Abstract:
:Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to death receptor induced cell death, such as with tumour necrosis factor (TNF). Mouse genetics shows that there is some functional redundancy and the use of SMs has allowed us to understand how changing the composition of proteins recruited to TNF receptor 1 on TNF ligation can alter protein complex formation and activation of apoptosis or necroptosis, particularly when caspases are inhibited. Determining when or how caspase inhibition occurs physiologically combined with the loss of IAPs will be the next challenge in understanding the ability of IAPs to prevent cell death and/or limit inflammation.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Vasilikos L,Spilgies LM,Knop J,Wong WWdoi
10.1038/icb.2016.118subject
Has Abstractpub_date
2017-02-01 00:00:00pages
160-165issue
2eissn
0818-9641issn
1440-1711pii
icb2016118journal_volume
95pub_type
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