An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes.

abstract：:The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cance...

journal_title：Immunology and cell biology

authors： Watkins TS,Miles JJ

更新日期：2020-07-16 00:00:00

abstract：:Sustained-release vaccine delivery systems may enhance the immunogenicity of subunit vaccines and reduce the need for multiple vaccinations. The aim of this study was to develop a thermoresponsive hydrogel using poloxamer 407-chitosan (CP) grafted copolymer as a delivery system for single-shot sustained-release vaccin...

journal_title：Immunology and cell biology

authors： Bobbala S,Gibson B,Gamble AB,McDowell A,Hook S

更新日期：2018-07-01 00:00:00

abstract：:Tamm-Horsfall protein (THP) binds strongly to complement 1q (C1q), a key component of the classical complement pathway. The goals of this study were to determine whether THP altered the activation of the classical complement pathway and whether the carbohydrate portion of THP was involved in this glycoprotein's bindin...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2006-08-01 00:00:00

abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

journal_title：Immunology and cell biology

authors： Chazaud B

更新日期：2016-02-01 00:00:00

abstract：:Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...

journal_title：Immunology and cell biology

authors： Taylor-Robinson AW

更新日期：1997-04-01 00:00:00

abstract：:T lymphocytes are characterized by the use of structurally diverse TCR. The discovery of subsets of canonical T cells that have structurally homogeneous TCR presents an enigma: What antigens do these T cells recognize, and how does their antigen specificity relate to their functions? One subset of canonical T cells is...

journal_title：Immunology and cell biology

authors： Gumperz JE

更新日期：2004-06-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite causative of clinical infections in a wide range of animal hosts. The maturation and activation of splenic conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were studied here in BALB/c mice challenged intraperitoneal with N. caninum tachyzoites. The nu...

journal_title：Immunology and cell biology

authors： Teixeira L,Botelho AS,Mesquita SD,Correia A,Cerca F,Costa R,Sampaio P,Castro AG,Vilanova M

更新日期：2010-01-01 00:00:00

abstract：:Immunization of Lewis rats with guinea-pig myelin basic protein (Gp-MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encep...

journal_title：Immunology and cell biology

authors： Vandenbark AA,Chou YK,Whitham R,Bourdette DN,Offner H

更新日期：1998-02-01 00:00:00

abstract：:A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal di...

journal_title：Immunology and cell biology

authors： Ho ES,O'Neill HC

更新日期：1995-06-01 00:00:00

abstract：:See also: Outstanding Observation by Wirasinha et al., Short Communication by Barnes & Cyster. ...

journal_title：Immunology and cell biology

authors： Robert R,Mackay CR

更新日期：2018-04-01 00:00:00

abstract：:CD8+ T lymphocytes are key effectors in the control of viral diseases and some tumours. In general, the majority of CD8+ T cells recognize a few immunodominant epitopes, but in some circumstances, subdominant specificities may be more relevant as targets for vaccines or immunotherapy. Epstein-Barr virus (EBV)-associat...

journal_title：Immunology and cell biology

authors： Moor RJ,Morrison LE,Moss DJ,Tscharke DC

更新日期：2007-10-01 00:00:00

abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...

journal_title：Immunology and cell biology

authors： Croker BA,Handman E,Hayball JD,Baldwin TM,Voigt V,Cluse LA,Yang FC,Williams DA,Roberts AW

更新日期：2002-06-01 00:00:00

abstract：:Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...

journal_title：Immunology and cell biology

authors： Price P,Cheong KY,Boodhoo A,Witt CS,McCann V,Christiansen FT,Allcock RJ

更新日期：2001-12-01 00:00:00

abstract：:Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...

journal_title：Immunology and cell biology

authors： Coquet JM,Rausch L,Borst J

更新日期：2015-10-01 00:00:00

abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

journal_title：Immunology and cell biology

authors： Wagle MV,Parish IA

更新日期：2016-10-01 00:00:00

abstract：:The secreted hexameric form of the dengue virus (DENV) non-structural protein 1 (NS1) has recently been shown to elicit inflammatory cytokine release and disrupt endothelial cell monolayer integrity. This suggests that circulating NS1 contributes to the vascular leak that plays a major role in the pathology of dengue ...

journal_title：Immunology and cell biology

authors： Modhiran N,Watterson D,Blumenthal A,Baxter AG,Young PR,Stacey KJ

更新日期：2017-05-01 00:00:00

abstract：:Variola virus, the causative agent of smallpox, is a member of the poxvirus family and one of the most virulent human pathogens known. Although smallpox was eradicated almost 30 years ago, it is not understood why the mortality rates associated with the disease were high, why some patients recovered, and what constitu...

journal_title：Immunology and cell biology

authors： Stanford MM,McFadden G,Karupiah G,Chaudhri G

更新日期：2007-02-01 00:00:00

abstract：:Tumour cell heterogeneity is probably a principal cause of treatment failure and represents a formidable barrier for effective antibody-targeted chemotherapy. Idarubicin (Ida), a more potent and less cardiotoxic analogue of daunomycin, has been demonstrated to specifically target and eradicate homogeneous, cloned, mur...

journal_title：Immunology and cell biology

authors： Smyth MJ,Foster HM,Andrew SM,Teh JG,Krauer K,McKenzie IF,Pietersz GA

更新日期：1993-06-01 00:00:00

abstract：:Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Intera...

journal_title：Immunology and cell biology

authors： McCoy KD,Le Gros G

更新日期：1999-02-01 00:00:00

abstract：:Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient...

journal_title：Immunology and cell biology

authors： Ramsbottom KM,Sacirbegovic F,Hawkins ED,Kallies A,Belz GT,Van Ham V,Haynes NM,Durrant MJ,Humbert PO,Russell SM,Oliaro J

更新日期：2016-03-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

journal_title：Immunology and cell biology

authors： Xu Y,Hunt NH,Bao S

更新日期：2007-11-01 00:00:00

abstract：:The molecular interactions between the T-cell receptor (TCR) and peptide-MHC (pMHC) have been elucidated in recent years. Nevertheless, the fact that binding of only slightly different ligands by a TCR, or ligation of the same pMHC at different developmental stages of the T cell, can have opposing consequences, contin...

journal_title：Immunology and cell biology

authors： Regner M

更新日期：2001-04-01 00:00:00

abstract：:Antigen presentation by enterocytes isolated from the rat small bowel was studied by using T cell proliferation, and immunoregulatory function in an antigen-driven culture system, as indicator systems. Lymph node T cells obtained from rats immunized with ovalbumin (OA) failed to divide when cultured for 4 days in the ...

journal_title：Immunology and cell biology

authors： Pang G,Clancy R,Saunders H

更新日期：1990-12-01 00:00:00

abstract：:The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-K...

journal_title：Immunology and cell biology

authors： van Nieuwenhuijze AE,Cauwe B,Klatt D,Humblet-Baron S,Liston A

更新日期：2015-11-01 00:00:00

abstract：:The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases such as diabetes mellitus have recently been associated with a disequilibrium between Id(+) and anti-Id Abs. However, it is unknown how Abs carrying complementa...

journal_title：Immunology and cell biology

authors： Jacobsen JT,Lunde E,Sundvold-Gjerstad V,Munthe LA,Bogen B

更新日期：2010-07-01 00:00:00

abstract：:Infection of mice with the flaviviruses West Nile virus (WNV) and Murray Valley encephalitis (MVE) induces cytolytic T-cell responses which are highly cross-reactive on target cells infected with heterologous flaviviruses. Of C57BL/6 mice infected with low doses (10(2)-10(6) PFU) of either virus, 30-40% develop enceph...

journal_title：Immunology and cell biology

authors： Wang Y,Lobigs M,Lee E,Müllbacher A

更新日期：2004-04-01 00:00:00

abstract：:The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary r...

journal_title：Immunology and cell biology

authors： de Jong BG,IJspeert H,Marques L,van der Burg M,van Dongen JJ,Loos BG,van Zelm MC

更新日期：2017-10-01 00:00:00

abstract：:CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulat...

journal_title：Immunology and cell biology

authors： Jatzek A,Marie Tejera M,Plisch EH,Fero ML,Suresh M

更新日期：2013-02-01 00:00:00

abstract：:Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...

journal_title：Immunology and cell biology

authors： Biswas R,Mukherjee S,Sinha D,Ghosh AK,Biswas T

更新日期：2014-04-01 00:00:00

abstract：:There has been a tremendous explosion in the area of DNA vaccine research over the last 4 years, particularly in relation to antiviral vaccines. This report discusses the development and application of this new technology with regard to parasitic infections. Progress has been made towards the development of a vaccine ...

journal_title：Immunology and cell biology

authors： Kalinna BH

更新日期：1997-08-01 00:00:00