The immunomodulatory role of tumor-derived extracellular vesicles in colorectal cancer.

abstract：:Parturition is associated with myometrial and cervical inflammation. The causes and consequences of this inflammatory response are not clear. Mast cells (MCs) are important inducers of allergic and non-allergic inflammation, and their secreted products can induce myometrial contractions. Thus, mast cell activation has...

journal_title：Immunology and cell biology

authors： Menzies FM,Higgins CA,Shepherd MC,Nibbs RJ,Nelson SM

更新日期：2012-03-01 00:00:00

abstract：:The central pathogenic feature of AIDS is the dramatic loss of CD4+ lymphocytes. Despite more than a decade of intense research, the exact mechanism by which HIV causes this is still not understood. A major model for T cell depletion, proposed originally by Ameison and Capron in a report published in 1991, is that HIV...

journal_title：Immunology and cell biology

authors： Jaworowski A,Crowe SM

更新日期：1999-02-01 00:00:00

abstract：:In their recent publication, Kuczma and colleagues have provided evidence that advances the relationship between naive T cells, T cell anergy and T regulatory cells. Their findings strengthen the understanding of how these T cell subsets function in relation to self and microbiota-derived epitopes to promote and maint...

journal_title：Immunology and cell biology

authors： Eggenhuizen PJ,Ng BH,Ooi JD

更新日期：2020-12-04 00:00:00

abstract：:Mucosal mast cells (MMCs) have an important role in allergic inflammation, and effective antagonists are required for their regulation. To discover a possible mechanism of controlling the activation of MMCs, we investigated the expression and function of syntaxin4, one of the soluble membrane N-ethylmaleimide-sensitiv...

journal_title：Immunology and cell biology

authors： Liu S,Nugroho AE,Shudou M,Maeyama K

更新日期：2012-03-01 00:00:00

abstract：:The surface phenotype of T cells reflects both their relative maturity and their activation state. To determine the pattern of surface markers characteristic of activated T cells, purified mature T cells were stimulated in vitro for periods of 0.5-5 days with Concanavalin-A (Con-A) or phorbol myristic acetate (PMA) an...

journal_title：Immunology and cell biology

authors： Kelly K,Shortman K,Scollay R

更新日期：1988-08-01 00:00:00

abstract：:Mucosal addressin cell adhesion molecule (MAdCAM-1) is a key player in mediating the infiltration of leucocytes into chronically inflamed tissues. Five anti-MAdCAM-1 monoclonal antibodies (mAb), designated 17F5, 201F7, 314G8, 377D10 and 355G8, were generated by fusion of P3 x 63Ag8.653 myeloma cells with spleen cells ...

journal_title：Immunology and cell biology

authors： Leung E,Lehnert KB,Kanwar JR,Yang Y,Mon Y,McNeil HP,Krissansen GW

更新日期：2004-08-01 00:00:00

abstract：:The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2002-12-01 00:00:00

abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

journal_title：Immunology and cell biology

authors： Fernando SL,Britton WJ

更新日期：2006-04-01 00:00:00

abstract：:Natural killer (NK) cells are part of the first line defense against tumors, parasites and virus-infected cells. Therefore, factors that control NK-cell numbers and their function are important. CD27 is constitutively expressed on NK cells and its expression correlates with sequential phases in NK-cell development, di...

journal_title：Immunology and cell biology

authors： De Colvenaer V,Taveirne S,Delforche M,De Smedt M,Vandekerckhove B,Taghon T,Boon L,Plum J,Leclercq G

更新日期：2011-10-01 00:00:00

abstract：:Here we examine the use of glycopeptides containing tumour-associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent results suggest that CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC-restricted fashion. The ThomsenFriedenreich antigen (TF), ...

journal_title：Immunology and cell biology

authors： Xu Y,Sette A,Sidney J,Gendler SJ,Franco A

更新日期：2005-08-01 00:00:00

abstract：:The ability of a tunicate immunomodulatory protein, tunIL1, to interact with mammalian cells was investigated. TunIL1 is known to regulate inflammatory defence reactions in tunicates and to stimulate the proliferation of mammalian thymocytes. In the current study, tunIL1 was shown to enchance L929 fibroblast prolifera...

journal_title：Immunology and cell biology

authors： Raftos D

更新日期：1996-02-01 00:00:00

abstract：:In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA sequencing, and the state-of-the-art cytometry by time of flight (CyTOF) mass cytometer have allowed a detailed analysis of the sub-composition of different organs from the bone marrow hematopoietic compartment to the brain. T...

journal_title：Immunology and cell biology

authors： Proserpio V,Lönnberg T

更新日期：2016-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease affecting predominantly motor neurons in the spinal cord and motor cortex. Neurodegeneration in ALS is accompanied by a well-characterized neuroinflammatory reaction within the central nervous system and, as described more recentl...

journal_title：Immunology and cell biology

authors： Zondler L,Feiler MS,Freischmidt A,Ruf WP,Ludolph AC,Danzer KM,Weishaupt JH

更新日期：2017-02-01 00:00:00

abstract：:A clone of cells secreting an antibody to an epidermal antigen was generated from a patient with a blistering skin lesion. Although produced by fusion of human lymphocytes to a HAT-sensitive myeloma, this clone of cells did not have characteristics of a hybridoma. A true hybridoma was produced by fusion of this clone ...

journal_title：Immunology and cell biology

authors： Hohmann AW,Coleman M,Comacchio RM,Skinner JM,Bradley J

更新日期：1988-01-01 00:00:00

abstract：:One of the major limitations for cancer immunotherapy is related to the frequent existence of an intra-tumoral immunosuppressive environment, to which STAT3 (Signal transducer and activator of transcription-3) activation in tumor and dendritic cells (DCs) are believed to contribute. In this study, we tested the hypoth...

journal_title：Immunology and cell biology

authors： Molavi O,Ma Z,Hamdy S,Lai R,Lavasanifar A,Samuel J

更新日期：2008-08-01 00:00:00

abstract：:Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...

journal_title：Immunology and cell biology

authors： Taylor-Robinson AW

更新日期：1997-04-01 00:00:00

abstract：:The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellul...

journal_title：Immunology and cell biology

authors： Zhan Y,Kong I,Chopin M,Macri C,Zhang JG,Xie J,Nutt SL,O'Keeffe M,Hawkins ED,Morand EF,Lew AM

更新日期：2020-03-01 00:00:00

abstract：:The mechanisms involved in the inhibition of growth of a human B lymphoma cell line, B104, by anti-MHC class II antibodies (Ab) were compared with those in anti-IgM Ab-induced B104 growth inhibition. Two anti-MHC class II Ab, L227 and 2.06, inhibited the growth of B104 cells, although 2.06, but not L227, needed to be ...

journal_title：Immunology and cell biology

authors： Higaki Y,Hata D,Kanazashi S,Horiguchi Y,Yamaoka K,Ohshima Y,Kim KM,Heike T,Mayumi M

更新日期：1994-06-01 00:00:00

abstract：:There is little evidence that cutaneous dendritic cells (DC), including epidermal Langerhans cells (LC), can induce immunity to UV radiation (UVR)-induced skin tumours. Here, it is shown that cells within skin can induce protective antitumour immunity against a UVR-induced fibrosarcoma. Transplantation of the skin ove...

journal_title：Immunology and cell biology

authors： Sluyter R,Yuen KS,Halliday GM

更新日期：2001-02-01 00:00:00

abstract：:Multiple levels of regulation of collagenase (matrix metalloproteinase 1; MMP-1), have been demonstrated in a clonal rat epithelial cell line (A5P/B10). Secreted enzyme could not be demonstrated in culture medium from A5P/B10 cells but, using antibodies specific for collagenase, the enzyme was detected within the cyto...

journal_title：Immunology and cell biology

authors： Whitelock JM,Paine ML,Gibbins JR,Kefford RF,O'Grady RL

更新日期：1993-02-01 00:00:00

abstract：:There has been a tremendous explosion in the area of DNA vaccine research over the last 4 years, particularly in relation to antiviral vaccines. This report discusses the development and application of this new technology with regard to parasitic infections. Progress has been made towards the development of a vaccine ...

journal_title：Immunology and cell biology

authors： Kalinna BH

更新日期：1997-08-01 00:00:00

abstract：:There is a need for non-living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Here we describe our experience with lipophilic immune-stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A. When given orally, ISCOMs containin...

journal_title：Immunology and cell biology

authors： Smith RE,Donachie AM,Mowat AM

更新日期：1998-06-01 00:00:00

abstract：:This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-se...

journal_title：Immunology and cell biology

authors： Blanden RV

更新日期：1995-02-01 00:00:00

abstract：:Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient...

journal_title：Immunology and cell biology

authors： Ramsbottom KM,Sacirbegovic F,Hawkins ED,Kallies A,Belz GT,Van Ham V,Haynes NM,Durrant MJ,Humbert PO,Russell SM,Oliaro J

更新日期：2016-03-01 00:00:00

abstract：:The glycoprotein processing inhibitor castanospermine (CS) and the monosaccharide mannose-6-phosphate (M6P), as well as some sulfated polysaccharides (SPS), have been shown to inhibit inflammation in rat models of experimental autoimmune encephalomyelitis and adjuvant-induced arthritis. Here, the anti-inflammatory eff...

journal_title：Immunology and cell biology

authors： Bartlett MR,Warren HS,Cowden WB,Parish CR

更新日期：1994-10-01 00:00:00

abstract：:The 120-kDa protein product of the c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic protein that is especially abundant in the thymus, indicating an important role for Cbl in thymic signalling. c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple...

journal_title：Immunology and cell biology

authors： Thien CB,Langdon WY

更新日期：1998-10-01 00:00:00

abstract：:Peyer's patches (PP) are important inductive sites for the mucosal immune response. It is well known that lymphocytes that migrate into PP are mainly of T-cell lineage from thymus-derived cells (i.e. alphabetaTCR(high) cells). In this study, we further characterized the properties of PP lymphocytes in mice using a mou...

journal_title：Immunology and cell biology

authors： Takahashi S,Kawamura T,Kanda Y,Taniguchi T,Nishizawa T,Iiai T,Hatakeyama K,Abo T

更新日期：2005-10-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

journal_title：Immunology and cell biology

authors： Simone LC,Wang X,Tuli A,Solheim JC

更新日期：2010-01-01 00:00:00

abstract：:Elucidating pathways that regulate cytokine production in the context of autoimmune disease will likely lead to the development of novel therapeutics. Herein, we review data suggesting that microRNAs (miRs) represent one such level of regulatory activity, with particular emphasis on the pathogenesis of rheumatoid arth...

journal_title：Immunology and cell biology

authors： Baxter D,McInnes IB,Kurowska-Stolarska M

更新日期：2012-03-01 00:00:00

abstract：:Listeria monocytogenes is the causative agent of infections like sepsis and meningitis, especially in immunocompromised hosts. Human macrophages are able to phagocytose and digest L. monocytogenes but IL-4 prevents human macrophages from killing the bacteria, the mechanisms of which are unknown. In the present study, ...

journal_title：Immunology and cell biology

authors： Neumann K,Eppler E,Filgueira L,Groscurth P,Gasal E,Schaffner A,Schoedon G,Schneemann M

更新日期：2003-12-01 00:00:00