Abstract:
:A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; migratory lymphoid cells may occasionally react and start an inefficient immune response in sites not so destined. This is called an ectopic immune response. This response lacks the regulatory influences prevailing in the lymphoid organs, which results in approximately equal quantities of the various immunoglobulin isotypes, including IgE. The atopy gene(s) work by increasing the risk of such an ectopic immune response.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Aalberse RCdoi
10.1038/icb.1996.28subject
Has Abstractpub_date
1996-04-01 00:00:00pages
201-5issue
2eissn
0818-9641issn
1440-1711journal_volume
74pub_type
杂志文章,评审abstract::Interferon regulatory factor (IRF) family members impart cell-type specificity to toll-like receptor (TLR) signalling, and we recently identified a role for IRF6 in TLR2 signalling in epithelial cells. TLR3 has a well-characterized role in wound healing in the skin, and here, we examined TLR3-dependent IRF6 functions ...
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
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更新日期:2016-03-01 00:00:00