Abstract:
:Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immunoinhibitory effect of somatostatin on the rat popliteal lymph node lymphocyte primary antibody response to sheep red blood cell (SRBC) stimulation. Infusion of somatostatin immediately following SRBC injection into the hind feet of rats had a dose-related inhibitory effect. At the highest concentration used, 10 mumol/L, the level of inhibition was similar to that previously described following neonatal capsaicin treatment of rats. This suggests that neonatal capsaicin treatment may lead to decreased primary antibody responses to SRBC by a selective effect on tachykinin containing nerves and a lesser effect on somatostatin containing nerves. The immunoinhibitory effect of somatostatin was reversed by co-infusion of neurokinin A but not substance P, both of which have been shown to stimulate this response. This suggests the possibility that multiple tachykinin receptors are involved in the modulation of the SRBC primary antibody response in vivo. These results present evidence for an in vivo immunomodulatory role of somatostatin.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Eglezos A,Andrews PV,Helme RDdoi
10.1038/icb.1993.13subject
Has Abstractpub_date
1993-04-01 00:00:00pages
125-9eissn
0818-9641issn
1440-1711journal_volume
71 ( Pt 2)pub_type
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