Abstract:
:B and T lymphocyte attenuator (BTLA) is an important negative regulator of T-cell activation. T-cell activation involves partitioning of receptors into discrete membrane compartments known as lipid rafts and the formation of an immunological synapse (IS) between the T cell and antigen-presenting cell (APC). Here we show that after T-cell stimulation, BTLA co-clusters with the CD3zeta and is then involved in IS, as determined by a two-photon microscope. BTLA can interact with the phosphorylated form of T-cell receptor (TCR) within the lipid raft, which is associated with the T-cell signaling complex. Coligation of BTLA with the TCR significantly decreased the amount of phosphorylated TCR-related signal accumulation in the lipid raft during T-cell activation. These results suggest that BTLA functions to regulate T-cell signaling by controlling the phosphorylated form of TCRzeta accumulation in the lipid raft.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Wu TH,Zhen Y,Zeng C,Yi HF,Zhao Ydoi
10.1038/sj.icb.7100087subject
Has Abstractpub_date
2007-11-01 00:00:00pages
590-5issue
8eissn
0818-9641issn
1440-1711pii
7100087journal_volume
85pub_type
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