Abstract:
:Activins and inhibins are members of the transforming growth factor-β superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation of hematopoiesis in the bone marrow under homeostatic and inflammatory conditions. Recent data provide a more comprehensive understanding about the role of activins/inhibins in the immune system. Novel findings included in this review point out the important requirement of activin/inhibin signaling to maintain the balance between homeostatic and inflammatory signals that are required for the optimal development and function of immune cells. The purpose of this review is to highlight the versatile nature of activins/inhibins as key regulators of both the innate and adaptive immune responses.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Aleman-Muench GR,Soldevila Gdoi
10.1038/icb.2011.32subject
Has Abstractpub_date
2012-02-01 00:00:00pages
137-48issue
2eissn
0818-9641issn
1440-1711pii
icb201132journal_volume
90pub_type
杂志文章,评审abstract::Many specific antiviral and antitumour immune responses have been attributed to the protective effects of antigen-specific CD8+ cytotoxic T lymphocytes (CTL). Recognition of virus infected or tumour cells by CTL requires presentation of at least one peptide epitope from a virus or tumour-specific antigen by the releva...
journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
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更新日期:1999-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1993-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1996.56
更新日期:1996-08-01 00:00:00
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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