Abstract:
:Fundamentally new approaches are required for the development of vaccines to pre-empt and protect against emerging and pandemic influenzas. Current strategies involve post-emergent homotypic vaccines that are modelled upon select circulating 'seasonal' influenzas, but cannot induce cross-strain protection against newly evolved or zoonotically introduced highly pathogenic influenza (HPI). Avian H5N1 and the less-lethal 2009 H1N1 and their reassortants loom as candidates to seed a future HPI pandemic. Therefore, more universal 'seasoned' vaccine approaches are urgently needed for heterotypic protection ahead of time. Pivotal to this is the need to understand mechanisms that can deliver broad strain protection. Heterotypic and heterosubtypic humoral immunities have largely been overlooked for influenza cross-protection, with most 'seasoned' vaccine efforts for humans focussed on heterotypic cellular immunity. However, 5 years ago we began to identify direct and indirect indicators of humoral-herd immunity to protein sites preserved among H1N1, H3N2 and H5N1 influenzas. Since then the evidence for cross-protective antibodies in humans has been accumulating. Now proposed is a rationale to stimulate and enhance pre-existing heterotypic humoral responses that, together with cell-mediated initiatives, will deliver pre-emptive and universal human protection against emerging epidemic and pandemic influenzas.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Lynch GW,Selleck P,Church WB,Sullivan JSdoi
10.1038/icb.2011.38subject
Has Abstractpub_date
2012-02-01 00:00:00pages
149-58issue
2eissn
0818-9641issn
1440-1711pii
icb201138journal_volume
90pub_type
杂志文章,评审abstract::The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2000.00883.x
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abstract::NKT cells are a minor subset of T cells that have important roles in controlling immune responses in disease states including cancer, autoimmunity and pathogenic infections. In contrast to conventional T cells, NKT cells express an invariant TCR and respond to glycolipids presented by CD1d. In this study, we sought to...
journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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abstract::Adult Nematospiroides dubius excretory-secretory (ES) products were collected from worms cultured in vitro, radiolabelled and separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE). The components were characterized and assessed for molecular weight (MW) after autoradiography and gel staining, for a...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 临床试验,杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1996.67
更新日期:1996-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2006.01434.x
更新日期:2006-08-01 00:00:00
abstract::The utility of T-cell receptor (TCR) transgenic mice in medical research has been considerable, with applications ranging from basic biology all the way to translational and clinical investigations. Crossing of TCR transgenic mice with either recombination-activating gene (RAG)-1 or RAG-2 knockouts is frequently used ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12033
更新日期:2018-07-01 00:00:00
abstract::There is little evidence that cutaneous dendritic cells (DC), including epidermal Langerhans cells (LC), can induce immunity to UV radiation (UVR)-induced skin tumours. Here, it is shown that cells within skin can induce protective antitumour immunity against a UVR-induced fibrosarcoma. Transplantation of the skin ove...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2001.00967.x
更新日期:2001-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2013.74
更新日期:2014-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1999-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2008.27
更新日期:2008-08-01 00:00:00
abstract::Chronic obstructive pulmonary disease is a highly prevalent, complex disease, usually caused by cigarette smoke. It causes serious morbidity and mortality and costs the global community billions of dollars per year. While chronic inflammation, extracellular matrix destruction and increased airway epithelial cell apopt...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2003.t01-1-01170.x
更新日期:2003-08-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2014.3
更新日期:2014-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2015.90
更新日期:2016-03-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.1996.50
更新日期:1996-06-01 00:00:00
abstract::Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12362
更新日期:2020-09-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
abstract::The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2004.01216.x
更新日期:2004-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1987.29
更新日期:1987-06-01 00:00:00
abstract::The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary r...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00