Interactions of tunicate immunomodulatory proteins with mammalian cells.

abstract：:Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRR...

journal_title：Immunology and cell biology

authors： Yu L,Liu G,Yang C,Song X,Wang H

更新日期：2016-10-01 00:00:00

abstract：:Mice infected with Sarcocystis muris showed a significant reduction in plaque-forming cells (PFC) and delayed-type hypersensitivity (DHS) responses to an unrelated protein antigen, bovine gamma-globulin, when compared with uninfected controls. This immunosuppression was observed only when infection preceded immunizati...

journal_title：Immunology and cell biology

authors： Gill HS,Charleston WA,Moriarty KM

更新日期：1988-01-01 00:00:00

abstract：:Mucosal addressin cell adhesion molecule (MAdCAM-1) is a key player in mediating the infiltration of leucocytes into chronically inflamed tissues. Five anti-MAdCAM-1 monoclonal antibodies (mAb), designated 17F5, 201F7, 314G8, 377D10 and 355G8, were generated by fusion of P3 x 63Ag8.653 myeloma cells with spleen cells ...

journal_title：Immunology and cell biology

authors： Leung E,Lehnert KB,Kanwar JR,Yang Y,Mon Y,McNeil HP,Krissansen GW

更新日期：2004-08-01 00:00:00

abstract：:The CD46 lymphocyte surface antigen of man (until recently called HuLy-m5), and defined by the E4.3 monoclonal antibody (MoAb), shares cross-reactive antigenic epitopes with the envelope gp70 glycoproteins of gibbon ape leukaemia virus (GaLV) and Mason Pfizer monkey virus (MPMV) primate retroviruses. It is now shown t...

journal_title：Immunology and cell biology

authors： Purcell DF,Deacon NJ,McKenzie IF

更新日期：1989-10-01 00:00:00

abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

journal_title：Immunology and cell biology

authors： Lipoldová M,Holán V

更新日期：1991-12-01 00:00:00

abstract：:Thy-1 (CD90) expressed by mouse T cells is known to have signal transducing properties, but the ability of Thy-1 to enhance cytotoxic T lymphocyte (CTL) development is not well understood. Here we show that stimulation of mouse T cells with monoclonal antibodies (mAb) to CD3, CD28 and Thy-1 (clone G7), which were coim...

journal_title：Immunology and cell biology

authors： Haeryfar SM,Conrad DM,Musgrave B,Hoskin DW

更新日期：2005-08-01 00:00:00

abstract：:Peyer's patches (PP) are important inductive sites for the mucosal immune response. It is well known that lymphocytes that migrate into PP are mainly of T-cell lineage from thymus-derived cells (i.e. alphabetaTCR(high) cells). In this study, we further characterized the properties of PP lymphocytes in mice using a mou...

journal_title：Immunology and cell biology

authors： Takahashi S,Kawamura T,Kanda Y,Taniguchi T,Nishizawa T,Iiai T,Hatakeyama K,Abo T

更新日期：2005-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease is a highly prevalent, complex disease, usually caused by cigarette smoke. It causes serious morbidity and mortality and costs the global community billions of dollars per year. While chronic inflammation, extracellular matrix destruction and increased airway epithelial cell apopt...

journal_title：Immunology and cell biology

authors： Hodge S,Hodge G,Scicchitano R,Reynolds PN,Holmes M

更新日期：2003-08-01 00:00:00

abstract：:Listeria monocytogenes is the causative agent of infections like sepsis and meningitis, especially in immunocompromised hosts. Human macrophages are able to phagocytose and digest L. monocytogenes but IL-4 prevents human macrophages from killing the bacteria, the mechanisms of which are unknown. In the present study, ...

journal_title：Immunology and cell biology

authors： Neumann K,Eppler E,Filgueira L,Groscurth P,Gasal E,Schaffner A,Schoedon G,Schneemann M

更新日期：2003-12-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

journal_title：Immunology and cell biology

authors： Simone LC,Wang X,Tuli A,Solheim JC

更新日期：2010-01-01 00:00:00

abstract：:Mucosal mast cells (MMCs) have an important role in allergic inflammation, and effective antagonists are required for their regulation. To discover a possible mechanism of controlling the activation of MMCs, we investigated the expression and function of syntaxin4, one of the soluble membrane N-ethylmaleimide-sensitiv...

journal_title：Immunology and cell biology

authors： Liu S,Nugroho AE,Shudou M,Maeyama K

更新日期：2012-03-01 00:00:00

abstract：:CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in the bone marrow (BM). However, the molecular mechanisms of their establishment in the BM and their maintenance remain unclear. We here show that memory CD4 T cells express high levels of CD...

journal_title：Immunology and cell biology

authors： Hanazawa A,Hayashizaki K,Shinoda K,Yagita H,Okumura K,Löhning M,Hara T,Tani-ichi S,Ikuta K,Eckes B,Radbruch A,Tokoyoda K,Nakayama T

更新日期：2013-09-01 00:00:00

abstract：:Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...

journal_title：Immunology and cell biology

authors： Price P,Cheong KY,Boodhoo A,Witt CS,McCann V,Christiansen FT,Allcock RJ

更新日期：2001-12-01 00:00:00

abstract：:Latex beads, 250 and 610 nm in diameter, and parapox virus isolated from ecthyma in sheep, were injected into intestinal loops containing either jejunal or ileal Peyer's patches (PP) of 3-4 week old calves. Uptake of latex and parapox virus was restricted to the ileal PP, 30-60 min after injection. The latex beads see...

journal_title：Immunology and cell biology

authors： Landsverk T

更新日期：1988-08-01 00:00:00

abstract：:Asthma is a common and complex inflammatory disease of the airways that remains incurable. Current forms of therapy are long term and may exhibit associated side-effect problems. Major participants in the development of an asthma phenotype include the triggering stimuli such as the allergens themselves, cells such as ...

journal_title：Immunology and cell biology

authors： Ramshaw HS,Woodcock JM,Bagley CJ,McClure BJ,Hercus TR,Lopez AF

更新日期：2001-04-01 00:00:00

abstract：:Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistoch...

journal_title：Immunology and cell biology

authors： El-Nefiawy N,Abdel-Hakim K,Yamashita A,Kanayama N

更新日期：2002-10-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells are multipotent cells capable of differentiating into different mesodermal cell types. Enigmatically, mesenchymal stromal cells present in the bone marrow support early lymphopoiesis yet can inhibit mature lymphocyte growth. Critical features of the bone marrow microenvironment, s...

journal_title：Immunology and cell biology

authors： Prado-Lòpez S,Duffy MM,Baustian C,Alagesan S,Hanley SA,Stocca A,Griffin MD,Ceredig R

更新日期：2014-08-01 00:00:00

abstract：:CD8(+) T cells kill pancreatic β-cells in a cell-cell contact-dependent mechanism in the non-obese diabetic mouse. CD4(+) T lymphocytes are also able to kill pancreatic β-cells, but they do not directly contact β-cells and may use another cell type as the actual cytotoxic cell. Natural killer (NK) cells could have thi...

journal_title：Immunology and cell biology

authors： Angstetra E,Graham KL,Zhao Y,Irvin AE,Elkerbout L,Santamaria P,Slattery RM,Kay TW,Thomas HE

更新日期：2012-02-01 00:00:00

abstract：:Immunization of Lewis rats with guinea-pig myelin basic protein (Gp-MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encep...

journal_title：Immunology and cell biology

authors： Vandenbark AA,Chou YK,Whitham R,Bourdette DN,Offner H

更新日期：1998-02-01 00:00:00

abstract：:The present report provides the first extensive characterization of the OT-I TCR transgenic line, which produces MHC class I-restricted, ovalbumin-specific, CD8+ T cells (OT-I cells). These cells are shown to be positively selected in vivo in H-2b C57BL/6 mice and in bm5 mice, which express the Kbm5 mutant molecule. I...

journal_title：Immunology and cell biology

authors： Clarke SR,Barnden M,Kurts C,Carbone FR,Miller JF,Heath WR

更新日期：2000-04-01 00:00:00

abstract：:The alpha-gal epitope (Galalpha1-3Galbeta1-(3)4GlcNAc-R) is abundantly synthesized on glycolipids and glycoproteins of non-primate mammals and New World monkeys by the glycosylation enzyme alpha1,3galactosyltransferase (alpha1,3GT). In humans, apes and Old World monkeys, this epitope is absent because the alpha1,3GT g...

journal_title：Immunology and cell biology

authors： Galili U

更新日期：2005-12-01 00:00:00

abstract：:Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...

journal_title：Immunology and cell biology

authors： Logan GJ,Wang L,Zheng M,Coppel RL,Alexander IE

更新日期：2010-02-01 00:00:00

abstract：:Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing several inhibitors. A novel peroxidase detection system was used and te...

journal_title：Immunology and cell biology

authors： Shuler RL,Owen CS

更新日期：1993-02-01 00:00:00

abstract：:Ficolins are important and widely distributed pattern recognition molecules that can induce lectin complement pathway activation and initiate the innate immune response. Although ficolins can bind lipopolysaccharide (LPS) in vitro, the sources, dynamic changes and roles of local ficolins in LPS-induced pulmonary infla...

journal_title：Immunology and cell biology

authors： Wu X,Yao D,Bao L,Liu D,Xu X,An Y,Zhang X,Cao B

更新日期：2020-08-01 00:00:00

abstract：:We recently demonstrated that 17beta-estradiol (E2) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect of E2 on leishmanicidal activity and cytokine production by bone marrow-derived macrophages (BMDMs) f...

journal_title：Immunology and cell biology

authors： Lezama-Dávila CM,Isaac-Márquez AP,Barbi J,Cummings HE,Lu B,Satoskar AR

更新日期：2008-08-01 00:00:00

abstract：:Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...

journal_title：Immunology and cell biology

authors： Tarlinton D

更新日期：2020-07-01 00:00:00

abstract：:Deoxyspergualin (DOSP) is a new immunosuppressive agent which probably inhibits various functions of monocytes, B cells and T cells. We examined the effects of deoxyspergualin on cellular cytotoxicity, including cytotoxic T lymphocyte (CTL) mediated killer, natural killer (NK) cell and lymphokine activated killer (LAK...

journal_title：Immunology and cell biology

authors： Kerr PG,Atkins RC

更新日期：1991-06-01 00:00:00

abstract：:Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-reg...

journal_title：Immunology and cell biology

authors： Zhang H,Xiao Y,Zhu Z,Li B,Greene MI

更新日期：2012-01-01 00:00:00

abstract：:Almost all vaccinations today are delivered through parenteral routes. Mucosal vaccination offers several benefits over parenteral routes of vaccination, including ease of administration, the possibility of self-administration, elimination of the chance of injection with infected needles, and induction of mucosal as w...

journal_title：Immunology and cell biology

authors： Vajdy M,Srivastava I,Polo J,Donnelly J,O'Hagan D,Singh M

更新日期：2004-12-01 00:00:00

abstract：:Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...

journal_title：Immunology and cell biology

authors： Biswas R,Mukherjee S,Sinha D,Ghosh AK,Biswas T

更新日期：2014-04-01 00:00:00