Multifaceted role of the ubiquitin ligase Itch in immune regulation.

abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

journal_title：Immunology and cell biology

authors： Fernando SL,Britton WJ

更新日期：2006-04-01 00:00:00

abstract：:A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

journal_title：Immunology and cell biology

authors： Aalberse RC

更新日期：1996-04-01 00:00:00

abstract：:Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...

journal_title：Immunology and cell biology

authors： Iba Y,Kurosawa Y

更新日期：1997-04-01 00:00:00

abstract：:Almost all vaccinations today are delivered through parenteral routes. Mucosal vaccination offers several benefits over parenteral routes of vaccination, including ease of administration, the possibility of self-administration, elimination of the chance of injection with infected needles, and induction of mucosal as w...

journal_title：Immunology and cell biology

authors： Vajdy M,Srivastava I,Polo J,Donnelly J,O'Hagan D,Singh M

更新日期：2004-12-01 00:00:00

abstract：:Natural killer (NK) cells are part of the first line defense against tumors, parasites and virus-infected cells. Therefore, factors that control NK-cell numbers and their function are important. CD27 is constitutively expressed on NK cells and its expression correlates with sequential phases in NK-cell development, di...

journal_title：Immunology and cell biology

authors： De Colvenaer V,Taveirne S,Delforche M,De Smedt M,Vandekerckhove B,Taghon T,Boon L,Plum J,Leclercq G

更新日期：2011-10-01 00:00:00

abstract：:Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown. Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression t...

journal_title：Immunology and cell biology

authors： Liston A,Siggs OM,Goodnow CC

更新日期：2007-06-01 00:00:00

abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...

journal_title：Immunology and cell biology

authors： Croker BA,Handman E,Hayball JD,Baldwin TM,Voigt V,Cluse LA,Yang FC,Williams DA,Roberts AW

更新日期：2002-06-01 00:00:00

abstract：:PVG rats are resistant to actively induced experimental autoimmune encephalomyelitis (EAE) and this appears to be directly related to high and sustained systemic levels of reactive nitrogen intermediates(RNI) following sensitization for EAE when compared to the highly susceptible Lewis rat. An apparent cellular basis ...

journal_title：Immunology and cell biology

authors： Staykova MA,Cowden W,Willenborg DO

更新日期：2002-04-01 00:00:00

abstract：:T lymphocytes are characterized by the use of structurally diverse TCR. The discovery of subsets of canonical T cells that have structurally homogeneous TCR presents an enigma: What antigens do these T cells recognize, and how does their antigen specificity relate to their functions? One subset of canonical T cells is...

journal_title：Immunology and cell biology

authors： Gumperz JE

更新日期：2004-06-01 00:00:00

abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...

journal_title：Immunology and cell biology

authors： Chin J,Turner B,Barchia I,Mullbacher A

更新日期：2000-02-01 00:00:00

abstract：:Activins and inhibins are members of the transforming growth factor-β superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation...

journal_title：Immunology and cell biology

authors： Aleman-Muench GR,Soldevila G

更新日期：2012-02-01 00:00:00

abstract：:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...

journal_title：Immunology and cell biology

authors： Saunders BM,Britton WJ

更新日期：2007-02-01 00:00:00

abstract：:Plasma cells play a pivotal role in the immune system and are responsible for the synthesis and release of immunoglobulins. Numerous in vitro culture experiments on the yolk sac demonstrated the generation of mature cells of the myeloid and lymphoid lineages under appropriate culture conditions. However, there are no ...

journal_title：Immunology and cell biology

authors： El-Nefiawy N,Abdel-Hakim K,Kanayama N,Suganuma N,Terao T

更新日期：2003-10-01 00:00:00

abstract：:The three modes of antibody production, natural, T independent (TI) and T dependent (TD) are conserved among vertebrate species suggesting an important role for each in protection against pathogens. Here, I use an artificial 'universe' to argue that the three modes of antibody production represent layers that evolved ...

journal_title：Immunology and cell biology

authors： Hodgkin PD

更新日期：1997-12-01 00:00:00

abstract：:Lipid rafts are small laterally mobile microdomains that are highly enriched in lymphocyte signaling molecules. GM1 gangliosides are a common lipid raft component and have been shown to be important in many T-cell functions. The aggregation of specific GM1 lipid rafts can control many T-cell activation events, includi...

journal_title：Immunology and cell biology

authors： Mitchell JS,Brown WS,Woodside DG,Vanderslice P,McIntyre BW

更新日期：2009-05-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

journal_title：Immunology and cell biology

authors： Xu Y,Hunt NH,Bao S

更新日期：2007-11-01 00:00:00

abstract：:Granzyme B (GrB) plays a well-established intracellular role in cytotoxic lymphocyte (CL)-mediated killing of abnormal cells; however, emerging evidence suggests that it participates in extracellular matrix remodeling and target cell destruction through anoikis. As these processes require the release of GrB from the C...

journal_title：Immunology and cell biology

authors： Prakash MD,Bird CH,Bird PI

更新日期：2009-03-01 00:00:00

abstract：:Interleukin (IL)-9-producing CD4(+) T cells are a novel subset of T helper (Th) cells that develops independently of the Th1, Th2, Th17 and regulatory T-cell lineages. Similar to the murine model, transforming growth factor (TGF)-beta and IL-4 directed human naive CD4(+) T cells to produce IL-9. Whereas IL-4 suppresse...

journal_title：Immunology and cell biology

authors： Wong MT,Ye JJ,Alonso MN,Landrigan A,Cheung RK,Engleman E,Utz PJ

更新日期：2010-08-01 00:00:00

abstract：:Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...

journal_title：Immunology and cell biology

authors： Marsland BJ,Camberis M,Le Gros G

更新日期：2005-02-01 00:00:00

abstract：:Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...

journal_title：Immunology and cell biology

authors： Price P,Cheong KY,Boodhoo A,Witt CS,McCann V,Christiansen FT,Allcock RJ

更新日期：2001-12-01 00:00:00

abstract：:Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. These proteins are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. Because differential splicing pro...

journal_title：Immunology and cell biology

authors： Rebollo A,Schmitt C

更新日期：2003-06-01 00:00:00

abstract：:Substance abuse is a growing world-wide problem. The big four drugs of abuse that might lend themselves to immunotherapy are nicotine, cocaine, morphine/heroin and methamphetamine. Tobacco abuse has a well-known enormous impact on major chronic cardiovascular and pulmonary diseases, while the last three, aside from th...

journal_title：Immunology and cell biology

authors： Kinsey BM,Jackson DC,Orson FM

更新日期：2009-05-01 00:00:00

abstract：:Intravenous (i.v.) immunization of mice with recombinant vaccinia viruses stimulated the highest antibody and cytotoxic T lymphocyte (CTL) responses when i.v., intraperitoneal (i.p.), intranasal (i.n.), footpad (f.p.) and tail scarification (t.s.) routes were compared. Intraperitoneal immunization of mice resulted in ...

journal_title：Immunology and cell biology

authors： Andrew ME,Coupar BE,Boyle DB

更新日期：1989-10-01 00:00:00

abstract：:The identification of the genes that make up rearranged immunoglobulin genes is critical to many studies. For example, the enumeration of mutations in immunoglobulin genes is important for the prognosis of chronic lymphocytic leukemia, and this requires the accurate identification of the germline genes from which a pa...

journal_title：Immunology and cell biology

authors： Wang Y,Jackson KJ,Sewell WA,Collins AM

更新日期：2008-02-01 00:00:00

abstract：:The contributing role of circulating human dendritic cell (DC) populations and basophils in the presentation and augmentation of Th2 responses remains to be determined. The present study aimed at elucidating the functional role of CD1c(+) myeloid DCs (mDCs), CD123(+) plasmacytoid DCs (pDCs), monocyte-derived DCs and b...

journal_title：Immunology and cell biology

authors： Rydnert F,Lundberg K,Greiff L,Lindstedt M

更新日期：2014-07-01 00:00:00

abstract：:We recently demonstrated that 17beta-estradiol (E2) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect of E2 on leishmanicidal activity and cytokine production by bone marrow-derived macrophages (BMDMs) f...

journal_title：Immunology and cell biology

authors： Lezama-Dávila CM,Isaac-Márquez AP,Barbi J,Cummings HE,Lu B,Satoskar AR

更新日期：2008-08-01 00:00:00

abstract：:Chronic obstructive pulmonary disease is a highly prevalent, complex disease, usually caused by cigarette smoke. It causes serious morbidity and mortality and costs the global community billions of dollars per year. While chronic inflammation, extracellular matrix destruction and increased airway epithelial cell apopt...

journal_title：Immunology and cell biology

authors： Hodge S,Hodge G,Scicchitano R,Reynolds PN,Holmes M

更新日期：2003-08-01 00:00:00

abstract：:The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellul...

journal_title：Immunology and cell biology

authors： Zhan Y,Kong I,Chopin M,Macri C,Zhang JG,Xie J,Nutt SL,O'Keeffe M,Hawkins ED,Morand EF,Lew AM

更新日期：2020-03-01 00:00:00

abstract：:This report summarizes recent advances on host-pathogen interactions, innate and adaptive responses to infection, as well as novel strategies for the control of infectious diseases. ...

journal_title：Immunology and cell biology

authors： Hansen DS,Stewart CR,Jaworowski A,de-Koning Ward TF

更新日期：2012-09-01 00:00:00

abstract：:Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macr...

journal_title：Immunology and cell biology

authors： Dubey A,Izakelian L,Ayaub EA,Ho L,Stephenson K,Wong S,Kwofie K,Austin RC,Botelho F,Ask K,Richards CD

更新日期：2018-03-01 00:00:00