当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals.

Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals.

Abstract：

:Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype predict subclinical atherosclerosis in virologically suppressed HIV-positive individuals with low cardiovascular risk. We enroled 51 virologically suppressed HIV-positive individuals not receiving protease inhibitors or statins and 49 age-matched uninfected controls in this study. Carotid artery intima-media thickness (cIMT) was used as a surrogate marker for CVD, and traditional risk factors, including Framingham risk scores, were recorded. Markers of monocyte activation (CD14, CD16, CCR2, CX3CR1, CD38, HLA-DR and CD11b) were measured in whole-blood samples by flow cytometry. Associations were assessed using univariate and multivariate median regressions. Median cIMT was similar between HIV-positive and HIV-negative participants (P=0.3), although HIV-positive patients had significantly higher Framingham risk score (P=0.009) and systemic inflammation. Expression of two monocyte markers, CD11b and CX3CR1, independently predicted carotid artery thickness in HIV-positive individuals after controlling for Framingham risk score (P=0.025 and 0.015, respectively). These markers were not predictive of carotid artery thickening in controls. Our study indicates that monocyte surface markers may serve as novel predictors of CVD in HIV-positive individuals and is consistent with an important role for monocyte activation in the progression of HIV-related cardiovascular pathology.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Westhorpe CL,Maisa A,Spelman T,Hoy JF,Dewar EM,Karapanagiotidis S,Hearps AC,Cheng WJ,Trevillyan J,Lewin SR,Sviridov D,Elliott JH,Jaworowski A,Dart AM,Crowe SM

doi

10.1038/icb.2013.84

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

133-8

issue

2

eissn

0818-9641

issn

1440-1711

pii

icb201384

journal_volume

92

pub_type

临床试验,杂志文章,多中心研究

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens.

    abstract：:Antibodies can have a protective but non-essential role in natural chlamydial infections dependent on antigen specificity and antibody isotype. IgG is the dominant antibody in both male and female reproductive tract mucosal secretions, and is bi-directionally trafficked across epithelia by the neonatal Fc receptor (Fc...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2013.110

    authors： Armitage CW,O'Meara CP,Harvie MC,Timms P,Blumberg RS,Beagley KW

    更新日期：2014-05-01 00:00:00

  • Lymphocyte migration between mutually tolerant parabiotic rats.

    abstract：:Lymphocytes exchanged rapidly and extensively between mutually tolerant, allogeneic rats following surgical parabiosis. Tolerated allogeneic cells persisted for an extended period in parabiotic partners after separation. A rapid exchange of cells was also observed between parabiosed syngeneic pairs of normal and allog...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1987.29

    authors： McCullagh P

    更新日期：1987-06-01 00:00:00

  • Induction of interleukin-10 expression through Fcalpha receptor in human monocytes and monocyte-derived dendritic cells: role of p38 MAPKinase.

    abstract：:As previously reported by others for immunoglobulin (Ig)G, we observed that IgA can induce interleukin (IL)-10 expression in human monocytes. In this study, we explored the molecular mechanisms of IL-10 induction by IgA in monocytes and monocyte-derived dendritic cells (MD-DCs). Monomeric IgA induced IL-10 production ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2009.120

    authors： Pilette C,Detry B,Guisset A,Gabriels J,Sibille Y

    更新日期：2010-05-01 00:00:00

  • New friendships and old feuds: relationships between innate lymphoid cells and microbial communities.

    abstract：:Mammalian barrier surfaces, including the skin, lung and intestine, are constantly exposed to environmental stimuli, including beneficial and pathogenic microbes, dietary substances and non-organic materials. At these anatomical sites it is essential to maintain barrier integrity to promote tissue homeostasis and prev...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2013.2

    authors： Philip NH,Artis D

    更新日期：2013-03-01 00:00:00

  • Tumour necrosis factor-α stimulates human neutrophils to release preformed activin A.

    abstract：:Activin A, a member of the transforming growth factor-β superfamily, is a critical early mediator of acute inflammation. Activin A release coincides with the release of tumour necrosis factor-α (TNF-α) in models of lipopolysaccharide (LPS)-induced inflammation. The source of circulating activin A during acute inflamma...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2011.12

    authors： Chen Y,Wu H,Winnall WR,Loveland KL,Makanji Y,Phillips DJ,Smith JA,Hedger MP

    更新日期：2011-11-01 00:00:00

  • Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns.

    abstract：:Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the m...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2010.137

    authors： Miyara M,Sakaguchi S

    更新日期：2011-03-01 00:00:00

  • Lung homing T-cell generation is dependent on strength and timing of antigen delivery to lymph nodes.

    abstract：:Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT). In this report, we track inhaled antigen in normal mice for 7 days and find that while it is cleared from the airways, inhaled antigen persists in peripheral lung tissue and the draining lymph nodes (DLNs). The persisten...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.18

    authors： Wikstrom ME,Batanero E,Judd SR,Wiqvist K,Holt PG,Stumbles PA

    更新日期：2010-08-01 00:00:00

  • GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

    abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) and urokinase-type plasminogen activator (uPA) can contribute to the progression of chronic inflammatory diseases with possible involvement of macrophages. In this study, we investigated the role of both GM-CSF and uPA in Porphyromonas gingivalis-induced experi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.25

    authors： Lam RS,O'Brien-Simpson NM,Hamilton JA,Lenzo JC,Holden JA,Brammar GC,Orth RK,Tan Y,Walsh KA,Fleetwood AJ,Reynolds EC

    更新日期：2015-09-01 00:00:00

  • Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.

    abstract：:Brucellosis remains a significant zoonotic threat worldwide. Humans and animals acquire infection via their oropharynx and upper respiratory tract following oral or aerosol exposure. After mucosal infection, brucellosis develops into a systemic disease. Mucosal vaccination could offer a viable alternative to conventio...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.5

    authors： Clapp B,Yang X,Thornburg T,Walters N,Pascual DW

    更新日期：2016-05-01 00:00:00

  • Genetic susceptibility to mycobacterial disease in humans.

    abstract：:Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-c...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1711.2006.01420.x

    authors： Fernando SL,Britton WJ

    更新日期：2006-04-01 00:00:00

  • Molecular cloning and characterization of a ruminant interleukin-6 cDNA.

    abstract：:By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.39

    authors： Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

    更新日期：1993-08-01 00:00:00

  • Role for plasmacytoid dendritic cells in anti-HIV innate immunity.

    abstract：:The role of plasmacytoid dendritic cells (pDC) in anti-HIV immunity is mostly represented by the production of type I IFN in response to HIV infection in vitro and in vivo. This production is decreased in HIV-1 infected patients at the time of primary infection and during chronic disease in association with progressio...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1711.2005.01394.x

    authors： Müller-Trutwin M,Hosmalin A

    更新日期：2005-10-01 00:00:00

  • Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile.

    abstract：:During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.22

    authors： Balboa L,Romero MM,Yokobori N,Schierloh P,Geffner L,Basile JI,Musella RM,Abbate E,de la Barrera S,Sasiain MC,Alemán M

    更新日期：2010-10-01 00:00:00

  • Immune stimulating complexes as mucosal vaccines.

    abstract：:There is a need for non-living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Here we describe our experience with lipophilic immune-stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A. When given orally, ISCOMs containin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.1998.00749.x

    authors： Smith RE,Donachie AM,Mowat AM

    更新日期：1998-06-01 00:00:00

  • Bovine herpesvirus-1 vaccines.

    abstract：:Vaccination has been important in controlling a wide variety of viral and bacterial infections of man and animals. Vaccines to herpesvirus infection of cattle are no exception. The present review describes the different types of conventional vaccines that have been used to date and furthermore describes the novel appr...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1993.47

    authors： van Drunen Littel-van den Hurk S,Tikoo SK,Liang X,Babiuk LA

    更新日期：1993-10-01 00:00:00

  • Anti-tumour activity of aminopterin-monoclonal antibody conjugates; in vitro and in vivo comparison with methotrexate-monoclonal antibody conjugates.

    abstract：:Two related folate antagonists aminopterin (AMN) and methotrexate (MTX) were used to produce drug-antibody conjugates and their tumouricidal effects compared in vitro and in vivo. Active ester derivatives were produced with the use of N-hydroxysuccinimide (NHS) and covalently coupled to monoclonal antibodies (MoAb) re...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1987.57

    authors： Kanellos J,Pietersz GA,Cunningham Z,McKenzie IF

    更新日期：1987-12-01 00:00:00

  • Effects of IL-10- and FasL-overexpressing dendritic cells on liver transplantation tolerance in a heterotopic liver transplantation rat model.

    abstract：:Acute rejection is the major determinant for the long-term survival of donor liver after liver transplantation (LT). The aim of this study was to examine the therapeutic potential of interleukin (IL)-10-FasL-overexpressing immature dendritic cells (imDCs) to induce local immunosuppression in liver grafts. imDCs derive...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.12252

    authors： Chen L,Zhang L,Zhu Z,He W,Gao L,Zhang W,Liu J,Huang A

    更新日期：2019-09-01 00:00:00

  • Natural killer and natural cytotoxic cells are present at the maternal-fetal interface during murine pregnancy.

    abstract：:NK cell activity has been detected in the early murine decidua, and hypothesized to be mediated by granulated metrial gland (GMG) cells. The possibility that natural cytotoxic (NC) cells are also present in the decidua has not been investigated. In this study mAb to NK cells (anti-NK-1.1) and NC cells (anti-NC-1.1) we...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1994.23

    authors： Clarke GR,Roberts TK,Smart YC

    更新日期：1994-04-01 00:00:00

  • Early activation of mucosal mast cells during the primary immune response in a rodent model of neonatal asthma.

    abstract：:During an allergic inflammatory response in the airway, if a failure of the epithelial cell barrier occurs before the systemic immune response is triggered by allergens, more allergens can invade. Using a rat model of asthma, we previously found that mucosal mast cells, which localise to the epithelial layer of the ai...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.90

    authors： Liu S,Shudou M,Maeyama K

    更新日期：2011-02-01 00:00:00

  • Peritoneal cavity CD5 (Bla) B cells: cytokine induced IgA secretion and homing to intestinal lamina propria in SCID mice.

    abstract：:The mouse peritoneal cavity contains a unique population of B cells (Bla) with a high IgM/low IgD ratio, CD5+ (Ly1), MAC-1 + phenotype. These cells arise early in ontogeny, utilize a limited repertoire of immunoglobulin V genes, produce polyreactive IgM antibodies and have been implicated as the source of many auto-re...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1995.66

    authors： Beagley KW,Murray AM,McGhee JR,Eldridge JH

    更新日期：1995-10-01 00:00:00

  • Development of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B core antigen to stimulate a strong Th1 response against hepatitis B surface antigen.

    abstract：:There are estimated to be 350 million chronic carriers of hepatitis B infection worldwide. Patients with chronic hepatitis B are at risk of liver cirrhosis with associated mortality because of hepatocellular carcinoma and other complications. An important goal, therefore, is the development of an effective therapeutic...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.0818-9641.2004.01278.x

    authors： Aguilar JC,Lobaina Y,Muzio V,García D,Pentón E,Iglesias E,Pichardo D,Urquiza D,Rodríguez D,Silva D,Petrovsky N,Guillén G

    更新日期：2004-10-01 00:00:00

  • DNA vaccines for parasitic infections.

    abstract：:There has been a tremendous explosion in the area of DNA vaccine research over the last 4 years, particularly in relation to antiviral vaccines. This report discusses the development and application of this new technology with regard to parasitic infections. Progress has been made towards the development of a vaccine ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1997.58

    authors： Kalinna BH

    更新日期：1997-08-01 00:00:00

  • Identification of mature plasma cells in early rat yolk sac. A possible origin from the endodermal cell layer: immunohistochemistry and immunoelectron microscopic study.

    abstract：:Plasma cells play a pivotal role in the immune system and are responsible for the synthesis and release of immunoglobulins. Numerous in vitro culture experiments on the yolk sac demonstrated the generation of mature cells of the myeloid and lymphoid lineages under appropriate culture conditions. However, there are no ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2003.t01-1-01178.x

    authors： El-Nefiawy N,Abdel-Hakim K,Kanayama N,Suganuma N,Terao T

    更新日期：2003-10-01 00:00:00

  • Immune response to orally consumed antigens and probiotic bacteria.

    abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2000.00883.x

    authors： Chin J,Turner B,Barchia I,Mullbacher A

    更新日期：2000-02-01 00:00:00

  • In silico simulations suggest that Th-cell development is regulated by both selective and instructive mechanisms.

    abstract：:Th-cell differentiation is highly influenced by the local cytokine environment. Although cytokines such as IL-12 and IL-4 are known to polarize the Th-cell response towards Th1 or Th2, respectively, it is not known whether these cytokines instruct the developmental fate of uncommitted Th cells or select cells that hav...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2006.01425.x

    authors： Jansson A,Fagerlind M,Karlsson D,Nilsson P,Cooley M

    更新日期：2006-04-01 00:00:00

  • Phagocytosis and transcytosis by the follicle-associated epithelium of the ileal Peyer's patch in calves.

    abstract：:Latex beads, 250 and 610 nm in diameter, and parapox virus isolated from ecthyma in sheep, were injected into intestinal loops containing either jejunal or ileal Peyer's patches (PP) of 3-4 week old calves. Uptake of latex and parapox virus was restricted to the ileal PP, 30-60 min after injection. The latex beads see...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1988.35

    authors： Landsverk T

    更新日期：1988-08-01 00:00:00

  • Multiple levels of post-transcriptional regulation of collagenase (matrix metalloproteinase 1) in an epithelial cell line.

    abstract：:Multiple levels of regulation of collagenase (matrix metalloproteinase 1; MMP-1), have been demonstrated in a clonal rat epithelial cell line (A5P/B10). Secreted enzyme could not be demonstrated in culture medium from A5P/B10 cells but, using antibodies specific for collagenase, the enzyme was detected within the cyto...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.4

    authors： Whitelock JM,Paine ML,Gibbins JR,Kefford RF,O'Grady RL

    更新日期：1993-02-01 00:00:00

  • Dual mechanisms of inhibition of the immune response by enterocytes isolated from the rat small intestine.

    abstract：:Antigen presentation by enterocytes isolated from the rat small bowel was studied by using T cell proliferation, and immunoregulatory function in an antigen-driven culture system, as indicator systems. Lymph node T cells obtained from rats immunized with ovalbumin (OA) failed to divide when cultured for 4 days in the ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1990.52

    authors： Pang G,Clancy R,Saunders H

    更新日期：1990-12-01 00:00:00

  • Production of a recombinant form of early pregnancy factor that can prolong allogeneic skin graft survival time in rats.

    abstract：:Early pregnancy factor (EPF), an extracellular chaperonin 10 homologue, has immunosuppressive and growth factor properties. In order to carry out more extensive studies on the in vivo characteristics of EPF, a recombinant form of the molecule has been prepared. Recombinant human EPF (rEPF) was expressed in Escherichia...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2000.00951.x

    authors： Morton H,McKay DA,Murphy RM,Somodevilla-Torres MJ,Swanson CE,Cassady AI,Summers KM,Cavanagh AC

    更新日期：2000-12-01 00:00:00

  • Excretory-secretory antigens from adult Nematospiroides dubius.

    abstract：:Adult Nematospiroides dubius excretory-secretory (ES) products were collected from worms cultured in vitro, radiolabelled and separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE). The components were characterized and assessed for molecular weight (MW) after autoradiography and gel staining, for a...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1989.16

    authors： Monroy FG,Adams JH,East IJ,Dobson C

    更新日期：1989-04-01 00:00:00