Regulation of human Th9 differentiation by type I interferons and IL-21.

abstract：:The secreted hexameric form of the dengue virus (DENV) non-structural protein 1 (NS1) has recently been shown to elicit inflammatory cytokine release and disrupt endothelial cell monolayer integrity. This suggests that circulating NS1 contributes to the vascular leak that plays a major role in the pathology of dengue ...

journal_title：Immunology and cell biology

authors： Modhiran N,Watterson D,Blumenthal A,Baxter AG,Young PR,Stacey KJ

更新日期：2017-05-01 00:00:00

abstract：:Regulating the strength and class of an immune response requires lymphocytes to act as complex signal integrating "machines", taking information from multiple sources while making decisions that affect the final outcome. Describing and understanding the decision-making behaviour of lymphocytes within the context of th...

journal_title：Immunology and cell biology

authors： Hodgkin PD

更新日期：2007-06-01 00:00:00

abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

journal_title：Immunology and cell biology

authors： Sullivan M

更新日期：2009-07-01 00:00:00

abstract：:Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein-based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through...

journal_title：Immunology and cell biology

authors： Stewart TJ,Fernando GJ,Frazer IH,Leggatt GR

更新日期：2004-10-01 00:00:00

abstract：:The possible role and influence of tumour necrosis factor-alpha (TNF-alpha) in the human mixed lymphocyte culture (MLC) reaction was investigated. Polyclonal rabbit sera to recombinant human-TNF-alpha (rhTNF-alpha) consistently inhibited the MLC, and this could be reversed by simultaneous addition of rhTNF-alpha to th...

journal_title：Immunology and cell biology

authors： Matthews SJ,Sullivan JS

更新日期：1992-04-01 00:00:00

abstract：:Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to deat...

journal_title：Immunology and cell biology

authors： Vasilikos L,Spilgies LM,Knop J,Wong WW

更新日期：2017-02-01 00:00:00

abstract：:Elucidating pathways that regulate cytokine production in the context of autoimmune disease will likely lead to the development of novel therapeutics. Herein, we review data suggesting that microRNAs (miRs) represent one such level of regulatory activity, with particular emphasis on the pathogenesis of rheumatoid arth...

journal_title：Immunology and cell biology

authors： Baxter D,McInnes IB,Kurowska-Stolarska M

更新日期：2012-03-01 00:00:00

abstract：:CD8+ T lymphocytes are key effectors in the control of viral diseases and some tumours. In general, the majority of CD8+ T cells recognize a few immunodominant epitopes, but in some circumstances, subdominant specificities may be more relevant as targets for vaccines or immunotherapy. Epstein-Barr virus (EBV)-associat...

journal_title：Immunology and cell biology

authors： Moor RJ,Morrison LE,Moss DJ,Tscharke DC

更新日期：2007-10-01 00:00:00

abstract：:Thy-1 (CD90) expressed by mouse T cells is known to have signal transducing properties, but the ability of Thy-1 to enhance cytotoxic T lymphocyte (CTL) development is not well understood. Here we show that stimulation of mouse T cells with monoclonal antibodies (mAb) to CD3, CD28 and Thy-1 (clone G7), which were coim...

journal_title：Immunology and cell biology

authors： Haeryfar SM,Conrad DM,Musgrave B,Hoskin DW

更新日期：2005-08-01 00:00:00

abstract：:This report summarizes recent advances on host-pathogen interactions, innate and adaptive responses to infection, as well as novel strategies for the control of infectious diseases. ...

journal_title：Immunology and cell biology

authors： Hansen DS,Stewart CR,Jaworowski A,de-Koning Ward TF

更新日期：2012-09-01 00:00:00

abstract：:Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...

journal_title：Immunology and cell biology

authors： Taylor-Robinson AW

更新日期：1997-04-01 00:00:00

abstract：:Fluorescent dyes are increasingly being exploited to track lymphocyte migration and proliferation. The present paper reviews the properties and performance of some 14 different fluorescent dyes that have been used during the last 20 years to monitor lymphocyte migration. Of the 14 dyes discussed, two stand out as bein...

journal_title：Immunology and cell biology

authors： Parish CR

更新日期：1999-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), the β-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity. Among them, HCMV uses cellular captured genes encoding molecules capable of interfering with the original host function or of fulfilling new immunomodulatory tasks. Here, we report on UL7, ...

journal_title：Immunology and cell biology

authors： Engel P,Pérez-Carmona N,Albà MM,Robertson K,Ghazal P,Angulo A

更新日期：2011-10-01 00:00:00

abstract：:T-cell activation RhoGTPase-activating protein (TAGAP) is a GTPase-activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome-wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, includi...

journal_title：Immunology and cell biology

authors： Tamehiro N,Nishida K,Yanobu-Takanashi R,Goto M,Okamura T,Suzuki H

更新日期：2017-09-01 00:00:00

abstract：:Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentatio...

journal_title：Immunology and cell biology

authors： Hill AB

更新日期：1996-12-01 00:00:00

abstract：:γδ T cells producing interleukin-17A (γδT17) are thought to develop spontaneously in the thymus and to be maintained in the periphery. Previous studies suggested a role for T-helper 17 (Th17) cells in the maintenance of γδT17 via the expression of transforming growth factor-β1 (TGFβ1). However, we have previously foun...

journal_title：Immunology and cell biology

authors： Gupta PK,Wagner SR,Wu Q,Shilling RA

更新日期：2017-03-01 00:00:00

abstract：:The broadest definition of dendritic cells (DCs) is white blood cells that can take up antigen, process it and then present antigen-derived peptides to activate cognate naive T cells. Although this definition is by no means perfect, it is nevertheless now textbook. The source of frustration more recently has focused o...

journal_title：Immunology and cell biology

authors： Naik SH

更新日期：2008-07-01 00:00:00

abstract：:Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 si...

journal_title：Immunology and cell biology

authors： Yang K,Zhang Y,Xu C,Li X,Li D

更新日期：2016-03-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE) is a membrane-bound metalloprotease and disintegrin. It is produced by a number of host cells and is known to shed and release cell-bound cytokines, particularly members of the TNF family. No investigations into the regulation of this enzyme by autoanti...

journal_title：Immunology and cell biology

authors： Lisi S,Sisto M

更新日期：2010-03-01 00:00:00

abstract：:The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellul...

journal_title：Immunology and cell biology

authors： Zhan Y,Kong I,Chopin M,Macri C,Zhang JG,Xie J,Nutt SL,O'Keeffe M,Hawkins ED,Morand EF,Lew AM

更新日期：2020-03-01 00:00:00

abstract：:T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC ...

journal_title：Immunology and cell biology

authors： Zanker D,Quinn K,Waithman J,Lata R,Murphy R,La Gruta NL,Chen W

更新日期：2015-05-01 00:00:00

abstract：:Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...

journal_title：Immunology and cell biology

authors： Price P,Cheong KY,Boodhoo A,Witt CS,McCann V,Christiansen FT,Allcock RJ

更新日期：2001-12-01 00:00:00

abstract：:Previous data from this laboratory have shown that fluorescein-specific cytotoxic T cells derived from naive mice are capable of distinguishing between different isomeric forms of the fluorescein hapten, as well as between the iodoacetamido-, isothiocyanate- and dichlorotriazinyl amino-fluorescein derivatives. In this...

journal_title：Immunology and cell biology

authors： Hughes EA,Kinnel G,Wickerham C,Atkeson B,Owen JA

更新日期：1995-04-01 00:00:00

abstract：:S100A8 and S100A9 are myeloid cell-derived proteins that are elevated in several types of inflammatory lung disorders. Pro- and anti-inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function separately, likely through distinct receptors but a systematic compa...

journal_title：Immunology and cell biology

authors： Hiroshima Y,Hsu K,Tedla N,Wong SW,Chow S,Kawaguchi N,Geczy CL

更新日期：2017-05-01 00:00:00

abstract：:In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA sequencing, and the state-of-the-art cytometry by time of flight (CyTOF) mass cytometer have allowed a detailed analysis of the sub-composition of different organs from the bone marrow hematopoietic compartment to the brain. T...

journal_title：Immunology and cell biology

authors： Proserpio V,Lönnberg T

更新日期：2016-03-01 00:00:00

abstract：:One of the major limitations for cancer immunotherapy is related to the frequent existence of an intra-tumoral immunosuppressive environment, to which STAT3 (Signal transducer and activator of transcription-3) activation in tumor and dendritic cells (DCs) are believed to contribute. In this study, we tested the hypoth...

journal_title：Immunology and cell biology

authors： Molavi O,Ma Z,Hamdy S,Lai R,Lavasanifar A,Samuel J

更新日期：2008-08-01 00:00:00

abstract：:The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...

journal_title：Immunology and cell biology

authors： Deenick EK

更新日期：2020-07-01 00:00:00

abstract：:Infection of mice with the flaviviruses West Nile virus (WNV) and Murray Valley encephalitis (MVE) induces cytolytic T-cell responses which are highly cross-reactive on target cells infected with heterologous flaviviruses. Of C57BL/6 mice infected with low doses (10(2)-10(6) PFU) of either virus, 30-40% develop enceph...

journal_title：Immunology and cell biology

authors： Wang Y,Lobigs M,Lee E,Müllbacher A

更新日期：2004-04-01 00:00:00

abstract：:A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal di...

journal_title：Immunology and cell biology

authors： Ho ES,O'Neill HC

更新日期：1995-06-01 00:00:00

abstract：:By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

journal_title：Immunology and cell biology

authors： Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

更新日期：1993-08-01 00:00:00