody production represent layers that evolved ...

journal_title：Immunology and cell biology

authors： Hodgkin PD

更新日期：1997-12-01 00:00:00

abstract：:The mucosal system is the first line of defense against many pathogens. It is continuously exposed to dietary and microbial antigens, and thus the host must maintain a homeostatic environment between commensal microbiota and pathogenic infections. Following infections and inflammatory events, a rapid innate immune res...

journal_title：Immunology and cell biology

authors： Mangan NE,Fung KY

更新日期：2012-05-01 00:00:00

abstract：:We recently demonstrated that 17beta-estradiol (E2) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect of E2 on leishmanicidal activity and cytokine production by bone marrow-derived macrophages (BMDMs) f...

journal_title：Immunology and cell biology

authors： Lezama-Dávila CM,Isaac-Márquez AP,Barbi J,Cummings HE,Lu B,Satoskar AR

更新日期：2008-08-01 00:00:00

abstract：:Previous data from this laboratory have shown that fluorescein-specific cytotoxic T cells derived from naive mice are capable of distinguishing between different isomeric forms of the fluorescein hapten, as well as between the iodoacetamido-, isothiocyanate- and dichlorotriazinyl amino-fluorescein derivatives. In this...

journal_title：Immunology and cell biology

authors： Hughes EA,Kinnel G,Wickerham C,Atkeson B,Owen JA

更新日期：1995-04-01 00:00:00

abstract：:This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-se...

journal_title：Immunology and cell biology

authors： Blanden RV

更新日期：1995-02-01 00:00:00

abstract：:The protein composition of Strongyloides ratti infective larvae and adult worms extracted sequentially in water, sodium deoxycholate and sodium dodecyl sulphate (SDS) and their excretory/secretory products were analysed by both one- and two-dimensional SDS-polyacrylamide gel electrophoresis. While many bands common to...

journal_title：Immunology and cell biology

authors： Northern C,Grove DI

更新日期：1987-06-01 00:00:00

abstract：:The NK gene complex (NKC) on mouse chromosome 6 encodes receptors that are expressed on NK cells, such as Ly49H, and is involved in regulating NK cell control of virus infections, such as murine cytomegalovirus (MCMV). In the present study, we investigated the level of allelic heterogeneity in NKC loci in populations ...

journal_title：Immunology and cell biology

authors： Scalzo AA,Manzur M,Forbes CA,Brown MG,Shellam GR

更新日期：2005-04-01 00:00:00

abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

journal_title：Immunology and cell biology

authors： Fernando SL,Britton WJ

更新日期：2006-04-01 00:00:00

abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...

journal_title：Immunology and cell biology

authors： Croker BA,Handman E,Hayball JD,Baldwin TM,Voigt V,Cluse LA,Yang FC,Williams DA,Roberts AW

更新日期：2002-06-01 00:00:00

abstract：:Severe stress decreases the resistance of hosts exposed to microbial infections. As compared with two groups of control mice (normal mice, food-and-water-deprived mice [FWD mice]), restraint-stressed mice (RST mice) were shown to be greatly susceptible to intracerebral growth of Cryptococcus neoformans. The susceptibi...

journal_title：Immunology and cell biology

authors： Shimoda M,Jones VC,Kobayashi M,Suzuki F

更新日期：2006-12-01 00:00:00

abstract：:Adult Nematospiroides dubius excretory-secretory (ES) products were collected from worms cultured in vitro, radiolabelled and separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE). The components were characterized and assessed for molecular weight (MW) after autoradiography and gel staining, for a...

journal_title：Immunology and cell biology

authors： Monroy FG,Adams JH,East IJ,Dobson C

更新日期：1989-04-01 00:00:00

abstract：:Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosphatase 1 (SHP-1, Pt...

journal_title：Immunology and cell biology

authors： Watson HA,Dolton G,Ohme J,Ladell K,Vigar M,Wehenkel S,Hindley J,Mohammed RN,Miners K,Luckwell RA,Price DA,Matthews RJ,Ager A

更新日期：2016-09-01 00:00:00

abstract：:Gαq, the α-subunit of Gq protein, is ubiquitously expressed in mammalian cells. It initially attracted attention for its physiological significance in cardiovascular system. In recent years, studies have also indicated the important roles of Gαq in regulating immunity, supplying us a new insight into the mechanism of ...

journal_title：Immunology and cell biology

authors： Liu Y,Wang D,Li F,Shi G

更新日期：2015-08-01 00:00:00

abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

journal_title：Immunology and cell biology

authors： Sanchez D,Ganfornina MD,Bastiani MJ

更新日期：1995-12-01 00:00:00

abstract：:A murine monoclonal antibody has been used to characterise a 45,000 Da antigen that is associated with the surface membrane of merozoites of the human malaria parasite Plasmodium falciparum. The antigen is a glycoprotein and incorporates myristic acid. ...

journal_title：Immunology and cell biology

authors： Ramasamy R

更新日期：1987-10-01 00:00:00

abstract：:Variola virus, the causative agent of smallpox, is a member of the poxvirus family and one of the most virulent human pathogens known. Although smallpox was eradicated almost 30 years ago, it is not understood why the mortality rates associated with the disease were high, why some patients recovered, and what constitu...

journal_title：Immunology and cell biology

authors： Stanford MM,McFadden G,Karupiah G,Chaudhri G

更新日期：2007-02-01 00:00:00

abstract：:Respiratory syncytial virus causes lower respiratory tract infections in infancy and old age, affecting also immunocompromised patients. The viral fusion protein is an important vaccine candidate eliciting antibody and cell-mediated immune responses. CD8(+) cytotoxic T lymphocytes (CTLs) are known to have a role in bo...

journal_title：Immunology and cell biology

authors： Johnstone C,Ramos M,García-Barreno B,López D,Melero JA,Del Val M

更新日期：2012-11-01 00:00:00

abstract：:Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the m...

journal_title：Immunology and cell biology

authors： Miyara M,Sakaguchi S

更新日期：2011-03-01 00:00:00

abstract：:Asthma is a common and complex inflammatory disease of the airways that remains incurable. Current forms of therapy are long term and may exhibit associated side-effect problems. Major participants in the development of an asthma phenotype include the triggering stimuli such as the allergens themselves, cells such as ...

journal_title：Immunology and cell biology

authors： Ramshaw HS,Woodcock JM,Bagley CJ,McClure BJ,Hercus TR,Lopez AF

更新日期：2001-04-01 00:00:00

abstract：:The utility of T-cell receptor (TCR) transgenic mice in medical research has been considerable, with applications ranging from basic biology all the way to translational and clinical investigations. Crossing of TCR transgenic mice with either recombination-activating gene (RAG)-1 or RAG-2 knockouts is frequently used ...

journal_title：Immunology and cell biology

authors： McGuire HM,Watkins TS,Field M,Taylor S,Yasuyama N,Farmer A,Miles JJ,Fazekas de St Groth B

更新日期：2018-07-01 00:00:00

abstract：:There is increasing evidence that a small percentage of individuals exposed to the hepatitis C virus have the capacity to generate a strong cellular immune response against the virus and avoid persistent infection, and perhaps do so repeatedly after re-exposure. This article reviews the evidence that the responses ide...

journal_title：Immunology and cell biology

authors： Elliot LN,Lloyd AR,Ziegler JB,Ffrench RA

更新日期：2006-06-01 00:00:00

abstract：:Mice infected with Sarcocystis muris showed a significant reduction in plaque-forming cells (PFC) and delayed-type hypersensitivity (DHS) responses to an unrelated protein antigen, bovine gamma-globulin, when compared with uninfected controls. This immunosuppression was observed only when infection preceded immunizati...

journal_title：Immunology and cell biology

authors： Gill HS,Charleston WA,Moriarty KM

更新日期：1988-01-01 00:00:00

abstract：:The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases such as diabetes mellitus have recently been associated with a disequilibrium between Id(+) and anti-Id Abs. However, it is unknown how Abs carrying complementa...

journal_title：Immunology and cell biology

authors： Jacobsen JT,Lunde E,Sundvold-Gjerstad V,Munthe LA,Bogen B

更新日期：2010-07-01 00:00:00

abstract：:Deoxyspergualin (DOSP) is a new immunosuppressive agent which probably inhibits various functions of monocytes, B cells and T cells. We examined the effects of deoxyspergualin on cellular cytotoxicity, including cytotoxic T lymphocyte (CTL) mediated killer, natural killer (NK) cell and lymphokine activated killer (LAK...

journal_title：Immunology and cell biology

authors： Kerr PG,Atkins RC

更新日期：1991-06-01 00:00:00

abstract：:Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...

journal_title：Immunology and cell biology

authors： Tarlinton D

更新日期：2020-07-01 00:00:00

abstract：:In their recent publication, Kuczma and colleagues have provided evidence that advances the relationship between naive T cells, T cell anergy and T regulatory cells. Their findings strengthen the understanding of how these T cell subsets function in relation to self and microbiota-derived epitopes to promote and maint...

journal_title：Immunology and cell biology

authors： Eggenhuizen PJ,Ng BH,Ooi JD

更新日期：2020-12-04 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...

journal_title：Immunology and cell biology

authors： Abdel-Nour M,Tsalikis J,Kleinman D,Girardin SE

更新日期：2014-04-01 00:00:00

abstract：:Th-cell development has been suggested to include selective mechanisms in which certain cytokines select either Th1 or Th2 cells to proliferate and grow. The selective theory is based on the observation that Th2 cells secrete IL-4, a cytokine that promotes Th2 development, whereas Th1 cells secrete interferon-gamma (I...

journal_title：Immunology and cell biology

authors： Jansson A,Harlen M,Karlsson S,Nilsson P,Cooley M

更新日期：2007-04-01 00:00:00

abstract：:We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despi...

journal_title：Immunology and cell biology

authors： Zlatopolskiy A,Laurence J

更新日期：2001-08-01 00:00:00

abstract：:Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...

journal_title：Immunology and cell biology

authors： Ruszala-Mallon V,Silva J,Lumanglas AL,Durr FE,Wang BS

更新日期：1991-02-01 00:00:00