Serological responses and immunity produced in salmonids by vaccination with Australian strains of Vibrio anguillarum.

abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...

journal_title：Immunology and cell biology

authors： Bretscher PA

更新日期：1992-10-01 00:00:00

abstract：:Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...

journal_title：Immunology and cell biology

authors： Marsland BJ,Camberis M,Le Gros G

更新日期：2005-02-01 00:00:00

abstract：:The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-K...

journal_title：Immunology and cell biology

authors： van Nieuwenhuijze AE,Cauwe B,Klatt D,Humblet-Baron S,Liston A

更新日期：2015-11-01 00:00:00

abstract：:Fluorescent dyes are increasingly being exploited to track lymphocyte migration and proliferation. The present paper reviews the properties and performance of some 14 different fluorescent dyes that have been used during the last 20 years to monitor lymphocyte migration. Of the 14 dyes discussed, two stand out as bein...

journal_title：Immunology and cell biology

authors： Parish CR

更新日期：1999-12-01 00:00:00

abstract：:Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...

journal_title：Immunology and cell biology

authors： Coquet JM,Rausch L,Borst J

更新日期：2015-10-01 00:00:00

abstract：:Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory...

journal_title：Immunology and cell biology

authors： Almudevar A

更新日期：2017-10-01 00:00:00

abstract：:Regulatory mechanisms in mucosal secretions and tissues recognize antigens and attenuate pro-inflammatory cytokine responses. Here, we asked whether human beta-defensin 3 (HBD3) serves as an upstream suppressor of cytokine signaling that binds and attenuates pro-inflammatory cytokine responses to recombinant hemagglut...

journal_title：Immunology and cell biology

authors： Pingel LC,Kohlgraf KG,Hansen CJ,Eastman CG,Dietrich DE,Burnell KK,Srikantha RN,Xiao X,Bélanger M,Progulske-Fox A,Cavanaugh JE,Guthmiller JM,Johnson GK,Joly S,Kurago ZB,Dawson DV,Brogden KA

更新日期：2008-11-01 00:00:00

abstract：:Interleukin-4 (IL-4) has previously been implicated in a protective response to Staphylococcus aureus corneal infection. Consequently, the specific role of IL-4 during S. aureus corneal infection was investigated using IL-4 gene knockout mice. The eyes of IL-4-/- mice and wild-type mice were challenged topically with ...

journal_title：Immunology and cell biology

authors： Cole N,Hume EB,Khan S,Garthwaite L,Schubert T,Reeve V,Willcox MD

更新日期：2007-06-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...

journal_title：Immunology and cell biology

authors： Abdel-Nour M,Tsalikis J,Kleinman D,Girardin SE

更新日期：2014-04-01 00:00:00

abstract：:Tumour cell heterogeneity is probably a principal cause of treatment failure and represents a formidable barrier for effective antibody-targeted chemotherapy. Idarubicin (Ida), a more potent and less cardiotoxic analogue of daunomycin, has been demonstrated to specifically target and eradicate homogeneous, cloned, mur...

journal_title：Immunology and cell biology

authors： Smyth MJ,Foster HM,Andrew SM,Teh JG,Krauer K,McKenzie IF,Pietersz GA

更新日期：1993-06-01 00:00:00

abstract：:A murine monoclonal antibody has been used to characterise a 45,000 Da antigen that is associated with the surface membrane of merozoites of the human malaria parasite Plasmodium falciparum. The antigen is a glycoprotein and incorporates myristic acid. ...

journal_title：Immunology and cell biology

authors： Ramasamy R

更新日期：1987-10-01 00:00:00

abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

journal_title：Immunology and cell biology

authors： Wilson NS,Villadangos JA

更新日期：2004-02-01 00:00:00

abstract：:Three murine monoclonal antibodies (BC1, BC2 and BC3) were developed against human milk fat globule membrane (HMFGM). By immunoperoxidase staining, it was found that the antigenic determinants had a predominant distribution in breast cancer tissue. In addition, the antibodies reacted preferentially with mucin derived ...

journal_title：Immunology and cell biology

authors： Xing PX,Tjandra JJ,Stacker SA,Teh JG,Thompson CH,McLaughlin PJ,McKenzie IF

更新日期：1989-06-01 00:00:00

abstract：:NK cell activity has been detected in the early murine decidua, and hypothesized to be mediated by granulated metrial gland (GMG) cells. The possibility that natural cytotoxic (NC) cells are also present in the decidua has not been investigated. In this study mAb to NK cells (anti-NK-1.1) and NC cells (anti-NC-1.1) we...

journal_title：Immunology and cell biology

authors： Clarke GR,Roberts TK,Smart YC

更新日期：1994-04-01 00:00:00

abstract：:Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown. Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression t...

journal_title：Immunology and cell biology

authors： Liston A,Siggs OM,Goodnow CC

更新日期：2007-06-01 00:00:00

abstract：:FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that express...

journal_title：Immunology and cell biology

authors： Ye L,Goodall JC,Zhang L,Putintseva EV,Lam B,Jiang L,Liu W,Yin J,Lin L,Li T,Wu X,Yeo G,Shugay M,Chudakov DM,Gaston H,Xu H

更新日期：2016-03-01 00:00:00

abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

journal_title：Immunology and cell biology

authors： Sanchez D,Ganfornina MD,Bastiani MJ

更新日期：1995-12-01 00:00:00

abstract：:There has been a tremendous explosion in the area of DNA vaccine research over the last 4 years, particularly in relation to antiviral vaccines. This report discusses the development and application of this new technology with regard to parasitic infections. Progress has been made towards the development of a vaccine ...

journal_title：Immunology and cell biology

authors： Kalinna BH

更新日期：1997-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Studies in mice and humans have identified a role for microglial cells, th...

journal_title：Immunology and cell biology

authors： Webers A,Heneka MT,Gleeson PA

更新日期：2020-01-01 00:00:00

abstract：:The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differen...

journal_title：Immunology and cell biology

authors： Venuprasad K,Zeng M,Baughan SL,Massoumi R

更新日期：2015-05-01 00:00:00

abstract：:There is a need for non-living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Here we describe our experience with lipophilic immune-stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A. When given orally, ISCOMs containin...

journal_title：Immunology and cell biology

authors： Smith RE,Donachie AM,Mowat AM

更新日期：1998-06-01 00:00:00

abstract：:As previously reported by others for immunoglobulin (Ig)G, we observed that IgA can induce interleukin (IL)-10 expression in human monocytes. In this study, we explored the molecular mechanisms of IL-10 induction by IgA in monocytes and monocyte-derived dendritic cells (MD-DCs). Monomeric IgA induced IL-10 production ...

journal_title：Immunology and cell biology

authors： Pilette C,Detry B,Guisset A,Gabriels J,Sibille Y

更新日期：2010-05-01 00:00:00

abstract：:Mice infected with Sarcocystis muris showed a significant reduction in plaque-forming cells (PFC) and delayed-type hypersensitivity (DHS) responses to an unrelated protein antigen, bovine gamma-globulin, when compared with uninfected controls. This immunosuppression was observed only when infection preceded immunizati...

journal_title：Immunology and cell biology

authors： Gill HS,Charleston WA,Moriarty KM

更新日期：1988-01-01 00:00:00

abstract：:It has been described that polymorphonuclear neutrophils (PMNs) enhance the replication of CC-chemokine receptor 5/macrophage-tropic (R5) HIV in cultures of monocyte-derived macrophages (MDMs). In this study, the inhibitory effect of glycyrrhizin (GL) on R5 HIV replication influenced by PMNs was investigated in MDM cu...

journal_title：Immunology and cell biology

authors： Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F

更新日期：2009-10-01 00:00:00

abstract：:Asthma is a common and complex inflammatory disease of the airways that remains incurable. Current forms of therapy are long term and may exhibit associated side-effect problems. Major participants in the development of an asthma phenotype include the triggering stimuli such as the allergens themselves, cells such as ...

journal_title：Immunology and cell biology

authors： Ramshaw HS,Woodcock JM,Bagley CJ,McClure BJ,Hercus TR,Lopez AF

更新日期：2001-04-01 00:00:00

abstract：:There are estimated to be 350 million chronic carriers of hepatitis B infection worldwide. Patients with chronic hepatitis B are at risk of liver cirrhosis with associated mortality because of hepatocellular carcinoma and other complications. An important goal, therefore, is the development of an effective therapeutic...

journal_title：Immunology and cell biology

authors： Aguilar JC,Lobaina Y,Muzio V,García D,Pentón E,Iglesias E,Pichardo D,Urquiza D,Rodríguez D,Silva D,Petrovsky N,Guillén G

更新日期：2004-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is typically associated with extensive and progressive fibrosis, and is fatal and has limited treatment options. Characteristically IPF patients display large lymphocyte aggregates composed of CD3+ T cells and CD20+ B ...

journal_title：Immunology and cell biology

authors： Hoyne GF,Elliott H,Mutsaers SE,Prêle CM

更新日期：2017-08-01 00:00:00

abstract：:Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...

journal_title：Immunology and cell biology

authors： Taylor-Robinson AW

更新日期：1997-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), the β-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity. Among them, HCMV uses cellular captured genes encoding molecules capable of interfering with the original host function or of fulfilling new immunomodulatory tasks. Here, we report on UL7, ...

journal_title：Immunology and cell biology

authors： Engel P,Pérez-Carmona N,Albà MM,Robertson K,Ghazal P,Angulo A

更新日期：2011-10-01 00:00:00

abstract：:Mycobacterium tuberculosis uses numerous mechanisms to avoid elimination by the infected host. In this study, we investigated the possibility whether, similar to other pathogens, M. tuberculosis exploits natural CD4+ CD25+ T-regulatory cells (Treg) to suppress the effector function of responding host lymphocytes, thus...

journal_title：Immunology and cell biology

authors： Quinn KM,McHugh RS,Rich FJ,Goldsack LM,de Lisle GW,Buddle BM,Delahunt B,Kirman JR

更新日期：2006-10-01 00:00:00