Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies.

abstract：:Inappropriate activation of p34cdc2 kinase has been shown to occur during apoptosis induced by cytotoxic T-cell derived perforin and fragmentin. We analysed the effect of two inhibitors of p34cdc2 kinase on alloreactive Tc-cell-mediated lysis and DNA fragmentation of P815 and L1210 target cells. Olomoucine, a specific...

journal_title：Immunology and cell biology

authors： Waring P,Müllbacher A

更新日期：2001-06-01 00:00:00

abstract：:A clone of cells secreting an antibody to an epidermal antigen was generated from a patient with a blistering skin lesion. Although produced by fusion of human lymphocytes to a HAT-sensitive myeloma, this clone of cells did not have characteristics of a hybridoma. A true hybridoma was produced by fusion of this clone ...

journal_title：Immunology and cell biology

authors： Hohmann AW,Coleman M,Comacchio RM,Skinner JM,Bradley J

更新日期：1988-01-01 00:00:00

abstract：:During an allergic inflammatory response in the airway, if a failure of the epithelial cell barrier occurs before the systemic immune response is triggered by allergens, more allergens can invade. Using a rat model of asthma, we previously found that mucosal mast cells, which localise to the epithelial layer of the ai...

journal_title：Immunology and cell biology

authors： Liu S,Shudou M,Maeyama K

更新日期：2011-02-01 00:00:00

abstract：:Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...

journal_title：Immunology and cell biology

authors： Taylor-Robinson AW

更新日期：1997-04-01 00:00:00

abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

journal_title：Immunology and cell biology

authors： Sanchez D,Ganfornina MD,Bastiani MJ

更新日期：1995-12-01 00:00:00

abstract：:Lymphocyte activation was examined by interleukin-2 (IL-2) receptor expression on peripheral blood mononuclear cells from coeliac and control subjects. Purified T cells were incubated with gluten fraction 111 (a known toxic peptide for coeliac subjects), soyabean hydrolysate (an unrelated hydrolysed food antigen), and...

journal_title：Immunology and cell biology

authors： Penttila IA,Gibson CE,Forrest BD,Cummins AG,LaBrooy JT

更新日期：1990-06-01 00:00:00

abstract：:Active Brugia pahangi microfilariae (Mf) were injected into naive male BALB/c mice intraperitoneally. Microfilaraemia was studied for 28 days; and Mf circulated in blood in optimum numbers from 3 to 14 days. Anti-Mf response was assessed by the rate of disappearance of Mf from blood as well as their absence from visce...

journal_title：Immunology and cell biology

authors： Rajasekariah GR,Puri PM,Chandrashekar R,Subrahmanyam D

更新日期：1988-10-01 00:00:00

abstract：:The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differen...

journal_title：Immunology and cell biology

authors： Venuprasad K,Zeng M,Baughan SL,Massoumi R

更新日期：2015-05-01 00:00:00

abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

journal_title：Immunology and cell biology

authors： Wilson NS,Villadangos JA

更新日期：2004-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Studies in mice and humans have identified a role for microglial cells, th...

journal_title：Immunology and cell biology

authors： Webers A,Heneka MT,Gleeson PA

更新日期：2020-01-01 00:00:00

abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...

journal_title：Immunology and cell biology

authors： Chin J,Turner B,Barchia I,Mullbacher A

更新日期：2000-02-01 00:00:00

abstract：:A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

journal_title：Immunology and cell biology

authors： Aalberse RC

更新日期：1996-04-01 00:00:00

abstract：:The germinal centre reaction (GCR) is a fundamental component of the immune response to T-dependent antigens, during which the immunoglobulin (Ig) genes of B cells experience somatic hypermutation and selection. A maximum-likelihood method on DNA sequence data from 16 individual germinal centres was used to infer that...

journal_title：Immunology and cell biology

authors： Radmacher MD,Kelsoe G,Kepler TB

更新日期：1998-08-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite causative of clinical infections in a wide range of animal hosts. The maturation and activation of splenic conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were studied here in BALB/c mice challenged intraperitoneal with N. caninum tachyzoites. The nu...

journal_title：Immunology and cell biology

authors： Teixeira L,Botelho AS,Mesquita SD,Correia A,Cerca F,Costa R,Sampaio P,Castro AG,Vilanova M

更新日期：2010-01-01 00:00:00

abstract：:The expression of antigens in transgenic plants has been increasingly used in the development of experimental vaccines, particularly oriented to the development of edible vaccines. Hence, this technology becomes highly suitable to express immunogenic proteins from pathogens. Foot and mouth disease virus, bovine rotavi...

journal_title：Immunology and cell biology

authors： Dus Santos MJ,Wigdorovitz A

更新日期：2005-06-01 00:00:00

abstract：:In the developing forebrain, mounting evidence suggests that neural stem cell proliferation and differentiation is regulated by growth factors. In vitro in the presence of serum, stem cell proliferation is predominantly mediated by fibroblast growth factor-2 (FGF-2) whereas neuronal differentiation can be triggered by...

journal_title：Immunology and cell biology

authors： Bartlett PF,Brooker GJ,Faux CH,Dutton R,Murphy M,Turnley A,Kilpatrick TJ

更新日期：1998-10-01 00:00:00

abstract：:Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen-specific T cells into a coordinated evolution of effector and memory outcomes. The T cell receptor (TCR) repertoire is highly diverse to account for the highly heterogeneous antigenic world. During...

journal_title：Immunology and cell biology

authors： Eltahla AA,Rizzetto S,Pirozyan MR,Betz-Stablein BD,Venturi V,Kedzierska K,Lloyd AR,Bull RA,Luciani F

更新日期：2016-07-01 00:00:00

abstract：:Here we examine the use of glycopeptides containing tumour-associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent results suggest that CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC-restricted fashion. The ThomsenFriedenreich antigen (TF), ...

journal_title：Immunology and cell biology

authors： Xu Y,Sette A,Sidney J,Gendler SJ,Franco A

更新日期：2005-08-01 00:00:00

abstract：:The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...

journal_title：Immunology and cell biology

authors： Zanker D,Pang K,Oveissi S,Lu C,Faou P,Nowell C,Mbogo GW,Carotta S,Quillici C,Karupiah G,Hibbs ML,Nutt SL,Neeson P,Puthalakath H,Chen W

更新日期：2018-10-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

journal_title：Immunology and cell biology

authors： Simone LC,Wang X,Tuli A,Solheim JC

更新日期：2010-01-01 00:00:00

abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

journal_title：Immunology and cell biology

authors： Lipoldová M,Holán V

更新日期：1991-12-01 00:00:00

abstract：:Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized the programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, and investigated their influence on helper T (Th) cell responses. Although a...

journal_title：Immunology and cell biology

authors： Tavukcuoglu E,Horzum U,Yilmaz KB,Esendagli G

更新日期：2020-02-01 00:00:00

abstract：:Retinoic acid (RA) in the steady state enhances induction of Foxp3(+) regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby maintaining tolerance, but can in inflammatory conditions promote effector Th1 and Th17 cells that mediate inflammation. IL-17-producing γδ T cells have recently b...

journal_title：Immunology and cell biology

authors： Raverdeau M,Breen CJ,Misiak A,Mills KH

更新日期：2016-09-01 00:00:00

abstract：:The ability of a tunicate immunomodulatory protein, tunIL1, to interact with mammalian cells was investigated. TunIL1 is known to regulate inflammatory defence reactions in tunicates and to stimulate the proliferation of mammalian thymocytes. In the current study, tunIL1 was shown to enchance L929 fibroblast prolifera...

journal_title：Immunology and cell biology

authors： Raftos D

更新日期：1996-02-01 00:00:00

abstract：:Concanavalin A (Con A)-induced hepatitis is thought to be a T-cell-mediated disease with active destruction of liver cells. Interleukin (IL)-17 is a cytokine produced principally by CD4(+) T cells. However, whether IL-17/IL-17 receptor (IL-17/IL-17R)-mediated responses are involved in T-cell-mediated Con A-induced liv...

journal_title：Immunology and cell biology

authors： Yan S,Wang L,Liu N,Wang Y,Chu Y

更新日期：2012-04-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...

journal_title：Immunology and cell biology

authors： Abdel-Nour M,Tsalikis J,Kleinman D,Girardin SE

更新日期：2014-04-01 00:00:00

abstract：:The molecular interactions between the T-cell receptor (TCR) and peptide-MHC (pMHC) have been elucidated in recent years. Nevertheless, the fact that binding of only slightly different ligands by a TCR, or ligation of the same pMHC at different developmental stages of the T cell, can have opposing consequences, contin...

journal_title：Immunology and cell biology

authors： Regner M

更新日期：2001-04-01 00:00:00

abstract：:Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing several inhibitors. A novel peroxidase detection system was used and te...

journal_title：Immunology and cell biology

authors： Shuler RL,Owen CS

更新日期：1993-02-01 00:00:00

abstract：:Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRR...

journal_title：Immunology and cell biology

authors： Yu L,Liu G,Yang C,Song X,Wang H

更新日期：2016-10-01 00:00:00

abstract：:CD4(+) T cells are activated upon recognition of peptide antigen in the context of MHC class II molecules, expressed by specialized APC. In this study, we show that CD4(+) T cells cross-compete for antigenic complexes on the surface of APC, inhibiting activation of other potentially reactive T cells of the same and di...

journal_title：Immunology and cell biology

authors： Hayball JD,Robinson BW,Lake RA

更新日期：2004-04-01 00:00:00