当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > Gonadotropin-releasing hormone agonist influences absolute levels of lymphocyte subsets in vivo in male mice.

Gonadotropin-releasing hormone agonist influences absolute levels of lymphocyte subsets in vivo in male mice.

Abstract：

:Our earlier studies have demonstrated that gonadotropin-releasing hormone (GnRH) agonists suppress immune system function in female mice. No systematic studies regarding the effect of gender on immune system function following GnRH agonist treatment, however, have been reported. This study, therefore, investigated sequential changes in lymphocyte subsets in 3- and 10-week-old male mice following agonist or placebo administration. Changes in immunophenotypic expression of lymphocytes from thymus, bone marrow, spleen, and blood were analysed at periodic intervals. Upon agonist administration, plasma testosterone levels were significantly increased in pre-pubertal mice, but were significantly decreased in post-pubertal males. Absolute thymic weights, thymocytes and T subsets were significantly increased from the third week regardless of gonadal status. Blood lymphocyte subsets showed a decreasing trend after agonist administration in pre-pubertal males, whereas no differences were observed in post-pubertal males. No significant differences were observed in spleen cells after agonist administration. These studies, together with earlier observations in female mice indicate that GnRH agonist effects on the immune system, are independent of steroid hormone levels. In contrast to suppressive effects in females, GnRH agonist induce no change or ultimately enhanced lymphocyte counts in males, indicating differential effects on the immune system between males and females. This may have important implications for the treatment of various diseases.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Rao LV,Cleveland RP,Kimmel RJ,Ataya KM

doi

10.1038/icb.1996.18

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

134-43

issue

2

eissn

0818-9641

issn

1440-1711

journal_volume

74

pub_type

杂志文章

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract.

    abstract：:Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as w...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2017.63

    authors： Patras KA,Coady A,Olson J,Ali SR,RamachandraRao SP,Kumar S,Varki A,Nizet V

    更新日期：2017-11-01 00:00:00

  • B cells: we need them now more than ever.

    abstract：:The humoral immune response, that is, the production of antibodies by B cells, is a critical component of immunity to infection and underlies the protection provided by the majority of successful vaccines. This Special Feature explores some of the latest advances in understanding B cell activation and differentiation,...

    journal_title：Immunology and cell biology

    pub_type： 社论

    doi：10.1111/imcb.12348

    authors： Deenick EK

    更新日期：2020-07-01 00:00:00

  • T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation.

    abstract：:T-cell activation RhoGTPase-activating protein (TAGAP) is a GTPase-activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome-wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, includi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2017.27

    authors： Tamehiro N,Nishida K,Yanobu-Takanashi R,Goto M,Okamura T,Suzuki H

    更新日期：2017-09-01 00:00:00

  • Moving candidate vaccines into development from research: lessons from HIV.

    abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2009.30

    authors： Sullivan M

    更新日期：2009-07-01 00:00:00

  • The human non-lineage antigen CD46 (HuLy-m5) and primate retroviral gp70 molecules share protein-defined antigenic determinants.

    abstract：:The CD46 lymphocyte surface antigen of man (until recently called HuLy-m5), and defined by the E4.3 monoclonal antibody (MoAb), shares cross-reactive antigenic epitopes with the envelope gp70 glycoproteins of gibbon ape leukaemia virus (GaLV) and Mason Pfizer monkey virus (MPMV) primate retroviruses. It is now shown t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1989.42

    authors： Purcell DF,Deacon NJ,McKenzie IF

    更新日期：1989-10-01 00:00:00

  • Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the gamma delta T cell receptor.

    abstract：:This study investigated the role of gamma delta T cells in experimental allergic encephalomyelitis (EAE), a chronic inflammatory disease of the central nervous system (CNS) that resembles multiple sclerosis. The strategy was to assess the effect on EAE of TCR peptide immunization directed against V gamma 6 T cells, sh...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1997.14

    authors： Olive C

    更新日期：1997-02-01 00:00:00

  • Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses.

    abstract：:Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentatio...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1996.85

    authors： Hill AB

    更新日期：1996-12-01 00:00:00

  • Does recycling in germinal centres exist?

    abstract：:A general criterion is formulated to decide if the recycling of B cells exists in germinal centre (GC) reactions. The criterion is independent of the selection and affinity maturation process and based solely on total centroblast population arguments. An experimental test is proposed to verify whether the criterion is...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2002.01052.x

    authors： Meyer-Hermann M

    更新日期：2002-02-01 00:00:00

  • Osteopontin contributes to effective neutrophil recruitment, IL-1β production and apoptosis in Aspergillus fumigatus keratitis.

    abstract：:Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. A phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) mediates cluster formation of the host fungal receptors and enhances the phagocytosis and clearance of pathogenic fungi. Howe...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.12010

    authors： Zhao G,Hu M,Li C,Lee J,Yuan K,Zhu G,Che C

    更新日期：2018-04-01 00:00:00

  • Interleukin-2 activates the gamma-interferon gene in newborn mice.

    abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1991.59

    authors： Lipoldová M,Holán V

    更新日期：1991-12-01 00:00:00

  • Apoptosis may underlie the pathology of zinc-deficient skin.

    abstract：:The trace element zinc is essential for the survival and function of all cells. Zinc deficiency, whether nutritional or genetic, is fatal if left untreated. The effects of zinc deficiency are particularly obvious in the skin, seen as an erythematous rash, scaly plaques, and ulcers. Electron microscopy reveals degenera...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2005.01391.x

    authors： Wilson D,Varigos G,Ackland ML

    更新日期：2006-02-01 00:00:00

  • Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo.

    abstract：:Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macr...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.1035

    authors： Dubey A,Izakelian L,Ayaub EA,Ho L,Stephenson K,Wong S,Kwofie K,Austin RC,Botelho F,Ask K,Richards CD

    更新日期：2018-03-01 00:00:00

  • mTORC1 signaling is crucial for regulatory T cells to suppress macrophage-mediated inflammatory response after acute myocardial infarction.

    abstract：:Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 si...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.88

    authors： Yang K,Zhang Y,Xu C,Li X,Li D

    更新日期：2016-03-01 00:00:00

  • Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA.

    abstract：:Elucidating pathways that regulate cytokine production in the context of autoimmune disease will likely lead to the development of novel therapeutics. Herein, we review data suggesting that microRNAs (miRs) represent one such level of regulatory activity, with particular emphasis on the pathogenesis of rheumatoid arth...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2011.114

    authors： Baxter D,McInnes IB,Kurowska-Stolarska M

    更新日期：2012-03-01 00:00:00

  • The ecology and pathology of Epstein-Barr virus.

    abstract：:Epstein-Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong persistence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: latency in B lymphocytes and replication i...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1995.79

    authors： Schmidt CW,Misko IS

    更新日期：1995-12-01 00:00:00

  • Clearance of Brugia pahangi microfilariae in immunized mice.

    abstract：:Active Brugia pahangi microfilariae (Mf) were injected into naive male BALB/c mice intraperitoneally. Microfilaraemia was studied for 28 days; and Mf circulated in blood in optimum numbers from 3 to 14 days. Anti-Mf response was assessed by the rate of disappearance of Mf from blood as well as their absence from visce...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1988.43

    authors： Rajasekariah GR,Puri PM,Chandrashekar R,Subrahmanyam D

    更新日期：1988-10-01 00:00:00

  • Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response.

    abstract：:Regulatory mechanisms in mucosal secretions and tissues recognize antigens and attenuate pro-inflammatory cytokine responses. Here, we asked whether human beta-defensin 3 (HBD3) serves as an upstream suppressor of cytokine signaling that binds and attenuates pro-inflammatory cytokine responses to recombinant hemagglut...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2008.56

    authors： Pingel LC,Kohlgraf KG,Hansen CJ,Eastman CG,Dietrich DE,Burnell KK,Srikantha RN,Xiao X,Bélanger M,Progulske-Fox A,Cavanaugh JE,Guthmiller JM,Johnson GK,Joly S,Kurago ZB,Dawson DV,Brogden KA

    更新日期：2008-11-01 00:00:00

  • NKT cells are not critical for HSV-1 disease resolution.

    abstract：:NKT cells are a minor subset of T cells that have important roles in controlling immune responses in disease states including cancer, autoimmunity and pathogenic infections. In contrast to conventional T cells, NKT cells express an invariant TCR and respond to glycolipids presented by CD1d. In this study, we sought to...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2005.01396.x

    authors： Cornish AL,Keating R,Kyparissoudis K,Smyth MJ,Carbone FR,Godfrey DI

    更新日期：2006-02-01 00:00:00

  • T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.

    abstract：:CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulat...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2012.71

    authors： Jatzek A,Marie Tejera M,Plisch EH,Fero ML,Suresh M

    更新日期：2013-02-01 00:00:00

  • Immune response to Acanthocheilonema viteae infection in multimammate rats (Mastomys natalensis).

    abstract：:The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1990.3

    authors： Chandrashekar R,Rao UR,Subrahmanyam D

    更新日期：1990-02-01 00:00:00

  • An hypothesis to explain why cell-mediated immunity alone can contain infections by certain intracellular parasites and how immune class regulation of the response against such parasites can be subverted.

    abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1992.44

    authors： Bretscher PA

    更新日期：1992-10-01 00:00:00

  • Multiple levels of post-transcriptional regulation of collagenase (matrix metalloproteinase 1) in an epithelial cell line.

    abstract：:Multiple levels of regulation of collagenase (matrix metalloproteinase 1; MMP-1), have been demonstrated in a clonal rat epithelial cell line (A5P/B10). Secreted enzyme could not be demonstrated in culture medium from A5P/B10 cells but, using antibodies specific for collagenase, the enzyme was detected within the cyto...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.4

    authors： Whitelock JM,Paine ML,Gibbins JR,Kefford RF,O'Grady RL

    更新日期：1993-02-01 00:00:00

  • Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection.

    abstract：:The germinal centre reaction (GCR) is a fundamental component of the immune response to T-dependent antigens, during which the immunoglobulin (Ig) genes of B cells experience somatic hypermutation and selection. A maximum-likelihood method on DNA sequence data from 16 individual germinal centres was used to infer that...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.1998.00753.x

    authors： Radmacher MD,Kelsoe G,Kepler TB

    更新日期：1998-08-01 00:00:00

  • Demystifying the development of dendritic cell subtypes, a little.

    abstract：:The broadest definition of dendritic cells (DCs) is white blood cells that can take up antigen, process it and then present antigen-derived peptides to activate cognate naive T cells. Although this definition is by no means perfect, it is nevertheless now textbook. The source of frustration more recently has focused o...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2008.28

    authors： Naik SH

    更新日期：2008-07-01 00:00:00

  • A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease.

    abstract：:Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2017.61

    authors： Shibata T,Ato M

    更新日期：2017-11-01 00:00:00

  • A role for tumour necrosis factor-alpha in the human mixed lymphocyte culture reaction.

    abstract：:The possible role and influence of tumour necrosis factor-alpha (TNF-alpha) in the human mixed lymphocyte culture (MLC) reaction was investigated. Polyclonal rabbit sera to recombinant human-TNF-alpha (rhTNF-alpha) consistently inhibited the MLC, and this could be reversed by simultaneous addition of rhTNF-alpha to th...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1992.15

    authors： Matthews SJ,Sullivan JS

    更新日期：1992-04-01 00:00:00

  • Suppressive effects of serum on the LPS-induced production of nitric oxide and TNF-alpha by a macrophage-like cell line, WEHI-3, are dependent on the structure of polysaccharide chains in LPS.

    abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.1999.00807.x

    authors： Ohki K,Amano F,Yamamoto S,Kohashi O

    更新日期：1999-04-01 00:00:00

  • Production of interleukin-1 alpha and interleukin-2 by separate, phenotypically different leukaemia and human T cell lymphotropic virus-1-transformed T cell clones.

    abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.56

    authors： Holán V,Minowada J

    更新日期：1993-12-01 00:00:00

  • The role of CD45 and CD45-associated molecules in T cell activation.

    abstract：:CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. On T cells the extracellular domain of CD45 is expressed in several different isoforms, and the particular isoform(s) expressed depends ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1997.68

    authors： Altin JG,Sloan EK

    更新日期：1997-10-01 00:00:00

  • Poloxamer 407-chitosan grafted thermoresponsive hydrogels achieve synchronous and sustained release of antigen and adjuvant from single-shot vaccines.

    abstract：:Sustained-release vaccine delivery systems may enhance the immunogenicity of subunit vaccines and reduce the need for multiple vaccinations. The aim of this study was to develop a thermoresponsive hydrogel using poloxamer 407-chitosan (CP) grafted copolymer as a delivery system for single-shot sustained-release vaccin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.12031

    authors： Bobbala S,Gibson B,Gamble AB,McDowell A,Hook S

    更新日期：2018-07-01 00:00:00