Abstract：
:NKT cells are a minor subset of T cells that have important roles in controlling immune responses in disease states including cancer, autoimmunity and pathogenic infections. In contrast to conventional T cells, NKT cells express an invariant TCR and respond to glycolipids presented by CD1d. In this study, we sought to investigate the role of NKT cells in regulating the response to infection with HSV-1, and the mechanism involved, in well-established mouse models. Previous studies of HSV-1 disease in mice have shown clear roles for CD4+ and CD8+ T cells. The role of NKT cells in the resolution of HSV-1 (KOS strain) infection was investigated through flank zosteriform or footpad infection in wild-type versus CD1d-deficient mice, by measurement of viral plaque-forming units at different sites after infection, lesion severity and HSV-1-specific T-cell responses. In contrast to a previous study using a more virulent strain of HSV-1 (SC16 strain), no differences were observed in disease magnitude or resolution, and furthermore, the T-cell response to HSV-1 (KOS strain) was unaltered in the absence of NKT cells. In conclusion, this study shows that NKT cells do not play a general role in controlling the resolution or severity of HSV-1 infection. Instead, the resolution or severity of the infection may depend on the HSV-1 strain under investigation.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Cornish AL,Keating R,Kyparissoudis K,Smyth MJ,Carbone FR,Godfrey DIdoi
10.1111/j.1440-1711.2005.01396.xsubject
Has Abstractpub_date
2006-02-01 00:00:00pages
13-9issue
1eissn
0818-9641issn
1440-1711pii
ICBjournal_volume
84pub_type
杂志文章abstract：:The antitumour efficacy of Ida-anti-Ly-2.1 immunoconjugate in combination with murine TNF-alpha (mTNF-alpha) has been evaluated in a disseminated murine thymic lymphoma model E3. This tumour model shows characteristics similar to lymphoma in humans with widely disseminated tumour in major organs. In vitro both idarubi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1997.39
更新日期：1997-06-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1993.47
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：1997-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1995.42
更新日期：1995-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2020-12-04 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1999.00831.x
更新日期：1999-08-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.9
更新日期：1993-04-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：2017-03-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1990.15
更新日期：1990-04-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1998.00731.x
更新日期：1998-04-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1998.00753.x
更新日期：1998-08-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：1996-06-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2014-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-06-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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更新日期：2018-10-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2000.00951.x
更新日期：2000-12-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：1996-04-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：1997-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 临床试验,杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：1996-10-01 00:00:00
