解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In their recent publication, Kuczma and colleagues have provided evidence that advances the relationship between naive T cells, T cell anergy and T regulatory cells. Their findings strengthen the understanding of how these T cell subsets function in relation to self and microbiota-derived epitopes to promote and maint...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12424
更新日期:2020-12-04 00:00:00
abstract::Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12381
更新日期:2020-11-01 00:00:00
abstract::Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12362
更新日期:2020-09-01 00:00:00
abstract::Ficolins are important and widely distributed pattern recognition molecules that can induce lectin complement pathway activation and initiate the innate immune response. Although ficolins can bind lipopolysaccharide (LPS) in vitro, the sources, dynamic changes and roles of local ficolins in LPS-induced pulmonary infla...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12344
更新日期:2020-08-01 00:00:00
abstract::The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cance...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/imcb.12377
更新日期:2020-07-16 00:00:00
abstract::Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/imcb.12346
更新日期:2020-07-01 00:00:00
abstract::The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...
journal_title:Immunology and cell biology
pub_type: 社论
doi:10.1111/imcb.12348
更新日期:2020-07-01 00:00:00
abstract::The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellul...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12313
更新日期:2020-03-01 00:00:00
abstract::Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized the programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, and investigated their influence on helper T (Th) cell responses. Although a...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12310
更新日期:2020-02-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Studies in mice and humans have identified a role for microglial cells, th...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/imcb.12301
更新日期:2020-01-01 00:00:00
abstract::Endothelial cell (EC)-neutrophil (PMN) interactions are crucial in the resolution of bacterial infections. Prokaryotic RNA (pRNA) has been reported as a pathogen-associated molecular pattern that is released from bacteria upon death and is able to activate PMN. In this work, we studied the effects of pRNA on EC and in...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12282
更新日期:2019-10-01 00:00:00
abstract::Acute rejection is the major determinant for the long-term survival of donor liver after liver transplantation (LT). The aim of this study was to examine the therapeutic potential of interleukin (IL)-10-FasL-overexpressing immature dendritic cells (imDCs) to induce local immunosuppression in liver grafts. imDCs derive...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12252
更新日期:2019-09-01 00:00:00
abstract::Barely 60 years ago, the thymus was considered to be a vestigial organ with no known function or just a graveyard for dying lymphocytes. Now, the thymus and its cells cover a vast area of immunology, genetics and epigenetics relating to medicine, including inflammation, infection, vaccination, dysbiosis, immunodeficie...
journal_title:Immunology and cell biology
pub_type: 传,历史文章,信件
doi:10.1111/imcb.12220
更新日期:2019-03-01 00:00:00
abstract::The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12163
更新日期:2018-10-01 00:00:00
abstract::The utility of T-cell receptor (TCR) transgenic mice in medical research has been considerable, with applications ranging from basic biology all the way to translational and clinical investigations. Crossing of TCR transgenic mice with either recombination-activating gene (RAG)-1 or RAG-2 knockouts is frequently used ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12033
更新日期:2018-07-01 00:00:00
abstract::Sustained-release vaccine delivery systems may enhance the immunogenicity of subunit vaccines and reduce the need for multiple vaccinations. The aim of this study was to develop a thermoresponsive hydrogel using poloxamer 407-chitosan (CP) grafted copolymer as a delivery system for single-shot sustained-release vaccin...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12031
更新日期:2018-07-01 00:00:00
abstract::Within the immune system multiple mechanisms balance the need for efficient pathogen recognition and destruction with the prevention of tissue damage by excessive, inappropriate or even self-targeting (auto)immune reactions. This immune homeostasis is a tightly regulated system which fails during tumor development, of...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/imcb.12001
更新日期:2018-05-01 00:00:00
abstract::See also: Outstanding Observation by Wirasinha et al., Short Communication by Barnes & Cyster. ...
journal_title:Immunology and cell biology
pub_type: 评论,杂志文章
doi:10.1111/imcb.12027
更新日期:2018-04-01 00:00:00
abstract::Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. A phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) mediates cluster formation of the host fungal receptors and enhances the phagocytosis and clearance of pathogenic fungi. Howe...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12010
更新日期:2018-04-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the most prevalent cancers worldwide with rising mortality rates predicted in the coming decades. In light of this, there is a continued need for improvement in our understanding of CRC biology and the development of novel treatment options. Tumor-derived extracellular vesicles (tEVs)...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/imcb.12038
更新日期:2018-03-25 00:00:00
abstract::Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macr...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.1035
更新日期:2018-03-01 00:00:00
abstract::Interleukin (IL)-15 overexpression in eosinophilic gastrointestinal disorders is reported, but IL-15's role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte-overexpressed IL-15 transgenic mice using Fabpi promoter. The Fabpi-IL-15 (iIL-15) transgenic mice showed induced ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.1036
更新日期:2018-03-01 00:00:00
abstract::Hepatocyte growth factor (HGF) and its receptor c-Met signaling have been implicated in regulating various types of cells including epithelial cells. We have previously reported that c-Met is expressed by thymic epithelial cells (TECs), and that in vivo administration of hybrid cytokines containing IL-7 and the beta- ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.1026
更新日期:2018-02-01 00:00:00
abstract::The cytokine Tumor Necrosis Factor Superfamily member 14, TNFSF14 (or LIGHT), is a controversial player in numerous diseases. We investigated the role of endogenously expressed TNFSF14 in diet-induced obesity in vivo. Firstly, we studied the effects of Tnfsf14 ablation on the development of obesity, glucose intoleranc...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.1002
更新日期:2018-01-01 00:00:00
abstract::Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as w...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.63
更新日期:2017-11-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.61
更新日期:2017-11-01 00:00:00
abstract::The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary r...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.43
更新日期:2017-10-01 00:00:00
abstract::Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the pheno...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.52
更新日期:2017-10-01 00:00:00
abstract::Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.55
更新日期:2017-10-01 00:00:00
abstract::T-cell activation RhoGTPase-activating protein (TAGAP) is a GTPase-activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome-wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, includi...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.27
更新日期:2017-09-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is typically associated with extensive and progressive fibrosis, and is fatal and has limited treatment options. Characteristically IPF patients display large lymphocyte aggregates composed of CD3+ T cells and CD20+ B ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2017.22
更新日期:2017-08-01 00:00:00
abstract::The secreted hexameric form of the dengue virus (DENV) non-structural protein 1 (NS1) has recently been shown to elicit inflammatory cytokine release and disrupt endothelial cell monolayer integrity. This suggests that circulating NS1 contributes to the vascular leak that plays a major role in the pathology of dengue ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.5
更新日期:2017-05-01 00:00:00
abstract::S100A8 and S100A9 are myeloid cell-derived proteins that are elevated in several types of inflammatory lung disorders. Pro- and anti-inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function separately, likely through distinct receptors but a systematic compa...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.2
更新日期:2017-05-01 00:00:00
abstract::γδ T cells producing interleukin-17A (γδT17) are thought to develop spontaneously in the thymus and to be maintained in the periphery. Previous studies suggested a role for T-helper 17 (Th17) cells in the maintenance of γδT17 via the expression of transforming growth factor-β1 (TGFβ1). However, we have previously foun...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.94
更新日期:2017-03-01 00:00:00
abstract::Granzyme B-expressing (GrB+) B cells are thought to contribute to immune dysfunctions in HIV patients, but so far their exact role is unknown. This report demonstrates for the first time the existence of GrB+ B cells in SIV-infected rhesus macaques, which represent the most commonly used nonhuman primate model for HIV...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.96
更新日期:2017-03-01 00:00:00
abstract::Dendritic cells (DCs) are professional antigen-presenting cells that consist of functionally and phenotypically heterogeneous populations. Monocyte-derived DCs (moDCs) are a DC subset that have been attracting increasing interest owing to their potent influence on adaptive immune function and their rapid accumulation ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2016.104
更新日期:2017-03-01 00:00:00
abstract::Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to deat...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2016.118
更新日期:2017-02-01 00:00:00
abstract::Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase-deficient conditions. This alternative ...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2016.120
更新日期:2017-02-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease affecting predominantly motor neurons in the spinal cord and motor cortex. Neurodegeneration in ALS is accompanied by a well-characterized neuroinflammatory reaction within the central nervous system and, as described more recentl...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.89
更新日期:2017-02-01 00:00:00
abstract::The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of th...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.85
更新日期:2017-01-01 00:00:00