Abstract:
:Parturition is associated with myometrial and cervical inflammation. The causes and consequences of this inflammatory response are not clear. Mast cells (MCs) are important inducers of allergic and non-allergic inflammation, and their secreted products can induce myometrial contractions. Thus, mast cell activation has been hypothesized to have a role in initiating labor and/or driving labor-associated inflammation. We report that small numbers of MCs expressing chymase and tryptase are present in the myometrium and cervix of pregnant women. Labor did not lead to any change in mast cell abundance in these tissues, but was associated with reduced expression of the mast-cell regulator FcεR1A, indicative of a change in mast cell properties. This coincided with contraction-dependent myocyte production of interleukin-10 (IL-10), a known suppressor of FcεR1A expression. MCs were also found in the uterine horn and cervical region of pregnant C57BL/6 mice, increasing in number in the cervix, but not the myometrium, with labor. As expected, these cells were absent from mast-cell-deficient Kit(W-sh) mice. Nonetheless, pregnant Kit(W-sh) mice showed no defects in the timing of labor induction or in the upregulation of leukocyte markers during labor. Thus, MCs are present in the uterus and cervix of humans and mice, and our mouse studies suggest that they do not have a vital role in the induction of labor, or in the promotion of labor-associated inflammation.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Menzies FM,Higgins CA,Shepherd MC,Nibbs RJ,Nelson SMdoi
10.1038/icb.2011.40subject
Has Abstractpub_date
2012-03-01 00:00:00pages
321-9issue
3eissn
0818-9641issn
1440-1711pii
icb201140journal_volume
90pub_type
杂志文章abstract::Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12362
更新日期:2020-09-01 00:00:00
abstract::The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1990.3
更新日期:1990-02-01 00:00:00
abstract::Retinoic acid (RA) in the steady state enhances induction of Foxp3(+) regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby maintaining tolerance, but can in inflammatory conditions promote effector Th1 and Th17 cells that mediate inflammation. IL-17-producing γδ T cells have recently b...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2016.39
更新日期:2016-09-01 00:00:00
abstract::Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. These proteins are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. Because differential splicing pro...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1711.2003.01159.x
更新日期:2003-06-01 00:00:00
abstract::Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2014.3
更新日期:2014-04-01 00:00:00
abstract::Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1997.33
更新日期:1997-04-01 00:00:00
abstract::Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2009.92
更新日期:2010-02-01 00:00:00
abstract::There is an urgent need for new, powerful adjuvants suitable for use with sub-unit and peptide vaccines in humans. We have measured the humoral immune response in BALB/c mice to vaccine formulations using recombinant HBsAg antigens, and gamma inulin and alum adjuvants. Using Merck, Sharpe & Dohme (MSD) HBsAg at 10 mic...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1990.15
更新日期:1990-04-01 00:00:00
abstract::Plasma cells play a pivotal role in the immune system and are responsible for the synthesis and release of immunoglobulins. Numerous in vitro culture experiments on the yolk sac demonstrated the generation of mature cells of the myeloid and lymphoid lineages under appropriate culture conditions. However, there are no ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2003.t01-1-01178.x
更新日期:2003-10-01 00:00:00
abstract::T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2014.113
更新日期:2015-05-01 00:00:00
abstract::In their recent publication, Kuczma and colleagues have provided evidence that advances the relationship between naive T cells, T cell anergy and T regulatory cells. Their findings strengthen the understanding of how these T cell subsets function in relation to self and microbiota-derived epitopes to promote and maint...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12424
更新日期:2020-12-04 00:00:00
abstract::Interleukin (IL)-15 overexpression in eosinophilic gastrointestinal disorders is reported, but IL-15's role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte-overexpressed IL-15 transgenic mice using Fabpi promoter. The Fabpi-IL-15 (iIL-15) transgenic mice showed induced ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.1036
更新日期:2018-03-01 00:00:00
abstract::Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1711.2006.01420.x
更新日期:2006-04-01 00:00:00
abstract::Mice infected with Sarcocystis muris showed a significant reduction in plaque-forming cells (PFC) and delayed-type hypersensitivity (DHS) responses to an unrelated protein antigen, bovine gamma-globulin, when compared with uninfected controls. This immunosuppression was observed only when infection preceded immunizati...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1988.26
更新日期:1988-01-01 00:00:00
abstract::Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype ...
journal_title:Immunology and cell biology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/icb.2013.84
更新日期:2014-02-01 00:00:00
abstract::Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT). In this report, we track inhaled antigen in normal mice for 7 days and find that while it is cleared from the airways, inhaled antigen persists in peripheral lung tissue and the draining lymph nodes (DLNs). The persisten...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2010.18
更新日期:2010-08-01 00:00:00
abstract::Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12381
更新日期:2020-11-01 00:00:00
abstract::Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/j.1440-1711.2004.01303.x
更新日期:2005-02-01 00:00:00
abstract::There is a need for non-living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Here we describe our experience with lipophilic immune-stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A. When given orally, ISCOMs containin...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1711.1998.00749.x
更新日期:1998-06-01 00:00:00
abstract::Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in t...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.1996.77
更新日期:1996-10-01 00:00:00
abstract::A clone of cells secreting an antibody to an epidermal antigen was generated from a patient with a blistering skin lesion. Although produced by fusion of human lymphocytes to a HAT-sensitive myeloma, this clone of cells did not have characteristics of a hybridoma. A true hybridoma was produced by fusion of this clone ...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1988.30
更新日期:1988-01-01 00:00:00
abstract::Infections caused by group A streptococcus (GAS) represent a public health problem in both developing and developed countries. The current available methods of prevention are either inadequate or ineffective, which is highlighted by the resurgence in invasive GAS infections over the past two decades. The management of...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.2009.29
更新日期:2009-07-01 00:00:00
abstract::Neospora caninum is a coccidian parasite causative of clinical infections in a wide range of animal hosts. The maturation and activation of splenic conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were studied here in BALB/c mice challenged intraperitoneal with N. caninum tachyzoites. The nu...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2009.65
更新日期:2010-01-01 00:00:00
abstract::Mucosal mast cells (MMCs) have an important role in allergic inflammation, and effective antagonists are required for their regulation. To discover a possible mechanism of controlling the activation of MMCs, we investigated the expression and function of syntaxin4, one of the soluble membrane N-ethylmaleimide-sensitiv...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2011.41
更新日期:2012-03-01 00:00:00
abstract::The identification of the genes that make up rearranged immunoglobulin genes is critical to many studies. For example, the enumeration of mutations in immunoglobulin genes is important for the prognosis of chronic lymphocytic leukemia, and this requires the accurate identification of the germline genes from which a pa...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/sj.icb.7100144
更新日期:2008-02-01 00:00:00
abstract::Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1046/j.1440-1711.2002.01094.x
更新日期:2002-08-01 00:00:00
abstract::Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1991.3
更新日期:1991-02-01 00:00:00
abstract::Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentatio...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1038/icb.1996.85
更新日期:1996-12-01 00:00:00
abstract::The 120-kDa protein product of the c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic protein that is especially abundant in the thymus, indicating an important role for Cbl in thymic signalling. c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple...
journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1711.1998.00768.x
更新日期:1998-10-01 00:00:00
abstract::Sustained-release vaccine delivery systems may enhance the immunogenicity of subunit vaccines and reduce the need for multiple vaccinations. The aim of this study was to develop a thermoresponsive hydrogel using poloxamer 407-chitosan (CP) grafted copolymer as a delivery system for single-shot sustained-release vaccin...
journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1111/imcb.12031
更新日期:2018-07-01 00:00:00