Production of a polyspecific human monoclonal antibody reacting with an epidermal antigen.

abstract：:Adjuvants are components that when added to subunit antigen (Ag) vaccines boost their immunogenicity and thus immune efficacy. However, there are few adjuvants that are approved for clinical use resulting in a critical need for the development of safe and effective adjuvants for use in both prophylactic and therapeuti...

journal_title：Immunology and cell biology

authors： Maraskovsky E,Schnurr M,Wilson NS,Robson NC,Boyle J,Drane D

更新日期：2009-07-01 00:00:00

abstract：:Today's generally accepted view of the self-nonself discrimination was voiced by Miller(1) in 2004 in a thought-provoking essay. In spite of its popularity, this position has its limitations, which are analyzed here with a view toward establishing an interactive discussion that hopefully will culminate in agreed upon ...

journal_title：Immunology and cell biology

authors： Cohn M

更新日期：2009-02-01 00:00:00

abstract：:This paper reports the production and characterization of three monoclonal antibodies (mAb) recognizing ovine vascular cell adhesion molecule-1 (VCAM-1). The mAb were raised against sheep umbilical vein endothelial cells (ShUVEC) and flow cytometric analysis demonstrated that one mAb, QE4G9, was cross-reactive with hu...

journal_title：Immunology and cell biology

authors： Grooby WL,Krishnan R,Russ GR

更新日期：1997-12-01 00:00:00

abstract：:Influx of Ca2+ via Ca2+ channels is the major step triggering exocytosis of pituitary somatotropes to release growth hormone (GH). Voltage-gated Ca2+ and K+ channels, the primary determinants of the influx of Ca2+, are regulated by GH-releasing hormone (GHRH) through G-protein-coupled intracellular signalling systems....

journal_title：Immunology and cell biology

authors： Chen C,Xu R,Clarke IJ,Ruan M,Loneragan K,Roh SG

更新日期：2000-08-01 00:00:00

abstract：:The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...

journal_title：Immunology and cell biology

authors： Zanker D,Pang K,Oveissi S,Lu C,Faou P,Nowell C,Mbogo GW,Carotta S,Quillici C,Karupiah G,Hibbs ML,Nutt SL,Neeson P,Puthalakath H,Chen W

更新日期：2018-10-01 00:00:00

abstract：:Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...

journal_title：Immunology and cell biology

authors： Gregory KJ,Morin SM,Kubosiak A,Ser-Dolansky J,Schalet BJ,Jerry DJ,Schneider SS

更新日期：2020-11-01 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapy has recently demonstrated a great potential for clinical applications; however, additional progress in the methods of tumor-specific antigen delivery to DCs is necessary for the further development of anti-tumor vaccines. To this end, a capsid-optimized adeno-associated virus se...

journal_title：Immunology and cell biology

authors： Pandya J,Ortiz L,Ling C,Rivers AE,Aslanidi G

更新日期：2014-02-01 00:00:00

abstract：:Mycobacterium tuberculosis uses numerous mechanisms to avoid elimination by the infected host. In this study, we investigated the possibility whether, similar to other pathogens, M. tuberculosis exploits natural CD4+ CD25+ T-regulatory cells (Treg) to suppress the effector function of responding host lymphocytes, thus...

journal_title：Immunology and cell biology

authors： Quinn KM,McHugh RS,Rich FJ,Goldsack LM,de Lisle GW,Buddle BM,Delahunt B,Kirman JR

更新日期：2006-10-01 00:00:00

abstract：:Asthma is a common and complex inflammatory disease of the airways that remains incurable. Current forms of therapy are long term and may exhibit associated side-effect problems. Major participants in the development of an asthma phenotype include the triggering stimuli such as the allergens themselves, cells such as ...

journal_title：Immunology and cell biology

authors： Ramshaw HS,Woodcock JM,Bagley CJ,McClure BJ,Hercus TR,Lopez AF

更新日期：2001-04-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

journal_title：Immunology and cell biology

authors： Xu Y,Hunt NH,Bao S

更新日期：2007-11-01 00:00:00

abstract：:The mouse peritoneal cavity contains a unique population of B cells (Bla) with a high IgM/low IgD ratio, CD5+ (Ly1), MAC-1 + phenotype. These cells arise early in ontogeny, utilize a limited repertoire of immunoglobulin V genes, produce polyreactive IgM antibodies and have been implicated as the source of many auto-re...

journal_title：Immunology and cell biology

authors： Beagley KW,Murray AM,McGhee JR,Eldridge JH

更新日期：1995-10-01 00:00:00

abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

journal_title：Immunology and cell biology

authors： Chazaud B

更新日期：2016-02-01 00:00:00

abstract：:The present report provides the first extensive characterization of the OT-I TCR transgenic line, which produces MHC class I-restricted, ovalbumin-specific, CD8+ T cells (OT-I cells). These cells are shown to be positively selected in vivo in H-2b C57BL/6 mice and in bm5 mice, which express the Kbm5 mutant molecule. I...

journal_title：Immunology and cell biology

authors： Clarke SR,Barnden M,Kurts C,Carbone FR,Miller JF,Heath WR

更新日期：2000-04-01 00:00:00

abstract：:It has been described that polymorphonuclear neutrophils (PMNs) enhance the replication of CC-chemokine receptor 5/macrophage-tropic (R5) HIV in cultures of monocyte-derived macrophages (MDMs). In this study, the inhibitory effect of glycyrrhizin (GL) on R5 HIV replication influenced by PMNs was investigated in MDM cu...

journal_title：Immunology and cell biology

authors： Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F

更新日期：2009-10-01 00:00:00

abstract：:γδ T cells producing interleukin-17A (γδT17) are thought to develop spontaneously in the thymus and to be maintained in the periphery. Previous studies suggested a role for T-helper 17 (Th17) cells in the maintenance of γδT17 via the expression of transforming growth factor-β1 (TGFβ1). However, we have previously foun...

journal_title：Immunology and cell biology

authors： Gupta PK,Wagner SR,Wu Q,Shilling RA

更新日期：2017-03-01 00:00:00

abstract：:Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory...

journal_title：Immunology and cell biology

authors： Almudevar A

更新日期：2017-10-01 00:00:00

abstract：:Elucidating pathways that regulate cytokine production in the context of autoimmune disease will likely lead to the development of novel therapeutics. Herein, we review data suggesting that microRNAs (miRs) represent one such level of regulatory activity, with particular emphasis on the pathogenesis of rheumatoid arth...

journal_title：Immunology and cell biology

authors： Baxter D,McInnes IB,Kurowska-Stolarska M

更新日期：2012-03-01 00:00:00

abstract：:Severe stress decreases the resistance of hosts exposed to microbial infections. As compared with two groups of control mice (normal mice, food-and-water-deprived mice [FWD mice]), restraint-stressed mice (RST mice) were shown to be greatly susceptible to intracerebral growth of Cryptococcus neoformans. The susceptibi...

journal_title：Immunology and cell biology

authors： Shimoda M,Jones VC,Kobayashi M,Suzuki F

更新日期：2006-12-01 00:00:00

abstract：:Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype ...

journal_title：Immunology and cell biology

authors： Westhorpe CL,Maisa A,Spelman T,Hoy JF,Dewar EM,Karapanagiotidis S,Hearps AC,Cheng WJ,Trevillyan J,Lewin SR,Sviridov D,Elliott JH,Jaworowski A,Dart AM,Crowe SM

更新日期：2014-02-01 00:00:00

abstract：:T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC ...

journal_title：Immunology and cell biology

authors： Zanker D,Quinn K,Waithman J,Lata R,Murphy R,La Gruta NL,Chen W

更新日期：2015-05-01 00:00:00

abstract：:The Australian populations of rainbow trout (Onchorhynchus mykiss) and Atlantic salmon (Salmo salar) were found to have similar immunological responses to local strains of Vibrio anguillarum as those reported for the more genetically diverse populations of these fish and strains of V. anguillarum found in the Northern...

journal_title：Immunology and cell biology

authors： Munday BL,Carson J,Whittington R,Alexander J

更新日期：1992-12-01 00:00:00

abstract：:For the past 20 years footrot vaccines have evolved from simple bacterins to highly specific recombinant DNA (rDNA) fimbrial vaccines. The development of these vaccines has left a trail of discoveries, challenges and solutions; these processes continue as we move closer to understanding the requirements of a footrot v...

journal_title：Immunology and cell biology

authors： O'Meara TJ,Egerton JR,Raadsma HW

更新日期：1993-10-01 00:00:00

abstract：:The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...

journal_title：Immunology and cell biology

authors： Chandrashekar R,Rao UR,Subrahmanyam D

更新日期：1990-02-01 00:00:00

abstract：:Mast cells (MC) can undergo significant changes in number and phenotype; these alterations result in the differential expression of growth factors and cytokines. Kit ligand (KL; stem cell factor) is produced by mesenchymal cells, and in the liver by biliary epithelial cells. Recent studies suggest that KL, and its rec...

journal_title：Immunology and cell biology

authors： Zweifel M,Breu K,Matozan K,Renner E,Welle M,Schaffner T,Clavien PA

更新日期：2005-12-01 00:00:00

abstract：:The molecular interactions between the T-cell receptor (TCR) and peptide-MHC (pMHC) have been elucidated in recent years. Nevertheless, the fact that binding of only slightly different ligands by a TCR, or ligation of the same pMHC at different developmental stages of the T cell, can have opposing consequences, contin...

journal_title：Immunology and cell biology

authors： Regner M

更新日期：2001-04-01 00:00:00

abstract：:The differentiation of myeloid cells into macrophages and granulocytes is accompanied by marked changes in adhesive phenotype. Here we seek to understand the regulation of expression and functionality of the VLA-4 (alpha 4 beta 1), LPAM-1 (alpha 4 beta 7) and HML-1 (alpha E beta 7) integrins on monocytes/macrophages a...

journal_title：Immunology and cell biology

authors： Yang Y,Harrison JE,Print CG,Lehnert K,Sammar M,Lazarovits A,Krissansen GW

更新日期：1996-10-01 00:00:00

abstract：:Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct...

journal_title：Immunology and cell biology

authors： Ueno H,Schmitt N,Palucka AK,Banchereau J

更新日期：2010-05-01 00:00:00

abstract：:The ability to accurately quantitate and experimentally examine epigenetic modifications across the human genome has exploded in the past decade. This has given rise to a wealth of new information concerning the contributions of epigenetic regulatory networks to the pathogenesis of human disease. In particular, immuno...

journal_title：Immunology and cell biology

authors： MacDonald IA,Hathaway NA

更新日期：2015-03-01 00:00:00

abstract：:The identification of the genes that make up rearranged immunoglobulin genes is critical to many studies. For example, the enumeration of mutations in immunoglobulin genes is important for the prognosis of chronic lymphocytic leukemia, and this requires the accurate identification of the germline genes from which a pa...

journal_title：Immunology and cell biology

authors： Wang Y,Jackson KJ,Sewell WA,Collins AM

更新日期：2008-02-01 00:00:00

abstract：:There is an urgent need for new, powerful adjuvants suitable for use with sub-unit and peptide vaccines in humans. We have measured the humoral immune response in BALB/c mice to vaccine formulations using recombinant HBsAg antigens, and gamma inulin and alum adjuvants. Using Merck, Sharpe & Dohme (MSD) HBsAg at 10 mic...

journal_title：Immunology and cell biology

authors： Leslie DE,Nicholson S,Dimitrakakis M,Johnston N,Gust ID

更新日期：1990-04-01 00:00:00