Abstract:
:Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and the function of these five DC subsets before and after their migration to cutaneous draining lymph nodes. Moreover, it integrates this information into a unifying model that emphasizes the similarities that exist among the mouse DC subsets that are found in both lymphoid and nonlymphoid tissues.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Henri S,Guilliams M,Poulin LF,Tamoutounour S,Ardouin L,Dalod M,Malissen Bdoi
10.1038/icb.2010.34subject
Has Abstractpub_date
2010-05-01 00:00:00pages
366-75issue
4eissn
0818-9641issn
1440-1711pii
icb201034journal_volume
88pub_type
杂志文章,评审abstract::Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2015.97
更新日期:2016-02-01 00:00:00
abstract::The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-K...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2015.49
更新日期:2015-11-01 00:00:00
abstract::This study demonstrates that a syngeneic specific cytotoxic T lymphocyte (CTL) response to a class I major histocompatibility complex (MHC) positive tumour requires dual processing and recognition of tumour antigens. One type of antigen is processed and expressed in association with class I MHC at the surface of intac...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1993.36
更新日期:1993-08-01 00:00:00
abstract::Recombinant DNA techniques were used to clone, construct and express the bifunctional molecule FV/IL-2. The FV/IL-2 is a single-chain 37 kDa fusion protein expressed in Escherichia coli under control of the strong T7 bacteriophage promoter in the expression vector pT7-7-FV-IL-2. The fused gene fragment FV-IL-2 contain...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1994.42
更新日期:1994-08-01 00:00:00
abstract::Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12381
更新日期:2020-11-01 00:00:00
abstract::A murine monoclonal antibody has been used to characterise a 45,000 Da antigen that is associated with the surface membrane of merozoites of the human malaria parasite Plasmodium falciparum. The antigen is a glycoprotein and incorporates myristic acid. ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2001-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2011.59
更新日期:2012-04-01 00:00:00
abstract::Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2009.92
更新日期:2010-02-01 00:00:00
abstract::Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. These proteins are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. Because differential splicing pro...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1711.2003.01159.x
更新日期:2003-06-01 00:00:00
abstract::Plasma cells play a pivotal role in the immune system and are responsible for the synthesis and release of immunoglobulins. Numerous in vitro culture experiments on the yolk sac demonstrated the generation of mature cells of the myeloid and lymphoid lineages under appropriate culture conditions. However, there are no ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2003.t01-1-01178.x
更新日期:2003-10-01 00:00:00
abstract::The alpha-gal epitope (Galalpha1-3Galbeta1-(3)4GlcNAc-R) is abundantly synthesized on glycolipids and glycoproteins of non-primate mammals and New World monkeys by the glycosylation enzyme alpha1,3galactosyltransferase (alpha1,3GT). In humans, apes and Old World monkeys, this epitope is absent because the alpha1,3GT g...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1711.2005.01366.x
更新日期:2005-12-01 00:00:00
abstract::Thy-1 (CD90) expressed by mouse T cells is known to have signal transducing properties, but the ability of Thy-1 to enhance cytotoxic T lymphocyte (CTL) development is not well understood. Here we show that stimulation of mouse T cells with monoclonal antibodies (mAb) to CD3, CD28 and Thy-1 (clone G7), which were coim...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2005.01342.x
更新日期:2005-08-01 00:00:00
abstract::There is an urgent need for new, powerful adjuvants suitable for use with sub-unit and peptide vaccines in humans. We have measured the humoral immune response in BALB/c mice to vaccine formulations using recombinant HBsAg antigens, and gamma inulin and alum adjuvants. Using Merck, Sharpe & Dohme (MSD) HBsAg at 10 mic...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1990.15
更新日期:1990-04-01 00:00:00
abstract::The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...
journal_title:Immunology and cell biology
pub_type: 社论
doi:10.1111/imcb.12348
更新日期:2020-07-01 00:00:00
abstract::CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulat...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2012.71
更新日期:2013-02-01 00:00:00
abstract::Natural killer (NK) cells are part of the first line defense against tumors, parasites and virus-infected cells. Therefore, factors that control NK-cell numbers and their function are important. CD27 is constitutively expressed on NK cells and its expression correlates with sequential phases in NK-cell development, di...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2010.171
更新日期:2011-10-01 00:00:00
abstract::We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despi...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2001.01015.x
更新日期:2001-08-01 00:00:00
abstract::NK cells from three donors with a NK (CD3- CD56+ CD16+) lymphocytosis of unknown aetiology showed differential expression of CD45R0, an isoform of CD45 not expressed by NK cells from normal donors unless stimulated to proliferate in vitro. For donor FC, 60% of NK cells expressed CD45R0 over a 16 month period during wh...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1994.74
更新日期:1994-12-01 00:00:00
abstract::The CD46 lymphocyte surface antigen of man (until recently called HuLy-m5), and defined by the E4.3 monoclonal antibody (MoAb), shares cross-reactive antigenic epitopes with the envelope gp70 glycoproteins of gibbon ape leukaemia virus (GaLV) and Mason Pfizer monkey virus (MPMV) primate retroviruses. It is now shown t...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1989.42
更新日期:1989-10-01 00:00:00
abstract::Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2004.01303.x
更新日期:2005-02-01 00:00:00
abstract::Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/imcb.12346
更新日期:2020-07-01 00:00:00
abstract::Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
abstract::Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. A phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) mediates cluster formation of the host fungal receptors and enhances the phagocytosis and clearance of pathogenic fungi. Howe...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
abstract::Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immunoinhibi...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1993.13
更新日期:1993-04-01 00:00:00
abstract::The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4). These three MS4A family members are expressed on the cell surface of specific leukocyte subsets and have been well characterized as having key roles in ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract::The differentiation of myeloid cells into macrophages and granulocytes is accompanied by marked changes in adhesive phenotype. Here we seek to understand the regulation of expression and functionality of the VLA-4 (alpha 4 beta 1), LPAM-1 (alpha 4 beta 7) and HML-1 (alpha E beta 7) integrins on monocytes/macrophages a...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1996.67
更新日期:1996-10-01 00:00:00
abstract::The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
abstract::Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to deat...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00