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TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO.

Abstract：

:FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that expression of CD39 and CD45RO distinguishes three sub-populations within human CD4(+)CD25(hi) T cells. Initial phenotypic and functional analysis demonstrated that CD4(+)CD25(hi)CD39(+)CD45RO(+) cells had properties consistent with effector Treg, CD4(+)CD25(hi)CD39(-)CD45RO(-) cells were naïve Treg and CD4(+)CD25(hi)CD39(-)CD45RO(+) cells were predominantly non-Treg with effector T-cell function. Differences in these two newly identified Treg subsets were corroborated by studies of gene expression and TCR analysis. To apply this approach, we studied these two newly identified Treg subsets in ankylosing spondylitis, and showed impairment in both effector and naïve Treg. This work highlights the importance of discriminating Treg subsets to enable proper comparisons of immune regulatory capacity in healthy individuals and those with inflammatory disease.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Ye L,Goodall JC,Zhang L,Putintseva EV,Lam B,Jiang L,Liu W,Yin J,Lin L,Li T,Wu X,Yeo G,Shugay M,Chudakov DM,Gaston H,Xu H

doi

10.1038/icb.2015.90

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

293-305

issue

3

eissn

0818-9641

issn

1440-1711

pii

icb201590

journal_volume

94

pub_type

杂志文章

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