Interaction of monocytoid cells with the mucosal addressin MAdCAM-1 via the integrins VLA-4 and LPAM-1.

Abstract:

:The differentiation of myeloid cells into macrophages and granulocytes is accompanied by marked changes in adhesive phenotype. Here we seek to understand the regulation of expression and functionality of the VLA-4 (alpha 4 beta 1), LPAM-1 (alpha 4 beta 7) and HML-1 (alpha E beta 7) integrins on monocytes/macrophages and granulocytes, given that these integrins including LFA-1 (alpha L beta 2) mediate the entry, retention and signalling events of pathogenic leucocytes within chronically inflamed tissues. Phorbol ester-induced monocytic differentiation of the promyelocyte cell line HL60 led to increases in the steady-state levels of beta 2 and beta 7 mRNA transcripts, requiring a period of 10 and 24 h, respectively, of de novo protein synthesis. There was a parallel de novo expression of LPAM-1 on the cell surface, despite the fact that alpha 4 mRNA transcripts were rapidly down-regulated. At 72 h, HML-1 was not coexpressed with LPAM-1 on HL60 cells, although it was weakly expressed on peripheral blood monocytes/macrophages after a prolonged period of in vitro culture. Retinoic acid-induced granulocytic differentiation of HL60 cells led to the appearance of low levels of LPAM-1 at the cell surface. LPAM-1 was not found expressed on peripheral blood neutrophils, raising the possibility that it is transiently expressed during granulocyte differentiation. In accord with the above findings, differentiated monocytes and HL60 cells bound to recombinant MAdCAM-1 in an alpha 4- and beta 7-integrin-dependent fashion, whereas a population of undifferentiated HL60 cells and Mn(+2)-activated monocytes bound in an alpha 4-integrin-dependent beta 7-integrin-independent manner via VLA-4 expressed abundantly at all stages of differentiation. Four h after attachment, some of these VLA-4+ LPAM-1- HL60 cells could be seen to start spreading. These finding suggest that MAdCAM-1 can bind to VLA-4 when LPAM-1 is absent, and thus has the potential to recruit both VLA-4-bearing monocytes and VLA-4+ LPAM-1+ macrophages into chronically inflamed tissues.

journal_name

Immunol Cell Biol

authors

Yang Y,Harrison JE,Print CG,Lehnert K,Sammar M,Lazarovits A,Krissansen GW

doi

10.1038/icb.1996.67

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

383-93

issue

5

eissn

0818-9641

issn

1440-1711

journal_volume

74

pub_type

杂志文章
  • Gαq controls rheumatoid arthritis via regulation of Th17 differentiation.

    abstract::Gαq, the α-subunit of Gq protein, is ubiquitously expressed in mammalian cells. It initially attracted attention for its physiological significance in cardiovascular system. In recent years, studies have also indicated the important roles of Gαq in regulating immunity, supplying us a new insight into the mechanism of ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2015.13

    authors: Liu Y,Wang D,Li F,Shi G

    更新日期:2015-08-01 00:00:00

  • Effects of IL-10- and FasL-overexpressing dendritic cells on liver transplantation tolerance in a heterotopic liver transplantation rat model.

    abstract::Acute rejection is the major determinant for the long-term survival of donor liver after liver transplantation (LT). The aim of this study was to examine the therapeutic potential of interleukin (IL)-10-FasL-overexpressing immature dendritic cells (imDCs) to induce local immunosuppression in liver grafts. imDCs derive...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.12252

    authors: Chen L,Zhang L,Zhu Z,He W,Gao L,Zhang W,Liu J,Huang A

    更新日期:2019-09-01 00:00:00

  • Expression of the T cell receptor delta-chain repertoire in mouse lymph node.

    abstract::Despite the potential for extensive diversity of gamma delta TCR, especially for delta-chains, expression of the gamma delta TCR repertoire in various mouse epithelial tissues is highly restricted. This implies that the recognition of antigen by gamma delta T cells may also be limited. To date, however, few studies ha...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1996.56

    authors: Olive C

    更新日期:1996-08-01 00:00:00

  • Elevated granzyme B+ B-cell level in SIV-infection correlate with viral load and low CD4 T-cell count.

    abstract::Granzyme B-expressing (GrB+) B cells are thought to contribute to immune dysfunctions in HIV patients, but so far their exact role is unknown. This report demonstrates for the first time the existence of GrB+ B cells in SIV-infected rhesus macaques, which represent the most commonly used nonhuman primate model for HIV...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2016.96

    authors: Kotb A,Klippert A,Daskalaki M,Sauermann U,Stahl-Hennig C,Neumann B

    更新日期:2017-03-01 00:00:00

  • Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16.

    abstract::Many specific antiviral and antitumour immune responses have been attributed to the protective effects of antigen-specific CD8+ cytotoxic T lymphocytes (CTL). Recognition of virus infected or tumour cells by CTL requires presentation of at least one peptide epitope from a virus or tumour-specific antigen by the releva...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1711.2003.01130.x

    authors: Khammanivong V,Liu XS,Liu WJ,Rodda SJ,Leggatt GR,Tindle RW,Frazer IH,Fernando GJ

    更新日期:2003-02-01 00:00:00

  • Plasmacytoid and conventional dendritic cells are early producers of IL-12 in Neospora caninum-infected mice.

    abstract::Neospora caninum is a coccidian parasite causative of clinical infections in a wide range of animal hosts. The maturation and activation of splenic conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were studied here in BALB/c mice challenged intraperitoneal with N. caninum tachyzoites. The nu...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2009.65

    authors: Teixeira L,Botelho AS,Mesquita SD,Correia A,Cerca F,Costa R,Sampaio P,Castro AG,Vilanova M

    更新日期:2010-01-01 00:00:00

  • How adaptive antibodies facilitate the evolution of natural antibodies.

    abstract::It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The ev...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.1996.50

    authors: Anderson RW

    更新日期:1996-06-01 00:00:00

  • Novel homozygous variants in the SERPING1 gene in two Turkish families with hereditary angioedema of recessive inheritance.

    abstract::Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.12362

    authors: Mete Gökmen N,Rodríguez-Alcalde C,Gülbahar O,Lopez-Trascasa M,Onay H,López-Lera A

    更新日期:2020-09-01 00:00:00

  • Immunological phenotype of the murine Lrba knockout.

    abstract::Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the pheno...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2017.52

    authors: Gámez-Díaz L,Neumann J,Jäger F,Proietti M,Felber F,Soulas-Sprauel P,Perruzza L,Grassi F,Kögl T,Aichele P,Kilimann M,Grimbacher B,Jung S

    更新日期:2017-10-01 00:00:00

  • Special feature for the Olympics: effects of exercise on the immune system. Overview: exercise immunology.

    abstract::The review articles in this special feature reflect the current status of knowledge in the field of exercise immunology, with a focus on how exercise affects the human immune system and the health implications for resistance to infections and neoplastic diseases. In an Olympic year, the emphasis of exercise immunology...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1711.2000.t01-13-.x

    authors: Gleeson M

    更新日期:2000-10-01 00:00:00

  • PD-L2+ wound zone macrophage-like cells display M1/M2-mixed activation and restrain the effector Th1 responses.

    abstract::Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized the programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, and investigated their influence on helper T (Th) cell responses. Although a...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.12310

    authors: Tavukcuoglu E,Horzum U,Yilmaz KB,Esendagli G

    更新日期:2020-02-01 00:00:00

  • Demystifying the development of dendritic cell subtypes, a little.

    abstract::The broadest definition of dendritic cells (DCs) is white blood cells that can take up antigen, process it and then present antigen-derived peptides to activate cognate naive T cells. Although this definition is by no means perfect, it is nevertheless now textbook. The source of frustration more recently has focused o...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.2008.28

    authors: Naik SH

    更新日期:2008-07-01 00:00:00

  • Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production.

    abstract::The cytokine Tumor Necrosis Factor Superfamily member 14, TNFSF14 (or LIGHT), is a controversial player in numerous diseases. We investigated the role of endogenously expressed TNFSF14 in diet-induced obesity in vivo. Firstly, we studied the effects of Tnfsf14 ablation on the development of obesity, glucose intoleranc...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.1002

    authors: Saunders BM,Rudnicka C,Filipovska A,Davies S,Ward N,Hricova J,Schlaich MP,Matthews VB

    更新日期:2018-01-01 00:00:00

  • 'Reverse gear' cellular movement mediated by chemokines.

    abstract::We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1711.2001.01015.x

    authors: Zlatopolskiy A,Laurence J

    更新日期:2001-08-01 00:00:00

  • Ficolin A derived from local macrophages and neutrophils protects against lipopolysaccharide-induced acute lung injury by activating complement.

    abstract::Ficolins are important and widely distributed pattern recognition molecules that can induce lectin complement pathway activation and initiate the innate immune response. Although ficolins can bind lipopolysaccharide (LPS) in vitro, the sources, dynamic changes and roles of local ficolins in LPS-induced pulmonary infla...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.12344

    authors: Wu X,Yao D,Bao L,Liu D,Xu X,An Y,Zhang X,Cao B

    更新日期:2020-08-01 00:00:00

  • Macrophage inflammatory protein-2 and vascular endothelial growth factor regulate corneal neovascularization induced by infection with Pseudomonas aeruginosa in mice.

    abstract::Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1711.2002.01094.x

    authors: Xue ML,Thakur A,Willcox M

    更新日期:2002-08-01 00:00:00

  • Atopy and the ectopic immune response.

    abstract::A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.1996.28

    authors: Aalberse RC

    更新日期:1996-04-01 00:00:00

  • Binding of Tamm-Horsfall protein to complement 1q and complement 1, including influence of hydrogen-ion concentration.

    abstract::The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1711.2002.01125.x

    authors: Rhodes DC

    更新日期:2002-12-01 00:00:00

  • Lymphopenic effects on mice of a component of ammonia caramel, 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI).

    abstract::A derivative of ammonia caramel colour (AC) is known to induce a selective lymphopenia in rats. Accordingly, the haematological effects were studied in mice of oral administration in drinking water of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), the component of AC responsible for lymphopenia. Initially five groups...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1988.51

    authors: Iscaro A,Mackay IR,O'Brien C

    更新日期:1988-10-01 00:00:00

  • Type I interferons in regulation of mucosal immunity.

    abstract::The mucosal system is the first line of defense against many pathogens. It is continuously exposed to dietary and microbial antigens, and thus the host must maintain a homeostatic environment between commensal microbiota and pathogenic infections. Following infections and inflammatory events, a rapid innate immune res...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.2012.13

    authors: Mangan NE,Fung KY

    更新日期:2012-05-01 00:00:00

  • Humoral immune responses in mice using gamma inulin preparations as adjuvants for hepatitis B vaccines.

    abstract::There is an urgent need for new, powerful adjuvants suitable for use with sub-unit and peptide vaccines in humans. We have measured the humoral immune response in BALB/c mice to vaccine formulations using recombinant HBsAg antigens, and gamma inulin and alum adjuvants. Using Merck, Sharpe & Dohme (MSD) HBsAg at 10 mic...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1990.15

    authors: Leslie DE,Nicholson S,Dimitrakakis M,Johnston N,Gust ID

    更新日期:1990-04-01 00:00:00

  • How the thymus shaped immunology and beyond.

    abstract::Barely 60 years ago, the thymus was considered to be a vestigial organ with no known function or just a graveyard for dying lymphocytes. Now, the thymus and its cells cover a vast area of immunology, genetics and epigenetics relating to medicine, including inflammation, infection, vaccination, dysbiosis, immunodeficie...

    journal_title:Immunology and cell biology

    pub_type: 传,历史文章,信件

    doi:10.1111/imcb.12220

    authors: Miller J

    更新日期:2019-03-01 00:00:00

  • Effects of biological drug adalimumab on tumour necrosis factor-alpha-converting enzyme activation.

    abstract::Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE) is a membrane-bound metalloprotease and disintegrin. It is produced by a number of host cells and is known to shed and release cell-bound cytokines, particularly members of the TNF family. No investigations into the regulation of this enzyme by autoanti...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2009.97

    authors: Lisi S,Sisto M

    更新日期:2010-03-01 00:00:00

  • The importance of co-stimulation in the orchestration of T helper cell differentiation.

    abstract::Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.2015.45

    authors: Coquet JM,Rausch L,Borst J

    更新日期:2015-10-01 00:00:00

  • Immune response to Acanthocheilonema viteae infection in multimammate rats (Mastomys natalensis).

    abstract::The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1990.3

    authors: Chandrashekar R,Rao UR,Subrahmanyam D

    更新日期:1990-02-01 00:00:00

  • mTORC1 signaling is crucial for regulatory T cells to suppress macrophage-mediated inflammatory response after acute myocardial infarction.

    abstract::Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 si...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2015.88

    authors: Yang K,Zhang Y,Xu C,Li X,Li D

    更新日期:2016-03-01 00:00:00

  • The unconventional expression of IL-15 and its role in NK cell homeostasis.

    abstract::Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effec...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.2014.1

    authors: Huntington ND

    更新日期:2014-03-01 00:00:00

  • Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages.

    abstract::It has been described that polymorphonuclear neutrophils (PMNs) enhance the replication of CC-chemokine receptor 5/macrophage-tropic (R5) HIV in cultures of monocyte-derived macrophages (MDMs). In this study, the inhibitory effect of glycyrrhizin (GL) on R5 HIV replication influenced by PMNs was investigated in MDM cu...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2009.40

    authors: Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F

    更新日期:2009-10-01 00:00:00

  • Depression of cell-mediated immunity in plasmacytoma-bearing mice.

    abstract::Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1991.3

    authors: Ruszala-Mallon V,Silva J,Lumanglas AL,Durr FE,Wang BS

    更新日期:1991-02-01 00:00:00

  • Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile.

    abstract::During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2010.22

    authors: Balboa L,Romero MM,Yokobori N,Schierloh P,Geffner L,Basile JI,Musella RM,Abbate E,de la Barrera S,Sasiain MC,Alemán M

    更新日期:2010-10-01 00:00:00