Induction of interleukin-10 expression through Fcalpha receptor in human monocytes and monocyte-derived dendritic cells: role of p38 MAPKinase.

abstract：:This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-se...

journal_title：Immunology and cell biology

authors： Blanden RV

更新日期：1995-02-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) and its receptor c-Met signaling have been implicated in regulating various types of cells including epithelial cells. We have previously reported that c-Met is expressed by thymic epithelial cells (TECs), and that in vivo administration of hybrid cytokines containing IL-7 and the beta- ...

journal_title：Immunology and cell biology

authors： Su M,Hu R,Song Y,Liu Y,Lai L

更新日期：2018-02-01 00:00:00

abstract：:This paper reports the production and characterization of three monoclonal antibodies (mAb) recognizing ovine vascular cell adhesion molecule-1 (VCAM-1). The mAb were raised against sheep umbilical vein endothelial cells (ShUVEC) and flow cytometric analysis demonstrated that one mAb, QE4G9, was cross-reactive with hu...

journal_title：Immunology and cell biology

authors： Grooby WL,Krishnan R,Russ GR

更新日期：1997-12-01 00:00:00

abstract：:This paper reports the isolation and characterization of sheep umbilical vein endothelial cells (ShUVEC) and examines the kinetics of the expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In culture, the cells demonstrate the classical endothelial cell phenot...

journal_title：Immunology and cell biology

authors： Grooby WL,Krishnan R,Russ GR

更新日期：1997-02-01 00:00:00

abstract：:The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4). These three MS4A family members are expressed on the cell surface of specific leukocyte subsets and have been well characterized as having key roles in ...

journal_title：Immunology and cell biology

authors： Eon Kuek L,Leffler M,Mackay GA,Hulett MD

更新日期：2016-01-01 00:00:00

abstract：:Elucidating pathways that regulate cytokine production in the context of autoimmune disease will likely lead to the development of novel therapeutics. Herein, we review data suggesting that microRNAs (miRs) represent one such level of regulatory activity, with particular emphasis on the pathogenesis of rheumatoid arth...

journal_title：Immunology and cell biology

authors： Baxter D,McInnes IB,Kurowska-Stolarska M

更新日期：2012-03-01 00:00:00

abstract：:Granzyme B (GrB) plays a well-established intracellular role in cytotoxic lymphocyte (CL)-mediated killing of abnormal cells; however, emerging evidence suggests that it participates in extracellular matrix remodeling and target cell destruction through anoikis. As these processes require the release of GrB from the C...

journal_title：Immunology and cell biology

authors： Prakash MD,Bird CH,Bird PI

更新日期：2009-03-01 00:00:00

abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

journal_title：Immunology and cell biology

authors： Sullivan M

更新日期：2009-07-01 00:00:00

abstract：:The molecular interactions between the T-cell receptor (TCR) and peptide-MHC (pMHC) have been elucidated in recent years. Nevertheless, the fact that binding of only slightly different ligands by a TCR, or ligation of the same pMHC at different developmental stages of the T cell, can have opposing consequences, contin...

journal_title：Immunology and cell biology

authors： Regner M

更新日期：2001-04-01 00:00:00

abstract：:Almost all vaccinations today are delivered through parenteral routes. Mucosal vaccination offers several benefits over parenteral routes of vaccination, including ease of administration, the possibility of self-administration, elimination of the chance of injection with infected needles, and induction of mucosal as w...

journal_title：Immunology and cell biology

authors： Vajdy M,Srivastava I,Polo J,Donnelly J,O'Hagan D,Singh M

更新日期：2004-12-01 00:00:00

abstract：:S100A8 and S100A9 are myeloid cell-derived proteins that are elevated in several types of inflammatory lung disorders. Pro- and anti-inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function separately, likely through distinct receptors but a systematic compa...

journal_title：Immunology and cell biology

authors： Hiroshima Y,Hsu K,Tedla N,Wong SW,Chow S,Kawaguchi N,Geczy CL

更新日期：2017-05-01 00:00:00

abstract：:Granzyme B-expressing (GrB+) B cells are thought to contribute to immune dysfunctions in HIV patients, but so far their exact role is unknown. This report demonstrates for the first time the existence of GrB+ B cells in SIV-infected rhesus macaques, which represent the most commonly used nonhuman primate model for HIV...

journal_title：Immunology and cell biology

authors： Kotb A,Klippert A,Daskalaki M,Sauermann U,Stahl-Hennig C,Neumann B

更新日期：2017-03-01 00:00:00

abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

journal_title：Immunology and cell biology

authors： Ohki K,Amano F,Yamamoto S,Kohashi O

更新日期：1999-04-01 00:00:00

abstract：:Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistoch...

journal_title：Immunology and cell biology

authors： El-Nefiawy N,Abdel-Hakim K,Yamashita A,Kanayama N

更新日期：2002-10-01 00:00:00

abstract：:Fundamentally new approaches are required for the development of vaccines to pre-empt and protect against emerging and pandemic influenzas. Current strategies involve post-emergent homotypic vaccines that are modelled upon select circulating 'seasonal' influenzas, but cannot induce cross-strain protection against newl...

journal_title：Immunology and cell biology

authors： Lynch GW,Selleck P,Church WB,Sullivan JS

更新日期：2012-02-01 00:00:00

abstract：:Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...

journal_title：Immunology and cell biology

authors： Tarlinton D

更新日期：2020-07-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) and urokinase-type plasminogen activator (uPA) can contribute to the progression of chronic inflammatory diseases with possible involvement of macrophages. In this study, we investigated the role of both GM-CSF and uPA in Porphyromonas gingivalis-induced experi...

journal_title：Immunology and cell biology

authors： Lam RS,O'Brien-Simpson NM,Hamilton JA,Lenzo JC,Holden JA,Brammar GC,Orth RK,Tan Y,Walsh KA,Fleetwood AJ,Reynolds EC

更新日期：2015-09-01 00:00:00

abstract：:Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...

journal_title：Immunology and cell biology

authors： Gregory KJ,Morin SM,Kubosiak A,Ser-Dolansky J,Schalet BJ,Jerry DJ,Schneider SS

更新日期：2020-11-01 00:00:00

abstract：:Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...

journal_title：Immunology and cell biology

authors： Iba Y,Kurosawa Y

更新日期：1997-04-01 00:00:00

abstract：:Antibodies can have a protective but non-essential role in natural chlamydial infections dependent on antigen specificity and antibody isotype. IgG is the dominant antibody in both male and female reproductive tract mucosal secretions, and is bi-directionally trafficked across epithelia by the neonatal Fc receptor (Fc...

journal_title：Immunology and cell biology

authors： Armitage CW,O'Meara CP,Harvie MC,Timms P,Blumberg RS,Beagley KW

更新日期：2014-05-01 00:00:00

abstract：:Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase-deficient conditions. This alternative ...

journal_title：Immunology and cell biology

authors： Lalaoui N,Brumatti G

更新日期：2017-02-01 00:00:00

abstract：:There is a need for non-living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Here we describe our experience with lipophilic immune-stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A. When given orally, ISCOMs containin...

journal_title：Immunology and cell biology

authors： Smith RE,Donachie AM,Mowat AM

更新日期：1998-06-01 00:00:00

abstract：:The contributing role of circulating human dendritic cell (DC) populations and basophils in the presentation and augmentation of Th2 responses remains to be determined. The present study aimed at elucidating the functional role of CD1c(+) myeloid DCs (mDCs), CD123(+) plasmacytoid DCs (pDCs), monocyte-derived DCs and b...

journal_title：Immunology and cell biology

authors： Rydnert F,Lundberg K,Greiff L,Lindstedt M

更新日期：2014-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent cancers worldwide with rising mortality rates predicted in the coming decades. In light of this, there is a continued need for improvement in our understanding of CRC biology and the development of novel treatment options. Tumor-derived extracellular vesicles (tEVs)...

journal_title：Immunology and cell biology

authors： Manning S,Danielson KM

更新日期：2018-03-25 00:00:00

abstract：:Despite the potential for extensive diversity of gamma delta TCR, especially for delta-chains, expression of the gamma delta TCR repertoire in various mouse epithelial tissues is highly restricted. This implies that the recognition of antigen by gamma delta T cells may also be limited. To date, however, few studies ha...

journal_title：Immunology and cell biology

authors： Olive C

更新日期：1996-08-01 00:00:00

abstract：:In the developing forebrain, mounting evidence suggests that neural stem cell proliferation and differentiation is regulated by growth factors. In vitro in the presence of serum, stem cell proliferation is predominantly mediated by fibroblast growth factor-2 (FGF-2) whereas neuronal differentiation can be triggered by...

journal_title：Immunology and cell biology

authors： Bartlett PF,Brooker GJ,Faux CH,Dutton R,Murphy M,Turnley A,Kilpatrick TJ

更新日期：1998-10-01 00:00:00

abstract：:The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...

journal_title：Immunology and cell biology

authors： Chandrashekar R,Rao UR,Subrahmanyam D

更新日期：1990-02-01 00:00:00

abstract：:The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2002-12-01 00:00:00

abstract：:The recognition of T cell receptors (TCR) by purified major histocompatibility complex (MHC) class II-peptide complexes in the absence of costimulatory signals leads to the induction of T cell non-responsiveness or anergy. In a recent study using human T cell clones, it was observed that prolonged incubation of restin...

journal_title：Immunology and cell biology

authors： Arimilli S,Mumm JB,Nag B

更新日期：1996-02-01 00:00:00

abstract：:Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-reg...

journal_title：Immunology and cell biology

authors： Zhang H,Xiao Y,Zhu Z,Li B,Greene MI

更新日期：2012-01-01 00:00:00