Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages.

abstract：:Th-cell development has been suggested to include selective mechanisms in which certain cytokines select either Th1 or Th2 cells to proliferate and grow. The selective theory is based on the observation that Th2 cells secrete IL-4, a cytokine that promotes Th2 development, whereas Th1 cells secrete interferon-gamma (I...

journal_title：Immunology and cell biology

authors： Jansson A,Harlen M,Karlsson S,Nilsson P,Cooley M

更新日期：2007-04-01 00:00:00

abstract：:Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown. Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression t...

journal_title：Immunology and cell biology

authors： Liston A,Siggs OM,Goodnow CC

更新日期：2007-06-01 00:00:00

abstract：:Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to deat...

journal_title：Immunology and cell biology

authors： Vasilikos L,Spilgies LM,Knop J,Wong WW

更新日期：2017-02-01 00:00:00

abstract：:The discovery of functional long noncoding RNAs (lncRNAs) coupled with the ever-increasing accessibility of genomic and transcriptomic technology has led to an explosion of functional and mechanistic investigation and discovery into what was once dismissed as junk DNA. Over the past decade, a significant number of lnc...

journal_title：Immunology and cell biology

authors： Yu AD,Wang Z,Morris KV

更新日期：2015-03-01 00:00:00

abstract：:Granzyme B (GrB) plays a well-established intracellular role in cytotoxic lymphocyte (CL)-mediated killing of abnormal cells; however, emerging evidence suggests that it participates in extracellular matrix remodeling and target cell destruction through anoikis. As these processes require the release of GrB from the C...

journal_title：Immunology and cell biology

authors： Prakash MD,Bird CH,Bird PI

更新日期：2009-03-01 00:00:00

abstract：:Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...

journal_title：Immunology and cell biology

authors： Gregory KJ,Morin SM,Kubosiak A,Ser-Dolansky J,Schalet BJ,Jerry DJ,Schneider SS

更新日期：2020-11-01 00:00:00

abstract：:After positive selection, the newly differentiated single-positive (SP) thymocytes undergo negative selection to eliminate autoreactive T cells, functional maturation to acquire immunocompetence and egress capability. To investigate whether the intracellular reduction/oxidation (redox) balance has an important role on...

journal_title：Immunology and cell biology

authors： Jin R,Teng F,Xu X,Yao Y,Zhang S,Sun X,Zhang Y,Ge Q

更新日期：2013-11-01 00:00:00

abstract：:The glycoprotein processing inhibitor castanospermine (CS) and the monosaccharide mannose-6-phosphate (M6P), as well as some sulfated polysaccharides (SPS), have been shown to inhibit inflammation in rat models of experimental autoimmune encephalomyelitis and adjuvant-induced arthritis. Here, the anti-inflammatory eff...

journal_title：Immunology and cell biology

authors： Bartlett MR,Warren HS,Cowden WB,Parish CR

更新日期：1994-10-01 00:00:00

abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

journal_title：Immunology and cell biology

authors： Wagle MV,Parish IA

更新日期：2016-10-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

journal_title：Immunology and cell biology

authors： Xu Y,Hunt NH,Bao S

更新日期：2007-11-01 00:00:00

abstract：:The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary r...

journal_title：Immunology and cell biology

authors： de Jong BG,IJspeert H,Marques L,van der Burg M,van Dongen JJ,Loos BG,van Zelm MC

更新日期：2017-10-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite causative of clinical infections in a wide range of animal hosts. The maturation and activation of splenic conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were studied here in BALB/c mice challenged intraperitoneal with N. caninum tachyzoites. The nu...

journal_title：Immunology and cell biology

authors： Teixeira L,Botelho AS,Mesquita SD,Correia A,Cerca F,Costa R,Sampaio P,Castro AG,Vilanova M

更新日期：2010-01-01 00:00:00

abstract：:Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized the programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, and investigated their influence on helper T (Th) cell responses. Although a...

journal_title：Immunology and cell biology

authors： Tavukcuoglu E,Horzum U,Yilmaz KB,Esendagli G

更新日期：2020-02-01 00:00:00

abstract：:It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The ev...

journal_title：Immunology and cell biology

authors： Anderson RW

更新日期：1996-06-01 00:00:00

abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

journal_title：Immunology and cell biology

authors： Sullivan M

更新日期：2009-07-01 00:00:00

abstract：:Peyer's patches (PP) are important inductive sites for the mucosal immune response. It is well known that lymphocytes that migrate into PP are mainly of T-cell lineage from thymus-derived cells (i.e. alphabetaTCR(high) cells). In this study, we further characterized the properties of PP lymphocytes in mice using a mou...

journal_title：Immunology and cell biology

authors： Takahashi S,Kawamura T,Kanda Y,Taniguchi T,Nishizawa T,Iiai T,Hatakeyama K,Abo T

更新日期：2005-10-01 00:00:00

abstract：:Infection of mice with the flaviviruses West Nile virus (WNV) and Murray Valley encephalitis (MVE) induces cytolytic T-cell responses which are highly cross-reactive on target cells infected with heterologous flaviviruses. Of C57BL/6 mice infected with low doses (10(2)-10(6) PFU) of either virus, 30-40% develop enceph...

journal_title：Immunology and cell biology

authors： Wang Y,Lobigs M,Lee E,Müllbacher A

更新日期：2004-04-01 00:00:00

abstract：:Intravenous (i.v.) immunization of mice with recombinant vaccinia viruses stimulated the highest antibody and cytotoxic T lymphocyte (CTL) responses when i.v., intraperitoneal (i.p.), intranasal (i.n.), footpad (f.p.) and tail scarification (t.s.) routes were compared. Intraperitoneal immunization of mice resulted in ...

journal_title：Immunology and cell biology

authors： Andrew ME,Coupar BE,Boyle DB

更新日期：1989-10-01 00:00:00

abstract：:Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the m...

journal_title：Immunology and cell biology

authors： Miyara M,Sakaguchi S

更新日期：2011-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are abundant small molecules of ≈ 22 nucleotides that reprogram gene expression by targeting mRNA degradation and translation disruption. An emerging concept implicates miRNA coupling with transcription factors in myeloid-based development of dendritic cells, monocytes and granulocytes, as well as f...

journal_title：Immunology and cell biology

authors： El Gazzar M,McCall CE

更新日期：2012-07-01 00:00:00

abstract：:The pathogenesis of autoimmune disease remains an enigma. Here, the condition is analysed from an evolutionary standpoint, and the thesis developed that viruses, in particular retroviruses, are important to our evolution, and that their inappropriate re-expression by repetitive (? ischaemic) cell damage in individuals...

journal_title：Immunology and cell biology

authors： Boyd GW

更新日期：1997-10-01 00:00:00

abstract：:The recognition of T cell receptors (TCR) by purified major histocompatibility complex (MHC) class II-peptide complexes in the absence of costimulatory signals leads to the induction of T cell non-responsiveness or anergy. In a recent study using human T cell clones, it was observed that prolonged incubation of restin...

journal_title：Immunology and cell biology

authors： Arimilli S,Mumm JB,Nag B

更新日期：1996-02-01 00:00:00

abstract：:Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosphatase 1 (SHP-1, Pt...

journal_title：Immunology and cell biology

authors： Watson HA,Dolton G,Ohme J,Ladell K,Vigar M,Wehenkel S,Hindley J,Mohammed RN,Miners K,Luckwell RA,Price DA,Matthews RJ,Ager A

更新日期：2016-09-01 00:00:00

abstract：:Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 si...

journal_title：Immunology and cell biology

authors： Yang K,Zhang Y,Xu C,Li X,Li D

更新日期：2016-03-01 00:00:00

abstract：:The iscom is a delivery system, designed for both parenteral and mucosal modes of administration, for both antigens and adjuvants, components which are interchangeable. By the parenteral route a prominent systemic Th1 type of response is evoked, but the mucosal immunoglobulin A (IgA) response was insignificant. Intran...

journal_title：Immunology and cell biology

authors： Morein F,Bengtsson KL

更新日期：1998-08-01 00:00:00

abstract：:Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein-based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through...

journal_title：Immunology and cell biology

authors： Stewart TJ,Fernando GJ,Frazer IH,Leggatt GR

更新日期：2004-10-01 00:00:00

abstract：:Vaccination has been important in controlling a wide variety of viral and bacterial infections of man and animals. Vaccines to herpesvirus infection of cattle are no exception. The present review describes the different types of conventional vaccines that have been used to date and furthermore describes the novel appr...

journal_title：Immunology and cell biology

authors： van Drunen Littel-van den Hurk S,Tikoo SK,Liang X,Babiuk LA

更新日期：1993-10-01 00:00:00

abstract：:Endothelial cell (EC)-neutrophil (PMN) interactions are crucial in the resolution of bacterial infections. Prokaryotic RNA (pRNA) has been reported as a pathogen-associated molecular pattern that is released from bacteria upon death and is able to activate PMN. In this work, we studied the effects of pRNA on EC and in...

journal_title：Immunology and cell biology

authors： Castillo LA,Birnberg Weiss F,Rodriguez-Rodrigues N,Pittaluga JR,Martire-Greco D,Milillo MA,Grinstein SF,Camelli MR,Mena Aybar AJ,Landoni VI,Fernández GC

更新日期：2019-10-01 00:00:00

abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

journal_title：Immunology and cell biology

authors： Ohki K,Amano F,Yamamoto S,Kohashi O

更新日期：1999-04-01 00:00:00

abstract：:Asthma is a common and complex inflammatory disease of the airways that remains incurable. Current forms of therapy are long term and may exhibit associated side-effect problems. Major participants in the development of an asthma phenotype include the triggering stimuli such as the allergens themselves, cells such as ...

journal_title：Immunology and cell biology

authors： Ramshaw HS,Woodcock JM,Bagley CJ,McClure BJ,Hercus TR,Lopez AF

更新日期：2001-04-01 00:00:00