Abstract:
:Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14(+) dermal DCs, cytotoxic T-cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4(+) T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Ueno H,Schmitt N,Palucka AK,Banchereau Jdoi
10.1038/icb.2010.28subject
Has Abstractpub_date
2010-05-01 00:00:00pages
376-80issue
4eissn
0818-9641issn
1440-1711pii
icb201028journal_volume
88pub_type
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