Importance of carbohydrate in the interaction of Tamm-Horsfall protein with complement 1q and inhibition of classical complement activation.

abstract：:By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

journal_title：Immunology and cell biology

authors： Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

更新日期：1993-08-01 00:00:00

abstract：:The NK gene complex (NKC) on mouse chromosome 6 encodes receptors that are expressed on NK cells, such as Ly49H, and is involved in regulating NK cell control of virus infections, such as murine cytomegalovirus (MCMV). In the present study, we investigated the level of allelic heterogeneity in NKC loci in populations ...

journal_title：Immunology and cell biology

authors： Scalzo AA,Manzur M,Forbes CA,Brown MG,Shellam GR

更新日期：2005-04-01 00:00:00

abstract：:Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...

journal_title：Immunology and cell biology

authors： Xue ML,Thakur A,Willcox M

更新日期：2002-08-01 00:00:00

abstract：:During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...

journal_title：Immunology and cell biology

authors： Balboa L,Romero MM,Yokobori N,Schierloh P,Geffner L,Basile JI,Musella RM,Abbate E,de la Barrera S,Sasiain MC,Alemán M

更新日期：2010-10-01 00:00:00

abstract：:NK cells from three donors with a NK (CD3- CD56+ CD16+) lymphocytosis of unknown aetiology showed differential expression of CD45R0, an isoform of CD45 not expressed by NK cells from normal donors unless stimulated to proliferate in vitro. For donor FC, 60% of NK cells expressed CD45R0 over a 16 month period during wh...

journal_title：Immunology and cell biology

authors： Warren HS,Kinnear BF,Skipsey LJ,Pembrey RG

更新日期：1994-12-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...

journal_title：Immunology and cell biology

authors： Abdel-Nour M,Tsalikis J,Kleinman D,Girardin SE

更新日期：2014-04-01 00:00:00

abstract：:zeta (CD3-zeta) and gamma (Fc epsilon RI gamma) chains associate with CD16, the low affinity receptor for IgG (Fc gamma RIII) on human NK cells and are essential for the cell surface expression of CD16 and for CD16-mediated effector functions. This study has investigated whether, on NK cells, molecules other than CD16...

journal_title：Immunology and cell biology

authors： Altin JG,Pagler EB,Kinnear BF,Warren HS

更新日期：1994-02-01 00:00:00

abstract：:There is little evidence that cutaneous dendritic cells (DC), including epidermal Langerhans cells (LC), can induce immunity to UV radiation (UVR)-induced skin tumours. Here, it is shown that cells within skin can induce protective antitumour immunity against a UVR-induced fibrosarcoma. Transplantation of the skin ove...

journal_title：Immunology and cell biology

authors： Sluyter R,Yuen KS,Halliday GM

更新日期：2001-02-01 00:00:00

abstract：:A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

journal_title：Immunology and cell biology

authors： Aalberse RC

更新日期：1996-04-01 00:00:00

abstract：:Natural suppressor (NS) cell line (Clone 59) was established from the bone marrow of adult C3H/Hej mice in the presence of WEHI-3 conditioned media. Clone 59 cells suppressed the generation of cytotoxic T lymphocytes from normal mouse spleen. This suppression was seen at a responder-to-suppressor cell ratio of 1000:1 ...

journal_title：Immunology and cell biology

authors： Yanagië H,Sugiyama H,Sekiguchi M

更新日期：1995-08-01 00:00:00

abstract：:Many specific antiviral and antitumour immune responses have been attributed to the protective effects of antigen-specific CD8+ cytotoxic T lymphocytes (CTL). Recognition of virus infected or tumour cells by CTL requires presentation of at least one peptide epitope from a virus or tumour-specific antigen by the releva...

journal_title：Immunology and cell biology

authors： Khammanivong V,Liu XS,Liu WJ,Rodda SJ,Leggatt GR,Tindle RW,Frazer IH,Fernando GJ

更新日期：2003-02-01 00:00:00

abstract：:CD4(+) T cells are activated upon recognition of peptide antigen in the context of MHC class II molecules, expressed by specialized APC. In this study, we show that CD4(+) T cells cross-compete for antigenic complexes on the surface of APC, inhibiting activation of other potentially reactive T cells of the same and di...

journal_title：Immunology and cell biology

authors： Hayball JD,Robinson BW,Lake RA

更新日期：2004-04-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

journal_title：Immunology and cell biology

authors： Simone LC,Wang X,Tuli A,Solheim JC

更新日期：2010-01-01 00:00:00

abstract：:The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...

journal_title：Immunology and cell biology

authors： Zanker D,Pang K,Oveissi S,Lu C,Faou P,Nowell C,Mbogo GW,Carotta S,Quillici C,Karupiah G,Hibbs ML,Nutt SL,Neeson P,Puthalakath H,Chen W

更新日期：2018-10-01 00:00:00

abstract：:The glycoprotein processing inhibitor castanospermine (CS) and the monosaccharide mannose-6-phosphate (M6P), as well as some sulfated polysaccharides (SPS), have been shown to inhibit inflammation in rat models of experimental autoimmune encephalomyelitis and adjuvant-induced arthritis. Here, the anti-inflammatory eff...

journal_title：Immunology and cell biology

authors： Bartlett MR,Warren HS,Cowden WB,Parish CR

更新日期：1994-10-01 00:00:00

abstract：:The broadest definition of dendritic cells (DCs) is white blood cells that can take up antigen, process it and then present antigen-derived peptides to activate cognate naive T cells. Although this definition is by no means perfect, it is nevertheless now textbook. The source of frustration more recently has focused o...

journal_title：Immunology and cell biology

authors： Naik SH

更新日期：2008-07-01 00:00:00

abstract：:Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...

journal_title：Immunology and cell biology

authors： Coquet JM,Rausch L,Borst J

更新日期：2015-10-01 00:00:00

abstract：:The ability of a tunicate immunomodulatory protein, tunIL1, to interact with mammalian cells was investigated. TunIL1 is known to regulate inflammatory defence reactions in tunicates and to stimulate the proliferation of mammalian thymocytes. In the current study, tunIL1 was shown to enchance L929 fibroblast prolifera...

journal_title：Immunology and cell biology

authors： Raftos D

更新日期：1996-02-01 00:00:00

abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

journal_title：Immunology and cell biology

authors： Chazaud B

更新日期：2016-02-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE) is a membrane-bound metalloprotease and disintegrin. It is produced by a number of host cells and is known to shed and release cell-bound cytokines, particularly members of the TNF family. No investigations into the regulation of this enzyme by autoanti...

journal_title：Immunology and cell biology

authors： Lisi S,Sisto M

更新日期：2010-03-01 00:00:00

abstract：:Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and ...

journal_title：Immunology and cell biology

authors： Henri S,Guilliams M,Poulin LF,Tamoutounour S,Ardouin L,Dalod M,Malissen B

更新日期：2010-05-01 00:00:00

abstract：:Productive immune responses to T-cell-dependent antigens ultimately generate two long-lived compartments: memory B cells and bone marrow-resident plasma cells, which both arise from within germinal centres. The ability of a B-cell clone to populate these effector compartments requires its descendents to outcompete tho...

journal_title：Immunology and cell biology

authors： Tarlinton DM

更新日期：2008-02-01 00:00:00

abstract：:The cytokine Tumor Necrosis Factor Superfamily member 14, TNFSF14 (or LIGHT), is a controversial player in numerous diseases. We investigated the role of endogenously expressed TNFSF14 in diet-induced obesity in vivo. Firstly, we studied the effects of Tnfsf14 ablation on the development of obesity, glucose intoleranc...

journal_title：Immunology and cell biology

authors： Saunders BM,Rudnicka C,Filipovska A,Davies S,Ward N,Hricova J,Schlaich MP,Matthews VB

更新日期：2018-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies ...

journal_title：Immunology and cell biology

authors： Shibata T,Ato M

更新日期：2017-11-01 00:00:00

abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...

journal_title：Immunology and cell biology

authors： Bretscher PA

更新日期：1992-10-01 00:00:00

abstract：:The expression of antigens in transgenic plants has been increasingly used in the development of experimental vaccines, particularly oriented to the development of edible vaccines. Hence, this technology becomes highly suitable to express immunogenic proteins from pathogens. Foot and mouth disease virus, bovine rotavi...

journal_title：Immunology and cell biology

authors： Dus Santos MJ,Wigdorovitz A

更新日期：2005-06-01 00:00:00

abstract：:Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...

journal_title：Immunology and cell biology

authors： Iba Y,Kurosawa Y

更新日期：1997-04-01 00:00:00

abstract：:Substance abuse is a growing world-wide problem. The big four drugs of abuse that might lend themselves to immunotherapy are nicotine, cocaine, morphine/heroin and methamphetamine. Tobacco abuse has a well-known enormous impact on major chronic cardiovascular and pulmonary diseases, while the last three, aside from th...

journal_title：Immunology and cell biology

authors： Kinsey BM,Jackson DC,Orson FM

更新日期：2009-05-01 00:00:00

abstract：:The contributing role of circulating human dendritic cell (DC) populations and basophils in the presentation and augmentation of Th2 responses remains to be determined. The present study aimed at elucidating the functional role of CD1c(+) myeloid DCs (mDCs), CD123(+) plasmacytoid DCs (pDCs), monocyte-derived DCs and b...

journal_title：Immunology and cell biology

authors： Rydnert F,Lundberg K,Greiff L,Lindstedt M

更新日期：2014-07-01 00:00:00

abstract：:T-cell activation RhoGTPase-activating protein (TAGAP) is a GTPase-activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome-wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, includi...

journal_title：Immunology and cell biology

authors： Tamehiro N,Nishida K,Yanobu-Takanashi R,Goto M,Okamura T,Suzuki H

更新日期：2017-09-01 00:00:00