Abstract:
:The contributing role of circulating human dendritic cell (DC) populations and basophils in the presentation and augmentation of Th2 responses remains to be determined. The present study aimed at elucidating the functional role of CD1c(+) myeloid DCs (mDCs), CD123(+) plasmacytoid DCs (pDCs), monocyte-derived DCs and basophils in allergen presentation and Th2 activation. By coculturing Phleum pratense (Phl p)-pulsed CD1c(+) mDCs, CD123(+) pDCs, monocyte-derived DCs and basophils with autologous CD4(+) effector memory T cells, we assessed T-cell proliferation as well as the frequency of interleukin-4- and interferon-γ-producing T cells. Interestingly, a Th2-stimulating ability was observed for Phl p-challenged CD1c(+) mDCs and monocyte-derived DCs, while CD123(+) pDCs and basophils did not affect the Th-balance. In addition, both Phl p-pulsed CD1c(+) mDCs and monocyte-derived DCs stimulated increased T-cell proliferation compared to basophils and CD123(+) pDCs. Together, these results point to a prominent role for circulating CD1c(+) mDCs in allergen presentation and augmentation of Th2 responses, making them promising therapeutic targets for Type I hypersensitivity reactions.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Rydnert F,Lundberg K,Greiff L,Lindstedt Mdoi
10.1038/icb.2014.23subject
Has Abstractpub_date
2014-07-01 00:00:00pages
557-60issue
6eissn
0818-9641issn
1440-1711pii
icb201423journal_volume
92pub_type
临床试验,杂志文章abstract::The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to autoantigens and local immunosuppressive milieu contribute to the testicular immune privilege. Testicular immunosuppression has been intensively studied, but information on...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2014.97
更新日期:2015-03-01 00:00:00
abstract::Lipid rafts are small laterally mobile microdomains that are highly enriched in lymphocyte signaling molecules. GM1 gangliosides are a common lipid raft component and have been shown to be important in many T-cell functions. The aggregation of specific GM1 lipid rafts can control many T-cell activation events, includi...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2008.103
更新日期:2009-05-01 00:00:00
abstract::A general criterion is formulated to decide if the recycling of B cells exists in germinal centre (GC) reactions. The criterion is independent of the selection and affinity maturation process and based solely on total centroblast population arguments. An experimental test is proposed to verify whether the criterion is...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2002.01052.x
更新日期:2002-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/sj.icb.7100144
更新日期:2008-02-01 00:00:00
abstract::The trace element zinc is essential for the survival and function of all cells. Zinc deficiency, whether nutritional or genetic, is fatal if left untreated. The effects of zinc deficiency are particularly obvious in the skin, seen as an erythematous rash, scaly plaques, and ulcers. Electron microscopy reveals degenera...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2005.01391.x
更新日期:2006-02-01 00:00:00
abstract::Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:1991-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.1993.53
更新日期:1993-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2002.01077.x
更新日期:2002-06-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1992.22
更新日期:1992-06-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2009.17
更新日期:2009-05-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1993.13
更新日期:1993-04-01 00:00:00
abstract::The present report provides the first extensive characterization of the OT-I TCR transgenic line, which produces MHC class I-restricted, ovalbumin-specific, CD8+ T cells (OT-I cells). These cells are shown to be positively selected in vivo in H-2b C57BL/6 mice and in bm5 mice, which express the Kbm5 mutant molecule. I...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2000.00889.x
更新日期:2000-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2010.28
更新日期:2010-05-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2009.21
更新日期:2009-07-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1711.1998.00768.x
更新日期:1998-10-01 00:00:00
abstract::Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistoch...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2002.01109.x
更新日期:2002-10-01 00:00:00
abstract::This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-se...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.1995.15
更新日期:1995-02-01 00:00:00
abstract::By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1993.39
更新日期:1993-08-01 00:00:00
abstract::Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2009.92
更新日期:2010-02-01 00:00:00
abstract::It is known today that the immune system is influenced by various types of psychological and physiological stressors, including physical activity. It is well known that physical activity can influence neuropeptide levels both in the central nervous system as well as in peripheral blood. The reported changes of immune ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1711.2000.t01-10-.x
更新日期:2000-10-01 00:00:00
abstract::Latex beads, 250 and 610 nm in diameter, and parapox virus isolated from ecthyma in sheep, were injected into intestinal loops containing either jejunal or ileal Peyer's patches (PP) of 3-4 week old calves. Uptake of latex and parapox virus was restricted to the ileal PP, 30-60 min after injection. The latex beads see...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1988.35
更新日期:1988-08-01 00:00:00
abstract::The Australian populations of rainbow trout (Onchorhynchus mykiss) and Atlantic salmon (Salmo salar) were found to have similar immunological responses to local strains of Vibrio anguillarum as those reported for the more genetically diverse populations of these fish and strains of V. anguillarum found in the Northern...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1992.51
更新日期:1992-12-01 00:00:00
abstract::The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4). These three MS4A family members are expressed on the cell surface of specific leukocyte subsets and have been well characterized as having key roles in ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2015.48
更新日期:2016-01-01 00:00:00
abstract::Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype ...
journal_title:Immunology and cell biology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/icb.2013.84
更新日期:2014-02-01 00:00:00
abstract::The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differen...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
abstract::Recombinant DNA techniques were used to clone, construct and express the bifunctional molecule FV/IL-2. The FV/IL-2 is a single-chain 37 kDa fusion protein expressed in Escherichia coli under control of the strong T7 bacteriophage promoter in the expression vector pT7-7-FV-IL-2. The fused gene fragment FV-IL-2 contain...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1994.42
更新日期:1994-08-01 00:00:00
abstract::Fluorescent dyes are increasingly being exploited to track lymphocyte migration and proliferation. The present paper reviews the properties and performance of some 14 different fluorescent dyes that have been used during the last 20 years to monitor lymphocyte migration. Of the 14 dyes discussed, two stand out as bein...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1999-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1988.39
更新日期:1988-08-01 00:00:00
abstract::The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of th...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.85
更新日期:2017-01-01 00:00:00
abstract::During an allergic inflammatory response in the airway, if a failure of the epithelial cell barrier occurs before the systemic immune response is triggered by allergens, more allergens can invade. Using a rat model of asthma, we previously found that mucosal mast cells, which localise to the epithelial layer of the ai...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2010.90
更新日期:2011-02-01 00:00:00