Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens.

abstract：:Activin A, a member of the transforming growth factor-β superfamily, is a critical early mediator of acute inflammation. Activin A release coincides with the release of tumour necrosis factor-α (TNF-α) in models of lipopolysaccharide (LPS)-induced inflammation. The source of circulating activin A during acute inflamma...

journal_title：Immunology and cell biology

authors： Chen Y,Wu H,Winnall WR,Loveland KL,Makanji Y,Phillips DJ,Smith JA,Hedger MP

更新日期：2011-11-01 00:00:00

abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...

journal_title：Immunology and cell biology

authors： Chin J,Turner B,Barchia I,Mullbacher A

更新日期：2000-02-01 00:00:00

abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

journal_title：Immunology and cell biology

authors： Chazaud B

更新日期：2016-02-01 00:00:00

abstract：:Mucosal addressin cell adhesion molecule (MAdCAM-1) is a key player in mediating the infiltration of leucocytes into chronically inflamed tissues. Five anti-MAdCAM-1 monoclonal antibodies (mAb), designated 17F5, 201F7, 314G8, 377D10 and 355G8, were generated by fusion of P3 x 63Ag8.653 myeloma cells with spleen cells ...

journal_title：Immunology and cell biology

authors： Leung E,Lehnert KB,Kanwar JR,Yang Y,Mon Y,McNeil HP,Krissansen GW

更新日期：2004-08-01 00:00:00

abstract：:Parturition is associated with myometrial and cervical inflammation. The causes and consequences of this inflammatory response are not clear. Mast cells (MCs) are important inducers of allergic and non-allergic inflammation, and their secreted products can induce myometrial contractions. Thus, mast cell activation has...

journal_title：Immunology and cell biology

authors： Menzies FM,Higgins CA,Shepherd MC,Nibbs RJ,Nelson SM

更新日期：2012-03-01 00:00:00

abstract：:The central pathogenic feature of AIDS is the dramatic loss of CD4+ lymphocytes. Despite more than a decade of intense research, the exact mechanism by which HIV causes this is still not understood. A major model for T cell depletion, proposed originally by Ameison and Capron in a report published in 1991, is that HIV...

journal_title：Immunology and cell biology

authors： Jaworowski A,Crowe SM

更新日期：1999-02-01 00:00:00

abstract：:Cancer immunosurveillance representing, till recently, the explanatory framework relating cancer and the immune system, does not convincingly explain tumor escape. At the beginning of the decade, a new theory emerged, namely the immunoediting theory, and it comprehensively defines the role of the immune system in carc...

journal_title：Immunology and cell biology

authors： Germenis AE,Karanikas V

更新日期：2007-01-01 00:00:00

abstract：:Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRR...

journal_title：Immunology and cell biology

authors： Yu L,Liu G,Yang C,Song X,Wang H

更新日期：2016-10-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in t...

journal_title：Immunology and cell biology

authors： Körner H,Sedgwick JD

更新日期：1996-10-01 00:00:00

abstract：:Technetium-99 m (99mTc)-labelled conjugates of an anti-fibrin monoclonal antibody, DD-3B6/22, have been assessed for their detection of vascular thrombi in a rabbit model. DD-3B6/22 binds to a D-dimer epitope present on cross-linked fibrin but absent from the fibrin monomer or fibrinogen. Injection of a 99mTc-labelled...

journal_title：Immunology and cell biology

authors： Lee FT,Milner LJ,Boniface GR,Bautovich GJ,Weedon AR,Bundesen PG,Rylatt DB,Walker KZ

更新日期：1992-06-01 00:00:00

abstract：:Acute rejection is the major determinant for the long-term survival of donor liver after liver transplantation (LT). The aim of this study was to examine the therapeutic potential of interleukin (IL)-10-FasL-overexpressing immature dendritic cells (imDCs) to induce local immunosuppression in liver grafts. imDCs derive...

journal_title：Immunology and cell biology

authors： Chen L,Zhang L,Zhu Z,He W,Gao L,Zhang W,Liu J,Huang A

更新日期：2019-09-01 00:00:00

abstract：:Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...

journal_title：Immunology and cell biology

authors： Ruszala-Mallon V,Silva J,Lumanglas AL,Durr FE,Wang BS

更新日期：1991-02-01 00:00:00

abstract：:Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as w...

journal_title：Immunology and cell biology

authors： Patras KA,Coady A,Olson J,Ali SR,RamachandraRao SP,Kumar S,Varki A,Nizet V

更新日期：2017-11-01 00:00:00

abstract：:Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...

journal_title：Immunology and cell biology

authors： Marsland BJ,Camberis M,Le Gros G

更新日期：2005-02-01 00:00:00

abstract：:The possible role and influence of tumour necrosis factor-alpha (TNF-alpha) in the human mixed lymphocyte culture (MLC) reaction was investigated. Polyclonal rabbit sera to recombinant human-TNF-alpha (rhTNF-alpha) consistently inhibited the MLC, and this could be reversed by simultaneous addition of rhTNF-alpha to th...

journal_title：Immunology and cell biology

authors： Matthews SJ,Sullivan JS

更新日期：1992-04-01 00:00:00

abstract：:A murine monoclonal antibody has been used to characterise a 45,000 Da antigen that is associated with the surface membrane of merozoites of the human malaria parasite Plasmodium falciparum. The antigen is a glycoprotein and incorporates myristic acid. ...

journal_title：Immunology and cell biology

authors： Ramasamy R

更新日期：1987-10-01 00:00:00

abstract：:Interleukin (IL)-9-producing CD4(+) T cells are a novel subset of T helper (Th) cells that develops independently of the Th1, Th2, Th17 and regulatory T-cell lineages. Similar to the murine model, transforming growth factor (TGF)-beta and IL-4 directed human naive CD4(+) T cells to produce IL-9. Whereas IL-4 suppresse...

journal_title：Immunology and cell biology

authors： Wong MT,Ye JJ,Alonso MN,Landrigan A,Cheung RK,Engleman E,Utz PJ

更新日期：2010-08-01 00:00:00

abstract：:Antigen presentation by enterocytes isolated from the rat small bowel was studied by using T cell proliferation, and immunoregulatory function in an antigen-driven culture system, as indicator systems. Lymph node T cells obtained from rats immunized with ovalbumin (OA) failed to divide when cultured for 4 days in the ...

journal_title：Immunology and cell biology

authors： Pang G,Clancy R,Saunders H

更新日期：1990-12-01 00:00:00

abstract：:Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing several inhibitors. A novel peroxidase detection system was used and te...

journal_title：Immunology and cell biology

authors： Shuler RL,Owen CS

更新日期：1993-02-01 00:00:00

abstract：:Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosphatase 1 (SHP-1, Pt...

journal_title：Immunology and cell biology

authors： Watson HA,Dolton G,Ohme J,Ladell K,Vigar M,Wehenkel S,Hindley J,Mohammed RN,Miners K,Luckwell RA,Price DA,Matthews RJ,Ager A

更新日期：2016-09-01 00:00:00

abstract：:After positive selection, the newly differentiated single-positive (SP) thymocytes undergo negative selection to eliminate autoreactive T cells, functional maturation to acquire immunocompetence and egress capability. To investigate whether the intracellular reduction/oxidation (redox) balance has an important role on...

journal_title：Immunology and cell biology

authors： Jin R,Teng F,Xu X,Yao Y,Zhang S,Sun X,Zhang Y,Ge Q

更新日期：2013-11-01 00:00:00

abstract：:The iscom is a delivery system, designed for both parenteral and mucosal modes of administration, for both antigens and adjuvants, components which are interchangeable. By the parenteral route a prominent systemic Th1 type of response is evoked, but the mucosal immunoglobulin A (IgA) response was insignificant. Intran...

journal_title：Immunology and cell biology

authors： Morein F,Bengtsson KL

更新日期：1998-08-01 00:00:00

abstract：:The pathogenesis of autoimmune disease remains an enigma. Here, the condition is analysed from an evolutionary standpoint, and the thesis developed that viruses, in particular retroviruses, are important to our evolution, and that their inappropriate re-expression by repetitive (? ischaemic) cell damage in individuals...

journal_title：Immunology and cell biology

authors： Boyd GW

更新日期：1997-10-01 00:00:00

abstract：:CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in the bone marrow (BM). However, the molecular mechanisms of their establishment in the BM and their maintenance remain unclear. We here show that memory CD4 T cells express high levels of CD...

journal_title：Immunology and cell biology

authors： Hanazawa A,Hayashizaki K,Shinoda K,Yagita H,Okumura K,Löhning M,Hara T,Tani-ichi S,Ikuta K,Eckes B,Radbruch A,Tokoyoda K,Nakayama T

更新日期：2013-09-01 00:00:00

abstract：:The cellular effects of biodiesel emissions particulate matter (BDEP) and petroleum diesel emissions particulate matter (PDEP) were compared using a human airway cell line, A549. At concentrations of 25 microg/ml, diesel particulate matter induced the formation of multinucleate cells. In cells treated with a mixture o...

journal_title：Immunology and cell biology

authors： Ackland ML,Zou L,Freestone D,van de Waasenburg S,Michalczyk AA

更新日期：2007-11-01 00:00:00

abstract：:The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cance...

journal_title：Immunology and cell biology

authors： Watkins TS,Miles JJ

更新日期：2020-07-16 00:00:00

abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

journal_title：Immunology and cell biology

authors： Lipoldová M,Holán V

更新日期：1991-12-01 00:00:00

abstract：:The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...

journal_title：Immunology and cell biology

authors： Zanker D,Pang K,Oveissi S,Lu C,Faou P,Nowell C,Mbogo GW,Carotta S,Quillici C,Karupiah G,Hibbs ML,Nutt SL,Neeson P,Puthalakath H,Chen W

更新日期：2018-10-01 00:00:00

abstract：:Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. A phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) mediates cluster formation of the host fungal receptors and enhances the phagocytosis and clearance of pathogenic fungi. Howe...

journal_title：Immunology and cell biology

authors： Zhao G,Hu M,Li C,Lee J,Yuan K,Zhu G,Che C

更新日期：2018-04-01 00:00:00

abstract：:B and T lymphocyte attenuator (BTLA) is an important negative regulator of T-cell activation. T-cell activation involves partitioning of receptors into discrete membrane compartments known as lipid rafts and the formation of an immunological synapse (IS) between the T cell and antigen-presenting cell (APC). Here we sh...

journal_title：Immunology and cell biology

authors： Wu TH,Zhen Y,Zeng C,Yi HF,Zhao Y

更新日期：2007-11-01 00:00:00