Abstract:
:The molecular interactions between the T-cell receptor (TCR) and peptide-MHC (pMHC) have been elucidated in recent years. Nevertheless, the fact that binding of only slightly different ligands by a TCR, or ligation of the same pMHC at different developmental stages of the T cell, can have opposing consequences, continues to pose intellectual challenges. Kinetic proofreading models, which have at their core the dissociation rates of pMHC from the TCR, are best suited to account for these observations. However, T cells can be triggered by peptides with often minimal homology to the primary immunogenic peptide. This cross-reactivity of the TCR is manifest at several levels, from positive selection of immature thymocytes to homeostasis and antigen-cross- reactive immune responses of mature peripheral T cells. The implications of the high cross-reactivity of T-cell antigen recognition for self-tolerance and T-cell memory are discussed.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Regner Mdoi
10.1046/j.1440-1711.2001.00994.xsubject
Has Abstractpub_date
2001-04-01 00:00:00pages
91-100issue
2eissn
0818-9641issn
1440-1711journal_volume
79pub_type
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journal_title:Immunology and cell biology
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更新日期:2005-02-01 00:00:00
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更新日期:2018-03-25 00:00:00
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1995-02-01 00:00:00
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journal_title:Immunology and cell biology
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更新日期:2017-11-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1994.23
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pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00