Culture-differentiated CD8(+) T cells acquire innate memory-like traits and respond to a pathogen-associated molecule.

abstract：:There is a need for non-living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Here we describe our experience with lipophilic immune-stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A. When given orally, ISCOMs containin...

journal_title：Immunology and cell biology

authors： Smith RE,Donachie AM,Mowat AM

更新日期：1998-06-01 00:00:00

abstract：:CD4(+) T cells are activated upon recognition of peptide antigen in the context of MHC class II molecules, expressed by specialized APC. In this study, we show that CD4(+) T cells cross-compete for antigenic complexes on the surface of APC, inhibiting activation of other potentially reactive T cells of the same and di...

journal_title：Immunology and cell biology

authors： Hayball JD,Robinson BW,Lake RA

更新日期：2004-04-01 00:00:00

abstract：:Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the m...

journal_title：Immunology and cell biology

authors： Miyara M,Sakaguchi S

更新日期：2011-03-01 00:00:00

abstract：:This paper reports the production and characterization of three monoclonal antibodies (mAb) recognizing ovine vascular cell adhesion molecule-1 (VCAM-1). The mAb were raised against sheep umbilical vein endothelial cells (ShUVEC) and flow cytometric analysis demonstrated that one mAb, QE4G9, was cross-reactive with hu...

journal_title：Immunology and cell biology

authors： Grooby WL,Krishnan R,Russ GR

更新日期：1997-12-01 00:00:00

abstract：:Interleukin (IL)-15 overexpression in eosinophilic gastrointestinal disorders is reported, but IL-15's role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte-overexpressed IL-15 transgenic mice using Fabpi promoter. The Fabpi-IL-15 (iIL-15) transgenic mice showed induced ...

journal_title：Immunology and cell biology

authors： Mussarat A,Manohar M,Verma AK,Upparahalli Venkateshaiah S,Zaidi A,Sanders NL,Zhu X,Mishra A

更新日期：2018-03-01 00:00:00

abstract：:The mucosal system is the first line of defense against many pathogens. It is continuously exposed to dietary and microbial antigens, and thus the host must maintain a homeostatic environment between commensal microbiota and pathogenic infections. Following infections and inflammatory events, a rapid innate immune res...

journal_title：Immunology and cell biology

authors： Mangan NE,Fung KY

更新日期：2012-05-01 00:00:00

abstract：:The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2002-12-01 00:00:00

abstract：:NK cell activity has been detected in the early murine decidua, and hypothesized to be mediated by granulated metrial gland (GMG) cells. The possibility that natural cytotoxic (NC) cells are also present in the decidua has not been investigated. In this study mAb to NK cells (anti-NK-1.1) and NC cells (anti-NC-1.1) we...

journal_title：Immunology and cell biology

authors： Clarke GR,Roberts TK,Smart YC

更新日期：1994-04-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

journal_title：Immunology and cell biology

authors： Xu Y,Hunt NH,Bao S

更新日期：2007-11-01 00:00:00

abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...

journal_title：Immunology and cell biology

authors： Croker BA,Handman E,Hayball JD,Baldwin TM,Voigt V,Cluse LA,Yang FC,Williams DA,Roberts AW

更新日期：2002-06-01 00:00:00

abstract：:We recently demonstrated that 17beta-estradiol (E2) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect of E2 on leishmanicidal activity and cytokine production by bone marrow-derived macrophages (BMDMs) f...

journal_title：Immunology and cell biology

authors： Lezama-Dávila CM,Isaac-Márquez AP,Barbi J,Cummings HE,Lu B,Satoskar AR

更新日期：2008-08-01 00:00:00

abstract：:Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...

journal_title：Immunology and cell biology

authors： Ruszala-Mallon V,Silva J,Lumanglas AL,Durr FE,Wang BS

更新日期：1991-02-01 00:00:00

abstract：:This study investigated the role of gamma delta T cells in experimental allergic encephalomyelitis (EAE), a chronic inflammatory disease of the central nervous system (CNS) that resembles multiple sclerosis. The strategy was to assess the effect on EAE of TCR peptide immunization directed against V gamma 6 T cells, sh...

journal_title：Immunology and cell biology

authors： Olive C

更新日期：1997-02-01 00:00:00

abstract：:We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despi...

journal_title：Immunology and cell biology

authors： Zlatopolskiy A,Laurence J

更新日期：2001-08-01 00:00:00

abstract：:NK cells from three donors with a NK (CD3- CD56+ CD16+) lymphocytosis of unknown aetiology showed differential expression of CD45R0, an isoform of CD45 not expressed by NK cells from normal donors unless stimulated to proliferate in vitro. For donor FC, 60% of NK cells expressed CD45R0 over a 16 month period during wh...

journal_title：Immunology and cell biology

authors： Warren HS,Kinnear BF,Skipsey LJ,Pembrey RG

更新日期：1994-12-01 00:00:00

abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

journal_title：Immunology and cell biology

authors： Wagle MV,Parish IA

更新日期：2016-10-01 00:00:00

abstract：:The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cance...

journal_title：Immunology and cell biology

authors： Watkins TS,Miles JJ

更新日期：2020-07-16 00:00:00

abstract：:Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Intera...

journal_title：Immunology and cell biology

authors： McCoy KD,Le Gros G

更新日期：1999-02-01 00:00:00

abstract：:Tamm-Horsfall protein (THP) binds strongly to complement 1q (C1q), a key component of the classical complement pathway. The goals of this study were to determine whether THP altered the activation of the classical complement pathway and whether the carbohydrate portion of THP was involved in this glycoprotein's bindin...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2006-08-01 00:00:00

abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...

journal_title：Immunology and cell biology

authors： Chin J,Turner B,Barchia I,Mullbacher A

更新日期：2000-02-01 00:00:00

abstract：:Concanavalin A (Con A)-induced hepatitis is thought to be a T-cell-mediated disease with active destruction of liver cells. Interleukin (IL)-17 is a cytokine produced principally by CD4(+) T cells. However, whether IL-17/IL-17 receptor (IL-17/IL-17R)-mediated responses are involved in T-cell-mediated Con A-induced liv...

journal_title：Immunology and cell biology

authors： Yan S,Wang L,Liu N,Wang Y,Chu Y

更新日期：2012-04-01 00:00:00

abstract：:Adult Nematospiroides dubius excretory-secretory (ES) products were collected from worms cultured in vitro, radiolabelled and separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE). The components were characterized and assessed for molecular weight (MW) after autoradiography and gel staining, for a...

journal_title：Immunology and cell biology

authors： Monroy FG,Adams JH,East IJ,Dobson C

更新日期：1989-04-01 00:00:00

abstract：:The ability of a tunicate immunomodulatory protein, tunIL1, to interact with mammalian cells was investigated. TunIL1 is known to regulate inflammatory defence reactions in tunicates and to stimulate the proliferation of mammalian thymocytes. In the current study, tunIL1 was shown to enchance L929 fibroblast prolifera...

journal_title：Immunology and cell biology

authors： Raftos D

更新日期：1996-02-01 00:00:00

abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

journal_title：Immunology and cell biology

authors： Chazaud B

更新日期：2016-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease is a highly prevalent, complex disease, usually caused by cigarette smoke. It causes serious morbidity and mortality and costs the global community billions of dollars per year. While chronic inflammation, extracellular matrix destruction and increased airway epithelial cell apopt...

journal_title：Immunology and cell biology

authors： Hodge S,Hodge G,Scicchitano R,Reynolds PN,Holmes M

更新日期：2003-08-01 00:00:00

abstract：:A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

journal_title：Immunology and cell biology

authors： Aalberse RC

更新日期：1996-04-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is related to dysfunction of intestinal immunity. Neutrophils have an important role in innate immunity via the oxidative burst, using the p47phox- and gp91(phox)-containing NAD(P)H oxidase known as Nox2. In dextran sulphate sodium (DSS)-induced colitis, no significant difference in in...

journal_title：Immunology and cell biology

authors： Bao S,Carr ED,Xu YH,Hunt NH

更新日期：2011-11-01 00:00:00

abstract：:Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...

journal_title：Immunology and cell biology

authors： Logan GJ,Wang L,Zheng M,Coppel RL,Alexander IE

更新日期：2010-02-01 00:00:00

abstract：:The CD46 lymphocyte surface antigen of man (until recently called HuLy-m5), and defined by the E4.3 monoclonal antibody (MoAb), shares cross-reactive antigenic epitopes with the envelope gp70 glycoproteins of gibbon ape leukaemia virus (GaLV) and Mason Pfizer monkey virus (MPMV) primate retroviruses. It is now shown t...

journal_title：Immunology and cell biology

authors： Purcell DF,Deacon NJ,McKenzie IF

更新日期：1989-10-01 00:00:00

abstract：:Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...

journal_title：Immunology and cell biology

authors： Coquet JM,Rausch L,Borst J

更新日期：2015-10-01 00:00:00