Abstract:
:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like receptor-dependent innate responses and in the activation of T cells and antigen-presenting cells. We also highlight the importance of amino-acid starvation-driven mTOR inhibition in the control of autophagy and intracellular bacterial clearance.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Abdel-Nour M,Tsalikis J,Kleinman D,Girardin SEdoi
10.1038/icb.2014.3subject
Has Abstractpub_date
2014-04-01 00:00:00pages
346-53issue
4eissn
0818-9641issn
1440-1711pii
icb20143journal_volume
92pub_type
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12282
更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/icb.1997.95
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journal_title:Immunology and cell biology
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pub_type: 杂志文章
doi:10.1111/imcb.12033
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
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pub_type: 杂志文章
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更新日期:1989-10-01 00:00:00