Single-chain antibody variable region-targeted interleukin-2 stimulates T cell killing of human colorectal carcinoma cells.

abstract：:Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized the programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, and investigated their influence on helper T (Th) cell responses. Although a...

journal_title：Immunology and cell biology

authors： Tavukcuoglu E,Horzum U,Yilmaz KB,Esendagli G

更新日期：2020-02-01 00:00:00

abstract：:The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2002-12-01 00:00:00

abstract：:NKT cells are a minor subset of T cells that have important roles in controlling immune responses in disease states including cancer, autoimmunity and pathogenic infections. In contrast to conventional T cells, NKT cells express an invariant TCR and respond to glycolipids presented by CD1d. In this study, we sought to...

journal_title：Immunology and cell biology

authors： Cornish AL,Keating R,Kyparissoudis K,Smyth MJ,Carbone FR,Godfrey DI

更新日期：2006-02-01 00:00:00

abstract：:The ability of a tunicate immunomodulatory protein, tunIL1, to interact with mammalian cells was investigated. TunIL1 is known to regulate inflammatory defence reactions in tunicates and to stimulate the proliferation of mammalian thymocytes. In the current study, tunIL1 was shown to enchance L929 fibroblast prolifera...

journal_title：Immunology and cell biology

authors： Raftos D

更新日期：1996-02-01 00:00:00

abstract：:Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Intera...

journal_title：Immunology and cell biology

authors： McCoy KD,Le Gros G

更新日期：1999-02-01 00:00:00

abstract：:Tumour cell heterogeneity is probably a principal cause of treatment failure and represents a formidable barrier for effective antibody-targeted chemotherapy. Idarubicin (Ida), a more potent and less cardiotoxic analogue of daunomycin, has been demonstrated to specifically target and eradicate homogeneous, cloned, mur...

journal_title：Immunology and cell biology

authors： Smyth MJ,Foster HM,Andrew SM,Teh JG,Krauer K,McKenzie IF,Pietersz GA

更新日期：1993-06-01 00:00:00

abstract：:Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct...

journal_title：Immunology and cell biology

authors： Ueno H,Schmitt N,Palucka AK,Banchereau J

更新日期：2010-05-01 00:00:00

abstract：:Plasma cells play a pivotal role in the immune system and are responsible for the synthesis and release of immunoglobulins. Numerous in vitro culture experiments on the yolk sac demonstrated the generation of mature cells of the myeloid and lymphoid lineages under appropriate culture conditions. However, there are no ...

journal_title：Immunology and cell biology

authors： El-Nefiawy N,Abdel-Hakim K,Kanayama N,Suganuma N,Terao T

更新日期：2003-10-01 00:00:00

abstract：:Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...

journal_title：Immunology and cell biology

authors： Taylor-Robinson AW

更新日期：1997-04-01 00:00:00

abstract：:Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...

journal_title：Immunology and cell biology

authors： Marsland BJ,Camberis M,Le Gros G

更新日期：2005-02-01 00:00:00

abstract：:The cellular effects of biodiesel emissions particulate matter (BDEP) and petroleum diesel emissions particulate matter (PDEP) were compared using a human airway cell line, A549. At concentrations of 25 microg/ml, diesel particulate matter induced the formation of multinucleate cells. In cells treated with a mixture o...

journal_title：Immunology and cell biology

authors： Ackland ML,Zou L,Freestone D,van de Waasenburg S,Michalczyk AA

更新日期：2007-11-01 00:00:00

abstract：:Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRR...

journal_title：Immunology and cell biology

authors： Yu L,Liu G,Yang C,Song X,Wang H

更新日期：2016-10-01 00:00:00

abstract：:The surface phenotype of T cells reflects both their relative maturity and their activation state. To determine the pattern of surface markers characteristic of activated T cells, purified mature T cells were stimulated in vitro for periods of 0.5-5 days with Concanavalin-A (Con-A) or phorbol myristic acetate (PMA) an...

journal_title：Immunology and cell biology

authors： Kelly K,Shortman K,Scollay R

更新日期：1988-08-01 00:00:00

abstract：:Inappropriate activation of p34cdc2 kinase has been shown to occur during apoptosis induced by cytotoxic T-cell derived perforin and fragmentin. We analysed the effect of two inhibitors of p34cdc2 kinase on alloreactive Tc-cell-mediated lysis and DNA fragmentation of P815 and L1210 target cells. Olomoucine, a specific...

journal_title：Immunology and cell biology

authors： Waring P,Müllbacher A

更新日期：2001-06-01 00:00:00

abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

journal_title：Immunology and cell biology

authors： Fernando SL,Britton WJ

更新日期：2006-04-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies ...

journal_title：Immunology and cell biology

authors： Shibata T,Ato M

更新日期：2017-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Studies in mice and humans have identified a role for microglial cells, th...

journal_title：Immunology and cell biology

authors： Webers A,Heneka MT,Gleeson PA

更新日期：2020-01-01 00:00:00

abstract：:Interferon regulatory factor (IRF) family members impart cell-type specificity to toll-like receptor (TLR) signalling, and we recently identified a role for IRF6 in TLR2 signalling in epithelial cells. TLR3 has a well-characterized role in wound healing in the skin, and here, we examined TLR3-dependent IRF6 functions ...

journal_title：Immunology and cell biology

authors： Ramnath D,Tunny K,Hohenhaus DM,Pitts CM,Bergot AS,Hogarth PM,Hamilton JA,Kapetanovic R,Sturm RA,Scholz GM,Sweet MJ

更新日期：2015-10-01 00:00:00

abstract：:The alpha-gal epitope (Galalpha1-3Galbeta1-(3)4GlcNAc-R) is abundantly synthesized on glycolipids and glycoproteins of non-primate mammals and New World monkeys by the glycosylation enzyme alpha1,3galactosyltransferase (alpha1,3GT). In humans, apes and Old World monkeys, this epitope is absent because the alpha1,3GT g...

journal_title：Immunology and cell biology

authors： Galili U

更新日期：2005-12-01 00:00:00

abstract：:The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of th...

journal_title：Immunology and cell biology

authors： Dockree T,Holland CJ,Clement M,Ladell K,McLaren JE,van den Berg HA,Gostick E,L Miners K,Llewellyn-Lacey S,Bridgeman JS,Man S,Bailey M,Burrows SR,Price DA,Wooldridge L

更新日期：2017-01-01 00:00:00

abstract：:Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. These proteins are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. Because differential splicing pro...

journal_title：Immunology and cell biology

authors： Rebollo A,Schmitt C

更新日期：2003-06-01 00:00:00

abstract：:Many specific antiviral and antitumour immune responses have been attributed to the protective effects of antigen-specific CD8+ cytotoxic T lymphocytes (CTL). Recognition of virus infected or tumour cells by CTL requires presentation of at least one peptide epitope from a virus or tumour-specific antigen by the releva...

journal_title：Immunology and cell biology

authors： Khammanivong V,Liu XS,Liu WJ,Rodda SJ,Leggatt GR,Tindle RW,Frazer IH,Fernando GJ

更新日期：2003-02-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite causative of clinical infections in a wide range of animal hosts. The maturation and activation of splenic conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were studied here in BALB/c mice challenged intraperitoneal with N. caninum tachyzoites. The nu...

journal_title：Immunology and cell biology

authors： Teixeira L,Botelho AS,Mesquita SD,Correia A,Cerca F,Costa R,Sampaio P,Castro AG,Vilanova M

更新日期：2010-01-01 00:00:00

abstract：:The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases such as diabetes mellitus have recently been associated with a disequilibrium between Id(+) and anti-Id Abs. However, it is unknown how Abs carrying complementa...

journal_title：Immunology and cell biology

authors： Jacobsen JT,Lunde E,Sundvold-Gjerstad V,Munthe LA,Bogen B

更新日期：2010-07-01 00:00:00

abstract：:Regulating the strength and class of an immune response requires lymphocytes to act as complex signal integrating "machines", taking information from multiple sources while making decisions that affect the final outcome. Describing and understanding the decision-making behaviour of lymphocytes within the context of th...

journal_title：Immunology and cell biology

authors： Hodgkin PD

更新日期：2007-06-01 00:00:00

abstract：:CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. On T cells the extracellular domain of CD45 is expressed in several different isoforms, and the particular isoform(s) expressed depends ...

journal_title：Immunology and cell biology

authors： Altin JG,Sloan EK

更新日期：1997-10-01 00:00:00

abstract：:The role of plasmacytoid dendritic cells (pDC) in anti-HIV immunity is mostly represented by the production of type I IFN in response to HIV infection in vitro and in vivo. This production is decreased in HIV-1 infected patients at the time of primary infection and during chronic disease in association with progressio...

journal_title：Immunology and cell biology

authors： Müller-Trutwin M,Hosmalin A

更新日期：2005-10-01 00:00:00

abstract：:Endothelial cell (EC)-neutrophil (PMN) interactions are crucial in the resolution of bacterial infections. Prokaryotic RNA (pRNA) has been reported as a pathogen-associated molecular pattern that is released from bacteria upon death and is able to activate PMN. In this work, we studied the effects of pRNA on EC and in...

journal_title：Immunology and cell biology

authors： Castillo LA,Birnberg Weiss F,Rodriguez-Rodrigues N,Pittaluga JR,Martire-Greco D,Milillo MA,Grinstein SF,Camelli MR,Mena Aybar AJ,Landoni VI,Fernández GC

更新日期：2019-10-01 00:00:00

abstract：:The expression of antigens in transgenic plants has been increasingly used in the development of experimental vaccines, particularly oriented to the development of edible vaccines. Hence, this technology becomes highly suitable to express immunogenic proteins from pathogens. Foot and mouth disease virus, bovine rotavi...

journal_title：Immunology and cell biology

authors： Dus Santos MJ,Wigdorovitz A

更新日期：2005-06-01 00:00:00

abstract：:Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentatio...

journal_title：Immunology and cell biology

authors： Hill AB

更新日期：1996-12-01 00:00:00