Abstract：
:The ability to accurately quantitate and experimentally examine epigenetic modifications across the human genome has exploded in the past decade. This has given rise to a wealth of new information concerning the contributions of epigenetic regulatory networks to the pathogenesis of human disease. In particular, immunological disorders have strong developmental roots in chromatin regulatory pathways. In this review, we focus on the epigenetic signatures and new discoveries revealing the epigenetic compositions of specific immunological cancers and autoimmune diseases. We also comment on the conserved epigenetic roots among diverse immunological disorders and suggest inhibition strategies that may be relevant for future treatment. Finally, we highlight emerging experimental tools with the capability to examine the mechanisms of chromatin regulatory enzymes with a high level of temporal control. The knowledge of genetic and epigenetic defects in immunological disease combined with new experimental approaches will elucidate the contribution of individual enzymes in complex epigenetic regulatory networks. This could lead to new diagnostic and therapeutic approaches for some very diverse and difficult to treat human diseases.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
MacDonald IA,Hathaway NAdoi
10.1038/icb.2014.105subject
Has Abstractpub_date
2015-03-01 00:00:00pages
261-70issue
3eissn
0818-9641issn
1440-1711pii
icb2014105journal_volume
93pub_type
杂志文章,评审abstract：:Brucellosis remains a significant zoonotic threat worldwide. Humans and animals acquire infection via their oropharynx and upper respiratory tract following oral or aerosol exposure. After mucosal infection, brucellosis develops into a systemic disease. Mucosal vaccination could offer a viable alternative to conventio...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2016.5
更新日期：2016-05-01 00:00:00
abstract：:Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentatio...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1996.85
更新日期：1996-12-01 00:00:00
abstract：:Natural killer (NK) cells are potent immune effector cells that can respond to infection and cancer, as well as allowing maternal adaptation to pregnancy. In response to malignant transformation or pathogenic invasion, NK cells can secrete cytokine and may be directly cytolytic, as well as exerting effects indirectly ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2010.78
更新日期：2011-02-01 00:00:00
abstract：:Activins and inhibins are members of the transforming growth factor-β superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2011.32
更新日期：2012-02-01 00:00:00
abstract：:Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen-specific T cells into a coordinated evolution of effector and memory outcomes. The T cell receptor (TCR) repertoire is highly diverse to account for the highly heterogeneous antigenic world. During...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2016.16
更新日期：2016-07-01 00:00:00
abstract：:Immunization of Lewis rats with guinea-pig myelin basic protein (Gp-MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encep...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1998.00720.x
更新日期：1998-02-01 00:00:00
abstract：:The mechanisms involved in the inhibition of growth of a human B lymphoma cell line, B104, by anti-MHC class II antibodies (Ab) were compared with those in anti-IgM Ab-induced B104 growth inhibition. Two anti-MHC class II Ab, L227 and 2.06, inhibited the growth of B104 cells, although 2.06, but not L227, needed to be ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1994.31
更新日期：1994-06-01 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is typically associated with extensive and progressive fibrosis, and is fatal and has limited treatment options. Characteristically IPF patients display large lymphocyte aggregates composed of CD3+ T cells and CD20+ B ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2017.22
更新日期：2017-08-01 00:00:00
abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2009.30
更新日期：2009-07-01 00:00:00
abstract：:Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2004.01303.x
更新日期：2005-02-01 00:00:00
abstract：:Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2015.45
更新日期：2015-10-01 00:00:00
abstract：:Ficolins are important and widely distributed pattern recognition molecules that can induce lectin complement pathway activation and initiate the innate immune response. Although ficolins can bind lipopolysaccharide (LPS) in vitro, the sources, dynamic changes and roles of local ficolins in LPS-induced pulmonary infla...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12344
更新日期：2020-08-01 00:00:00
abstract：:Multipotent mesenchymal stromal cells are multipotent cells capable of differentiating into different mesodermal cell types. Enigmatically, mesenchymal stromal cells present in the bone marrow support early lymphopoiesis yet can inhibit mature lymphocyte growth. Critical features of the bone marrow microenvironment, s...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2014.30
更新日期：2014-08-01 00:00:00
abstract：:The possible role and influence of tumour necrosis factor-alpha (TNF-alpha) in the human mixed lymphocyte culture (MLC) reaction was investigated. Polyclonal rabbit sera to recombinant human-TNF-alpha (rhTNF-alpha) consistently inhibited the MLC, and this could be reversed by simultaneous addition of rhTNF-alpha to th...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1992.15
更新日期：1992-04-01 00:00:00
abstract：:There is little evidence that cutaneous dendritic cells (DC), including epidermal Langerhans cells (LC), can induce immunity to UV radiation (UVR)-induced skin tumours. Here, it is shown that cells within skin can induce protective antitumour immunity against a UVR-induced fibrosarcoma. Transplantation of the skin ove...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2001.00967.x
更新日期：2001-02-01 00:00:00
abstract：:Interferon regulatory factor (IRF) family members impart cell-type specificity to toll-like receptor (TLR) signalling, and we recently identified a role for IRF6 in TLR2 signalling in epithelial cells. TLR3 has a well-characterized role in wound healing in the skin, and here, we examined TLR3-dependent IRF6 functions ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2015.77
更新日期：2015-10-01 00:00:00
abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2002.01077.x
更新日期：2002-06-01 00:00:00
abstract：:Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2013.94
更新日期：2014-04-01 00:00:00
abstract：:Substance abuse is a growing world-wide problem. The big four drugs of abuse that might lend themselves to immunotherapy are nicotine, cocaine, morphine/heroin and methamphetamine. Tobacco abuse has a well-known enormous impact on major chronic cardiovascular and pulmonary diseases, while the last three, aside from th...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2009.17
更新日期：2009-05-01 00:00:00
abstract：:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/sj.icb.7100027
更新日期：2007-02-01 00:00:00
abstract：:Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2017.55
更新日期：2017-10-01 00:00:00
abstract：:Leishmaniasis, a group of visceral and cutaneous diseases, is caused by parasites belonging to one genus comprising approximately 13 different species. Many methods including serological, biochemical and molecular biological techniques have been used by various workers to characterize these different species and isola...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1998.00731.x
更新日期：1998-04-01 00:00:00
abstract：:Parturition is associated with myometrial and cervical inflammation. The causes and consequences of this inflammatory response are not clear. Mast cells (MCs) are important inducers of allergic and non-allergic inflammation, and their secreted products can induce myometrial contractions. Thus, mast cell activation has...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2011.40
更新日期：2012-03-01 00:00:00
abstract：:The utility of T-cell receptor (TCR) transgenic mice in medical research has been considerable, with applications ranging from basic biology all the way to translational and clinical investigations. Crossing of TCR transgenic mice with either recombination-activating gene (RAG)-1 or RAG-2 knockouts is frequently used ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12033
更新日期：2018-07-01 00:00:00
abstract：:Activin A, a member of the transforming growth factor-β superfamily, is a critical early mediator of acute inflammation. Activin A release coincides with the release of tumour necrosis factor-α (TNF-α) in models of lipopolysaccharide (LPS)-induced inflammation. The source of circulating activin A during acute inflamma...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2011.12
更新日期：2011-11-01 00:00:00
abstract：:The Australian populations of rainbow trout (Onchorhynchus mykiss) and Atlantic salmon (Salmo salar) were found to have similar immunological responses to local strains of Vibrio anguillarum as those reported for the more genetically diverse populations of these fish and strains of V. anguillarum found in the Northern...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1992.51
更新日期：1992-12-01 00:00:00
abstract：:After positive selection, the newly differentiated single-positive (SP) thymocytes undergo negative selection to eliminate autoreactive T cells, functional maturation to acquire immunocompetence and egress capability. To investigate whether the intracellular reduction/oxidation (redox) balance has an important role on...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2013.57
更新日期：2013-11-01 00:00:00
abstract：:Tamm-Horsfall protein (THP) binds strongly to complement 1q (C1q), a key component of the classical complement pathway. The goals of this study were to determine whether THP altered the activation of the classical complement pathway and whether the carbohydrate portion of THP was involved in this glycoprotein's bindin...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2006.01434.x
更新日期：2006-08-01 00:00:00
abstract：:Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in t...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1996.77
更新日期：1996-10-01 00:00:00
abstract：:Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. These proteins are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. Because differential splicing pro...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.2003.01159.x
更新日期：2003-06-01 00:00:00
