Immunochemotherapy of human colon carcinoma xenografts in nude mice using combinations of idarubicin-monoclonal antibody conjugates.

abstract：:Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...

journal_title：Immunology and cell biology

authors： Iba Y,Kurosawa Y

更新日期：1997-04-01 00:00:00

abstract：:The secreted hexameric form of the dengue virus (DENV) non-structural protein 1 (NS1) has recently been shown to elicit inflammatory cytokine release and disrupt endothelial cell monolayer integrity. This suggests that circulating NS1 contributes to the vascular leak that plays a major role in the pathology of dengue ...

journal_title：Immunology and cell biology

authors： Modhiran N,Watterson D,Blumenthal A,Baxter AG,Young PR,Stacey KJ

更新日期：2017-05-01 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapy has recently demonstrated a great potential for clinical applications; however, additional progress in the methods of tumor-specific antigen delivery to DCs is necessary for the further development of anti-tumor vaccines. To this end, a capsid-optimized adeno-associated virus se...

journal_title：Immunology and cell biology

authors： Pandya J,Ortiz L,Ling C,Rivers AE,Aslanidi G

更新日期：2014-02-01 00:00:00

abstract：:Productive immune responses to T-cell-dependent antigens ultimately generate two long-lived compartments: memory B cells and bone marrow-resident plasma cells, which both arise from within germinal centres. The ability of a B-cell clone to populate these effector compartments requires its descendents to outcompete tho...

journal_title：Immunology and cell biology

authors： Tarlinton DM

更新日期：2008-02-01 00:00:00

abstract：:Two related folate antagonists aminopterin (AMN) and methotrexate (MTX) were used to produce drug-antibody conjugates and their tumouricidal effects compared in vitro and in vivo. Active ester derivatives were produced with the use of N-hydroxysuccinimide (NHS) and covalently coupled to monoclonal antibodies (MoAb) re...

journal_title：Immunology and cell biology

authors： Kanellos J,Pietersz GA,Cunningham Z,McKenzie IF

更新日期：1987-12-01 00:00:00

abstract：:Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...

journal_title：Immunology and cell biology

authors： Logan GJ,Wang L,Zheng M,Coppel RL,Alexander IE

更新日期：2010-02-01 00:00:00

abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

journal_title：Immunology and cell biology

authors： Fernando SL,Britton WJ

更新日期：2006-04-01 00:00:00

abstract：:Thy-1 (CD90) expressed by mouse T cells is known to have signal transducing properties, but the ability of Thy-1 to enhance cytotoxic T lymphocyte (CTL) development is not well understood. Here we show that stimulation of mouse T cells with monoclonal antibodies (mAb) to CD3, CD28 and Thy-1 (clone G7), which were coim...

journal_title：Immunology and cell biology

authors： Haeryfar SM,Conrad DM,Musgrave B,Hoskin DW

更新日期：2005-08-01 00:00:00

abstract：:Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the pheno...

journal_title：Immunology and cell biology

authors： Gámez-Díaz L,Neumann J,Jäger F,Proietti M,Felber F,Soulas-Sprauel P,Perruzza L,Grassi F,Kögl T,Aichele P,Kilimann M,Grimbacher B,Jung S

更新日期：2017-10-01 00:00:00

abstract：:The ability to accurately quantitate and experimentally examine epigenetic modifications across the human genome has exploded in the past decade. This has given rise to a wealth of new information concerning the contributions of epigenetic regulatory networks to the pathogenesis of human disease. In particular, immuno...

journal_title：Immunology and cell biology

authors： MacDonald IA,Hathaway NA

更新日期：2015-03-01 00:00:00

abstract：:There is little evidence that cutaneous dendritic cells (DC), including epidermal Langerhans cells (LC), can induce immunity to UV radiation (UVR)-induced skin tumours. Here, it is shown that cells within skin can induce protective antitumour immunity against a UVR-induced fibrosarcoma. Transplantation of the skin ove...

journal_title：Immunology and cell biology

authors： Sluyter R,Yuen KS,Halliday GM

更新日期：2001-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are abundant small molecules of ≈ 22 nucleotides that reprogram gene expression by targeting mRNA degradation and translation disruption. An emerging concept implicates miRNA coupling with transcription factors in myeloid-based development of dendritic cells, monocytes and granulocytes, as well as f...

journal_title：Immunology and cell biology

authors： El Gazzar M,McCall CE

更新日期：2012-07-01 00:00:00

abstract：:Mycobacterium tuberculosis uses numerous mechanisms to avoid elimination by the infected host. In this study, we investigated the possibility whether, similar to other pathogens, M. tuberculosis exploits natural CD4+ CD25+ T-regulatory cells (Treg) to suppress the effector function of responding host lymphocytes, thus...

journal_title：Immunology and cell biology

authors： Quinn KM,McHugh RS,Rich FJ,Goldsack LM,de Lisle GW,Buddle BM,Delahunt B,Kirman JR

更新日期：2006-10-01 00:00:00

abstract：:The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4). These three MS4A family members are expressed on the cell surface of specific leukocyte subsets and have been well characterized as having key roles in ...

journal_title：Immunology and cell biology

authors： Eon Kuek L,Leffler M,Mackay GA,Hulett MD

更新日期：2016-01-01 00:00:00

abstract：:Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype ...

journal_title：Immunology and cell biology

authors： Westhorpe CL,Maisa A,Spelman T,Hoy JF,Dewar EM,Karapanagiotidis S,Hearps AC,Cheng WJ,Trevillyan J,Lewin SR,Sviridov D,Elliott JH,Jaworowski A,Dart AM,Crowe SM

更新日期：2014-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent cancers worldwide with rising mortality rates predicted in the coming decades. In light of this, there is a continued need for improvement in our understanding of CRC biology and the development of novel treatment options. Tumor-derived extracellular vesicles (tEVs)...

journal_title：Immunology and cell biology

authors： Manning S,Danielson KM

更新日期：2018-03-25 00:00:00

abstract：:The surface phenotype of T cells reflects both their relative maturity and their activation state. To determine the pattern of surface markers characteristic of activated T cells, purified mature T cells were stimulated in vitro for periods of 0.5-5 days with Concanavalin-A (Con-A) or phorbol myristic acetate (PMA) an...

journal_title：Immunology and cell biology

authors： Kelly K,Shortman K,Scollay R

更新日期：1988-08-01 00:00:00

abstract：:Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immunoinhibi...

journal_title：Immunology and cell biology

authors： Eglezos A,Andrews PV,Helme RD

更新日期：1993-04-01 00:00:00

abstract：:Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRR...

journal_title：Immunology and cell biology

authors： Yu L,Liu G,Yang C,Song X,Wang H

更新日期：2016-10-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells are multipotent cells capable of differentiating into different mesodermal cell types. Enigmatically, mesenchymal stromal cells present in the bone marrow support early lymphopoiesis yet can inhibit mature lymphocyte growth. Critical features of the bone marrow microenvironment, s...

journal_title：Immunology and cell biology

authors： Prado-Lòpez S,Duffy MM,Baustian C,Alagesan S,Hanley SA,Stocca A,Griffin MD,Ceredig R

更新日期：2014-08-01 00:00:00

abstract：:Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient...

journal_title：Immunology and cell biology

authors： Ramsbottom KM,Sacirbegovic F,Hawkins ED,Kallies A,Belz GT,Van Ham V,Haynes NM,Durrant MJ,Humbert PO,Russell SM,Oliaro J

更新日期：2016-03-01 00:00:00

abstract：:Infection of mice with the flaviviruses West Nile virus (WNV) and Murray Valley encephalitis (MVE) induces cytolytic T-cell responses which are highly cross-reactive on target cells infected with heterologous flaviviruses. Of C57BL/6 mice infected with low doses (10(2)-10(6) PFU) of either virus, 30-40% develop enceph...

journal_title：Immunology and cell biology

authors： Wang Y,Lobigs M,Lee E,Müllbacher A

更新日期：2004-04-01 00:00:00

abstract：:Granzyme B-expressing (GrB+) B cells are thought to contribute to immune dysfunctions in HIV patients, but so far their exact role is unknown. This report demonstrates for the first time the existence of GrB+ B cells in SIV-infected rhesus macaques, which represent the most commonly used nonhuman primate model for HIV...

journal_title：Immunology and cell biology

authors： Kotb A,Klippert A,Daskalaki M,Sauermann U,Stahl-Hennig C,Neumann B

更新日期：2017-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Studies in mice and humans have identified a role for microglial cells, th...

journal_title：Immunology and cell biology

authors： Webers A,Heneka MT,Gleeson PA

更新日期：2020-01-01 00:00:00

abstract：:FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that express...

journal_title：Immunology and cell biology

authors： Ye L,Goodall JC,Zhang L,Putintseva EV,Lam B,Jiang L,Liu W,Yin J,Lin L,Li T,Wu X,Yeo G,Shugay M,Chudakov DM,Gaston H,Xu H

更新日期：2016-03-01 00:00:00

abstract：:The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...

journal_title：Immunology and cell biology

authors： Deenick EK

更新日期：2020-07-01 00:00:00

abstract：:The iscom is a delivery system, designed for both parenteral and mucosal modes of administration, for both antigens and adjuvants, components which are interchangeable. By the parenteral route a prominent systemic Th1 type of response is evoked, but the mucosal immunoglobulin A (IgA) response was insignificant. Intran...

journal_title：Immunology and cell biology

authors： Morein F,Bengtsson KL

更新日期：1998-08-01 00:00:00

abstract：:T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC ...

journal_title：Immunology and cell biology

authors： Zanker D,Quinn K,Waithman J,Lata R,Murphy R,La Gruta NL,Chen W

更新日期：2015-05-01 00:00:00

abstract：:Early pregnancy factor (EPF), an extracellular chaperonin 10 homologue, has immunosuppressive and growth factor properties. In order to carry out more extensive studies on the in vivo characteristics of EPF, a recombinant form of the molecule has been prepared. Recombinant human EPF (rEPF) was expressed in Escherichia...

journal_title：Immunology and cell biology

authors： Morton H,McKay DA,Murphy RM,Somodevilla-Torres MJ,Swanson CE,Cassady AI,Summers KM,Cavanagh AC

更新日期：2000-12-01 00:00:00

abstract：:Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...

journal_title：Immunology and cell biology

authors： Ruszala-Mallon V,Silva J,Lumanglas AL,Durr FE,Wang BS

更新日期：1991-02-01 00:00:00