Abstract：
:Natural killer (NK) cells are potent immune effector cells that can respond to infection and cancer, as well as allowing maternal adaptation to pregnancy. In response to malignant transformation or pathogenic invasion, NK cells can secrete cytokine and may be directly cytolytic, as well as exerting effects indirectly through other cells of the immune system. To recognize and respond to inflamed or infected tissues, NK cells express a variety of activating and inhibitory receptors including NKG2D, Ly49 or KIR, CD94-NKG2 heterodimers and natural cytotoxicity receptors, as well as co-stimulatory receptors. These receptors recognize cellular stress ligands as well as major histocompatibility complex class I and related molecules, which can lead to NK cell responses. Importantly, NK cells must remain tolerant of healthy tissue, and some of these receptors can also prevent activation of NK cells. In this review, we describe the expression of prominent NK cell receptors, as well as expression of their ligands and their role in immune responses. In addition, we describe the main signaling pathways used by NK cell receptors. Although we now appreciate that NK cell biology is more complicated than first thought, there are still facets of their biology that remain unclear. These will be highlighted and discussed in this review.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Pegram HJ,Andrews DM,Smyth MJ,Darcy PK,Kershaw MHdoi
10.1038/icb.2010.78subject
Has Abstractpub_date
2011-02-01 00:00:00pages
216-24issue
2eissn
0818-9641issn
1440-1711pii
icb201078journal_volume
89pub_type
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pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2007-02-01 00:00:00
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更新日期：2009-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：1993-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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更新日期：2016-03-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：1995-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/sj.icb.7100061
更新日期：2007-06-01 00:00:00
