Abstract：
:A derivative of ammonia caramel colour (AC) is known to induce a selective lymphopenia in rats. Accordingly, the haematological effects were studied in mice of oral administration in drinking water of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), the component of AC responsible for lymphopenia. Initially five groups of BALB/c mice (five mice per group) were given doses of THI ranging from 0 to 200 parts/10(6) and bled weekly. Doses of THI from 5 to 100 parts/10(6) had no effect on circulating leucocytes over 6 weeks, but lymphopenia occurred with 200 parts/10(6). An increase in the concentration of THI to 400 parts/10(6) in the group on the lowest dose resulted in lymphopenia. An increase in dosage in two groups of mice, to 1000 and 2000 parts/10(6), resulted in marked lymphopenia. The number of neutrophils, eosinophils and monocytes remained unchanged throughout the experiment. Measurement of the proportions of CD4(L3T4)+ and CD8(Ly2)+ lymphocytes in lymph nodes from mice on high doses of THI did not show a selective depression of either subset, although both were increased relative to non-T cells. THI causes a selective lymphopenia in mice, as in rats, but at relatively higher doses, and merits investigation in mice as an experimental treatment for states of lymphocyte excess or overactivity.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Iscaro A,Mackay IR,O'Brien Cdoi
10.1038/icb.1988.51subject
Has Abstractpub_date
1988-10-01 00:00:00pages
395-402eissn
0818-9641issn
1440-1711journal_volume
66 ( Pt 5-6)pub_type
杂志文章abstract：:Two related folate antagonists aminopterin (AMN) and methotrexate (MTX) were used to produce drug-antibody conjugates and their tumouricidal effects compared in vitro and in vivo. Active ester derivatives were produced with the use of N-hydroxysuccinimide (NHS) and covalently coupled to monoclonal antibodies (MoAb) re...
journal_title：Immunology and cell biology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Immunology and cell biology
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pub_type： 杂志文章
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1999.00825.x
更新日期：1999-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1988.43
更新日期：1988-10-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：1999-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2015.106
更新日期：2016-03-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2017.5
更新日期：2017-05-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 社论
doi：10.1111/imcb.12348
更新日期：2020-07-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/sj.icb.7100148
更新日期：2008-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1998.00768.x
更新日期：1998-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1992-10-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2009-11-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：Immunology and cell biology
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更新日期：2013-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：1994-04-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：1997-12-01 00:00:00
abstract：:The cellular effects of biodiesel emissions particulate matter (BDEP) and petroleum diesel emissions particulate matter (PDEP) were compared using a human airway cell line, A549. At concentrations of 25 microg/ml, diesel particulate matter induced the formation of multinucleate cells. In cells treated with a mixture o...
journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1111/imcb.12001
更新日期：2018-05-01 00:00:00
