Abstract:
:NK cell activity has been detected in the early murine decidua, and hypothesized to be mediated by granulated metrial gland (GMG) cells. The possibility that natural cytotoxic (NC) cells are also present in the decidua has not been investigated. In this study mAb to NK cells (anti-NK-1.1) and NC cells (anti-NC-1.1) were used to characterize the decidual cells of days 8-14 pregnant (CBA x C57BL/6) F1 mice. Flow cytometric and immunohistological analyses showed predominantly NK-1.1+ and NC-1.1+ large and granular single nucleated decidual cells with abundant cytoplasm. A 'bright' and a 'dim' subset were identified for both NK-1.1+ and NC-1.1+ cells. The NC-1.1dim and NK-1.1dim cells increased in number and size as pregnancy progressed. When tested in 51Cr-release assays, the decidual cells showed significant levels of both NK and NC activities which increased with progression of pregnancy. The NK and NC activities were partially inhibited (47 and 34%) by preincubation of the decidual cells with anti-NC-1.1 and complement (C'), or anti-NC-1.1 alone. Results indicate that natural cell-mediated cytotoxicity in the decidua is in part, at least, mediated by NK-1.1+ and NC-1.1+ cells, and that the NK-1.1dim and NC-1.1dim cells are very likely to be GMG cells. This is the first report of NC cells in the mouse uterus.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Clarke GR,Roberts TK,Smart YCdoi
10.1038/icb.1994.23subject
Has Abstractpub_date
1994-04-01 00:00:00pages
153-60issue
2eissn
0818-9641issn
1440-1711journal_volume
72pub_type
杂志文章abstract::The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2002.01077.x
更新日期:2002-06-01 00:00:00
abstract::The three modes of antibody production, natural, T independent (TI) and T dependent (TD) are conserved among vertebrate species suggesting an important role for each in protection against pathogens. Here, I use an artificial 'universe' to argue that the three modes of antibody production represent layers that evolved ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1997.95
更新日期:1997-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.1995.79
更新日期:1995-12-01 00:00:00
abstract::FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that express...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1993.56
更新日期:1993-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2003.t01-1-01178.x
更新日期:2003-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2002.01052.x
更新日期:2002-02-01 00:00:00
abstract::Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1997.23
更新日期:1997-04-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2004.01303.x
更新日期:2005-02-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 临床试验,杂志文章
doi:10.1038/icb.2014.23
更新日期:2014-07-01 00:00:00
abstract::Rats primed with bovine myelin (BM) in complete Freunds adjuvant, develop acute experimental autoimmune encephalomyelitis (EAE). We have previously described that intraperitoneal administration prior to the active induction of the disease of a bovine synaptosomal fraction (BSF) and BM were effective ways of suppressin...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2004.01200.x
更新日期:2004-02-01 00:00:00
abstract::The Kunjin replicon was used to express a polytope that consisted of seven hepatitis C virus cytotoxic T lymphocyte epitopes and one influenza cytotoxic T lymphocyte epitope for vaccination studies. The self-replicating nature of, and expression from, the ribonucleic acid was confirmed in vitro. Initial vaccinations w...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.0818-9641.2002.01137.x
更新日期:2003-02-01 00:00:00
abstract::Intravenous (i.v.) immunization of mice with recombinant vaccinia viruses stimulated the highest antibody and cytotoxic T lymphocyte (CTL) responses when i.v., intraperitoneal (i.p.), intranasal (i.n.), footpad (f.p.) and tail scarification (t.s.) routes were compared. Intraperitoneal immunization of mice resulted in ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1989.48
更新日期:1989-10-01 00:00:00
abstract::Non-toxic agents that target intracellular signalling pathways in apoptosis may have potential therapeutic use in many diseases. One such agent is the transition metal Zn, a dietary cytoprotectant and anti-oxidant, which stimulates cell proliferation and suppresses apoptosis. Zn is maintained in discrete subcellular p...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1711.1999.00825.x
更新日期:1999-06-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1992.15
更新日期:1992-04-01 00:00:00
abstract::Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as w...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.63
更新日期:2017-11-01 00:00:00
abstract::Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRR...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.57
更新日期:2016-10-01 00:00:00
abstract::Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the pheno...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2017.52
更新日期:2017-10-01 00:00:00
abstract::Dendritic cell (DC)-based immunotherapy has recently demonstrated a great potential for clinical applications; however, additional progress in the methods of tumor-specific antigen delivery to DCs is necessary for the further development of anti-tumor vaccines. To this end, a capsid-optimized adeno-associated virus se...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2013.74
更新日期:2014-02-01 00:00:00
abstract::Mycobacterium tuberculosis uses numerous mechanisms to avoid elimination by the infected host. In this study, we investigated the possibility whether, similar to other pathogens, M. tuberculosis exploits natural CD4+ CD25+ T-regulatory cells (Treg) to suppress the effector function of responding host lymphocytes, thus...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2006.01460.x
更新日期:2006-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1711.2004.01288.x
更新日期:2004-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2010.34
更新日期:2010-05-01 00:00:00
abstract::Retinoic acid (RA) in the steady state enhances induction of Foxp3(+) regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby maintaining tolerance, but can in inflammatory conditions promote effector Th1 and Th17 cells that mediate inflammation. IL-17-producing γδ T cells have recently b...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.39
更新日期:2016-09-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1991.59
更新日期:1991-12-01 00:00:00
abstract::The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...
journal_title:Immunology and cell biology
pub_type: 社论
doi:10.1111/imcb.12348
更新日期:2020-07-01 00:00:00
abstract::Respiratory syncytial virus causes lower respiratory tract infections in infancy and old age, affecting also immunocompromised patients. The viral fusion protein is an important vaccine candidate eliciting antibody and cell-mediated immune responses. CD8(+) cytotoxic T lymphocytes (CTLs) are known to have a role in bo...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2012.43
更新日期:2012-11-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/sj.icb.7100148
更新日期:2008-02-01 00:00:00
abstract::Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...
journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
abstract::Recombinant DNA techniques were used to clone, construct and express the bifunctional molecule FV/IL-2. The FV/IL-2 is a single-chain 37 kDa fusion protein expressed in Escherichia coli under control of the strong T7 bacteriophage promoter in the expression vector pT7-7-FV-IL-2. The fused gene fragment FV-IL-2 contain...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1994.42
更新日期:1994-08-01 00:00:00